Working Memory Training in Adults With Substance Abuse and Executive Function Deficits.

Depression Clinical Trial

Official title:

Computerized Working Memory Training in Adults With Substance Abuse and Executive Function Deficits: A Randomised Controlled Trial.

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02068261
• Other study ID #: RA02
• Status: Recruiting
• Phase: Phase 2
• First received: February 19, 2014
• Last updated: October 22, 2015
• Start date: January 2014
• Est. completion date: December 2016

Study information

• Verified date: October 2015
• Source: Örebro Läns Landsting
• Contact: Rickard Ahlberg, doctoral student
• Email: rickard.ahlberg[@]orebroll.se
• Is FDA regulated: No
• Health authority: Sweden: The National Board of Health and Welfare
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the effects of a computerized working memory training program on substance abuse, psychosocial functioning, cognitive performance and psychiatric problems in adults with substance abuse and attention problems.

Description:

The primary aim of this study is to examine the effects of 5 weeks of computerized working memory training on substance abuse. Secondary aims are to explore whether effects are mediated by changes in executive functions and/or moderated by personality. Also, effects on measures of psychosocial functioning, depression, anxiety and attention will be explored. Follow-up assessment will be conducted at 6 months post training.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: December 2016
• Est. primary completion date: December 2016
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Treatment seeking adults with substance abuse and executive function deficits.

Exclusion Criteria:

• Acute intoxication or abstinence symptoms of any substance.

• Psychosis.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Antisocial Personality
• Antisocial Personality Disorder
• Anxiety
• Depression
• Dyslexia
• Executive Dysfunction
• Reading Disabilities
• Substance Abuse
• Substance-Related Disorders

Intervention

Behavioral:
• Computerized Cogmed working memory training
Computerized working memory training with Cogmed QM software. The QM software consists of a set of verbal and visual working memory tasks which is trained for 25-40 minutes each session.
• Treatment as usual
Treatment as usual can consist of medication, psychotherapy, counseling, and psychological assessment.

Locations

Country	Name	City	State
Sweden	Psychiatric Research Centre	Örebro

Sponsors (1)

Lead Sponsor	Collaborator
Örebro Läns Landsting

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change from baseline in substance abuse measured with Substance abuse scales in Adult Self Report (ASR; ASEBA).		Baseline and at 25 weeks	No
Secondary	Change from baseline in Adult Self Report (ASR; ASEBA) Attention problems scale.		Baseline and at 25 weeks	No
Secondary	Change from baseline in Adult Self Report (ASR; ASEBA) Internalizing index.		Baseline and at 25 weeks	No
Secondary	Change from baseline in Adult Self Report (ASR; ASEBA) Externalizing index.		Baseline and at 25 weeks	No
Secondary	Change from baseline in Adult Self Report (ASR; ASEBA) Adaptive functioning scales.		Baseline and at 25 weeks	No
Secondary	Change from baseline in Executive functioning measured with Behavior Rating Inventory of Executive Function-Adult (BRIEF-A).		Baseline and at 25 weeks	No
Secondary	Change from baseline in verbal working memory measured with performance on Digit span.		Baseline and at 25 weeks	No
Secondary	Change from baseline in visual working memory measured with performance on Span board.		Baseline and at 25 weeks	No
Secondary	Change from baseline in focused attention measured with performance on Conners Continuous Performance Test-II (CCPT-II).		Baseline and at 25 weeks	No
Secondary	Change from baseline in vigilance measured with performance on Conners Continuous Performance Test-II (CCPT-II).		Baseline and at 25 weeks	No
Secondary	Change from baseline in reading speed measured with performance on Reading speed in Diagnostic Reading and Writing Test (DLS; Swedish version).		Baseline and at 25 weeks	No