Mothers With a History of Depression and Their 10-14 Year Old Daughters

Depression Clinical Trial

Official title:

The Neural Correlates of Mood and Cognitive Bias in a Population at Risk for Depression: Maternal Cognitive and Emotional Functioning

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01129752
• Other study ID #: SU-03172010-5264
• Secondary ID: 13058
• Status: Completed
• Phase: N/A
• First received: May 21, 2010
• Last updated: June 21, 2011
• Start date: February 2004
• Est. completion date: April 2011

Study information

• Verified date: June 2011
• Source: Stanford University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted cross-generationally. The investigators are conducting an integrative assessment of emotion regulation and stress reactivity in a group of mothers with and without a history of depression and their daughters.

Description:

The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted cross-generationally. We are conducting an integrative assessment of emotion regulation and stress reactivity in a group of mothers with and without a history of depression and their daughters. We use a range of methodologies to evaluate these processes, including self-report measures, information-processing performance, HPA-axis functioning and reactivity, and neural responses to emotional stimuli following exposure to stressful experiences.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 240
• Est. completion date: April 2011
• Est. primary completion date: April 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 9 Years to 15 Years

Eligibility

Inclusion Criteria:

• Eligible mothers must read and speak English fluently and have a child between the ages of 9 and 15 years old.

• Mothers must either have no history of psychopathology or have a history of depression during their child's lifetime.

Exclusion Criteria:

• Eligible mothers cannot:

• currently be in treatment for drug or alcohol abuse

• have significant symptomatology related to psychopathology outside of depression

• have a medical history of neurological injury or impairment.

• Mothers who meet the requirements for inclusion in the control group must not have a history of any Axis I disorder.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Depression
• Depressive Disorder
• Depressive Disorder, Major

Intervention

Other:
• No intervention
there is no intervention for this study

Locations

Country	Name	City	State
United States	Stanford University Department of Psychology	Stanford	California
United States	Stanford University School of Medicine	Stanford	California

Sponsors (2)

Lead Sponsor	Collaborator
Stanford University	National Institute of Mental Health (NIMH)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Onset of depression	participants are interviewed in an 18-month follow-up session	18 months	No