Depression Clinical Trial
Official title:
Effect of Aerobic Training on Psychosocial Morbidity, Symptoms, Airway Inflammation and Autonomic Modulation in Asthmatic Patients
The investigators hypothesize that aerobic training can reduce anxiety, depression and airway inflammation and those benefits may be related to changes in autonomic system.
One-hundred patients with moderate or severe persistent asthma, age ranging from 20 to 50
years-old recruited after a medical consultation. Asthma diagnosis based on GINA1 and
patients were under medical treatment for at least 6-months and considered clinically stable
(no crises and changes in medication for at least 30 days). Patients diagnosed with
cardiovascular, pulmonary or musculoskeletal diseases impairing exercise training were
excluded.
Experimental Design: Patients were studied between 2 medical consultation to avoid changes
in medication during the study and patients were randomized (by drawing lots) into either
Control or Training groups. CG was submitted to a 4-hour educational program and a breathing
exercise program and TG was submitted to the same CG procedures plus an aerobic training
program individually based on VO2max. Before and after the intervention, patients performed
pulmonary function test and cardiopulmonary exercise testing and as well as fulfilled
questionnaires to quantify asthma specific HRQL and anxiety and depression levels. Asthma
daily symptoms were evaluated monthly.
;
Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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