Depression Clinical Trial
Official title:
fMRI Studies of Emotional Circuitry in Major Depression
This study will examine activation of a brain circuit that regulates emotion in depressed patients before and after treatment to see which areas of the brain are involved in chronic depression.
Major depressive disorder can be a recurrent problem for many people, interfering with their
ability to function normally in day-to-day life. Although research shows that activation in
certain brain areas corresponds to certain emotional functions, it is not well known which
specific changes in brain functioning are related to or caused by depression. A proposed
theory holds that depression is related to abnormal regulation of emotions and thoughts. This
study will focus particularly on a brain circuit involved in emotional regulation, which
includes the amygdala, the affective division of the anterior cingulate (ACad), and
dorsolateral prefrontal cortex (DLPFC). The amygdala detects critical emotional information,
especially threats; the ACad judges relevance of motivational cues, detects conflict, and
regulates emotional responses; and the DLPFC has a critical role in supporting a wide range
of cognitive control functions. This study will compare brain scans from people with and
without depression to attempt to clarify which changes in brain functioning are related to
depression.
Participation in this study will last 8 weeks. All participants will undergo initial
screening in a telephone interview, then a diagnostic interview and brief physical
examination. After passing through screening, participants will schedule a functional
magnetic resonance imaging (fMRI) scan. The fMRI scan, lasting approximately 2 hours, will
take pictures of both brain structure and brain functioning during different tasks. Also at
this visit but outside the fMRI scanner, participants will be asked to complete an additional
2 hours of tasks on a computer. Depressed participants will then be given Lexapro, an
approved drug for the treatment of depression. Participants taking Lexapro will go to
scheduled doctor's visits after 2, 4, and 6 weeks of treatment to assess health,
effectiveness of the drug, and side effects. On the eighth week, all participants will again
undergo fMRI scanning and computer testing. At both the initial and follow-up fMRI study
visits, images of brain function and anatomy will be recorded, heart rate will be monitored,
and anxiety and arousal will be measured in the computer tests.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT05777044 -
The Effect of Hatha Yoga on Mental Health
|
N/A | |
Recruiting |
NCT04680611 -
Severe Asthma, MepolizumaB and Affect: SAMBA Study
|
||
Recruiting |
NCT04977232 -
Adjunctive Game Intervention for Anhedonia in MDD Patients
|
N/A | |
Recruiting |
NCT04043052 -
Mobile Technologies and Post-stroke Depression
|
N/A | |
Completed |
NCT04512768 -
Treating Comorbid Insomnia in Transdiagnostic Internet-Delivered Cognitive Behaviour Therapy
|
N/A | |
Recruiting |
NCT03207828 -
Testing Interventions for Patients With Fibromyalgia and Depression
|
N/A | |
Completed |
NCT04617015 -
Defining and Treating Depression-related Asthma
|
Early Phase 1 | |
Recruiting |
NCT06011681 -
The Rapid Diagnosis of MCI and Depression in Patients Ages 60 and Over
|
||
Completed |
NCT04476446 -
An Expanded Access Protocol for Esketamine Treatment in Participants With Treatment Resistant Depression (TRD) Who do Not Have Other Treatment Alternatives
|
Phase 3 | |
Recruiting |
NCT02783430 -
Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease
|
Phase 2/Phase 3 | |
Recruiting |
NCT05563805 -
Exploring Virtual Reality Adventure Training Exergaming
|
N/A | |
Completed |
NCT04598165 -
Mobile WACh NEO: Mobile Solutions for Neonatal Health and Maternal Support
|
N/A | |
Completed |
NCT03457714 -
Guided Internet Delivered Cognitive-Behaviour Therapy for Persons With Spinal Cord Injury: A Feasibility Trial
|
||
Recruiting |
NCT05956912 -
Implementing Group Metacognitive Therapy in Cardiac Rehabilitation Services (PATHWAY-Beacons)
|
||
Completed |
NCT05588622 -
Meru Health Program for Cancer Patients With Depression and Anxiety
|
N/A | |
Recruiting |
NCT05234476 -
Behavioral Activation Plus Savoring for University Students
|
N/A | |
Active, not recruiting |
NCT05006976 -
A Naturalistic Trial of Nudging Clinicians in the Norwegian Sickness Absence Clinic. The NSAC Nudge Study
|
N/A | |
Enrolling by invitation |
NCT03276585 -
Night in Japan Home Sleep Monitoring Study
|
||
Completed |
NCT03167372 -
Pilot Comparison of N-of-1 Trials of Light Therapy
|
N/A | |
Terminated |
NCT03275571 -
HIV, Computerized Depression Therapy & Cognition
|
N/A |