Depression Clinical Trial
Official title:
Memantine for Enhancement of Rehabilitation Efficacy and Prevention of Major Depressive Disorder in Older Adults
Verified date | December 2017 |
Source | University of Pittsburgh |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study will evaluate the effectiveness of memantine in improving rehabilitation outcomes and preventing major depressive disorder in older adults who have been admitted to a rehabilitation hospital for a hip fracture or cardiopulmonary condition.
Status | Completed |
Enrollment | 35 |
Est. completion date | June 2009 |
Est. primary completion date | June 2009 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 60 Years and older |
Eligibility |
Inclusion Criteria: - Admission to a skilled nursing facility for rehabilitation within 3 months of recent disabling medical event (e.g., hip fracture) - Medically stable (e.g., no active seizures, delirium, unstable pulse/blood pressure) Exclusion Criteria: - Aphasia or cognitive impairments sufficiently severe to prevent valid assessment (e.g., a score of less than 22 on the Mini Mental State Examination) - Current major depressive episode - History of or current psychosis or mania - Current substance or alcohol abuse or dependence (within 3 months of study entry) - Current use of memantine - Sensitivity or contraindication to memantine - End-stage kidney, liver, heart, or lung disease - Recent hemorrhagic stroke - A FIM score of greater than 70 (on a 91 point scale) |
Country | Name | City | State |
---|---|---|---|
United States | University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
Eric Lenze | National Institute of Mental Health (NIMH) |
United States,
Lenze EJ, Skidmore ER, Begley AE, Newcomer JW, Butters MA, Whyte EM. Memantine for late-life depression and apathy after a disabling medical event: a 12-week, double-blind placebo-controlled pilot study. Int J Geriatr Psychiatry. 2012 Sep;27(9):974-80. do — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Depressive Symptoms | Hamilton depression rating scale ; scale ranges 0 (no symptoms) to 52 (severe depression) | week 0, week 12 | |
Secondary | Incidence of Major Depressive Disorder | cumulative incidence over 12 weeks of follow-up | week 12 | |
Secondary | Functional Recovery | Functional Independence Msure, 13-item motor subscale (scale ranges 13-91, higher scores = better function) | week 0, week 12 |
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