Saliva Profiles in Children With Congenital Heart Disease

Dental Caries Clinical Trial

Official title:

Saliva Profiles in Children With Congenital Heart Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03457974
• Other study ID #: 2010/1109-378
• Status: Completed
• Phase: N/A
• First received: February 23, 2018
• Last updated: March 1, 2018
• Start date: January 1, 2011
• Est. completion date: January 1, 2012

Study information

• Verified date: March 2018
• Source: Istanbul University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study was to evaluate whether there are relationships between the salivary oxidative stress status of children with CHD directly dental caries including gender, age, salivary flow rate, salivary pH, salivary buffering capacity and drug intake such as angiotensin-converting enzyme (ACE) inhibitors. If such relationships exist, they might be employed to patient caries -prevention treatment.

Description:

Using heart failure medications may cause low salivary pH and buffering capacity.As improved oral health is a priority for cardiac patients, it is necessary that they attend dental clinics for regular follow up.

This cross sectional study was carried out with 42 CHD and 42 healthy children who applied to Istanbul University, Faculty of Dentistry, Department of Pedodontics. Gender, age, general health and medications, and caries scores (dfs/DMFS) were recorded. Unstimulated saliva was collected from the participants and were assessed for the salivary secretion rate, salivary buffering capacity, pH, protein levels, superoxide dismutase (SOD), ferric reducing antioxidant power (FRAP), the thiobarbituric acid reactive substances (TBARS), protein carbonyl, protein thiols, total sialic acid.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 84
• Est. completion date: January 1, 2012
• Est. primary completion date: January 1, 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 3 Years to 12 Years

Eligibility

Inclusion Criteria:

• 3-12 years

• Caridac problems

Exclusion Criteria:

• other ages

• syndromes

• other systemic diseases

Related Conditions & MeSH terms

• Cardiac Disease
• Dental Caries
• Heart Defects, Congenital
• Heart Diseases

Intervention

Other:
• saliva
salivary secretion rate, salivary buffering capacity, pH, protein levels, superoxide dismutase (SOD), ferric reducing antioxidant power (FRAP), the thiobarbituric acid reactive substances (TBARS), protein carbonyl, protein thiols, total sialic acid.

Locations

Country	Name	City	State
n/a

Sponsors (6)

Lead Sponsor	Collaborator
Istanbul University	Ezel Uslu, Figen Seymen, Merve Bayram, Sule Batu, Yegane Güven

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	protein carbonyl	protein carbonyl	2 hour
Other	protein thiols	protein thiols	2 hour
Other	total sialic acid	total sialic acid	2 hour
Primary	salivary secretion rate	salivary secretion rate	2 hour
Primary	salivary buffering capacity	salivary buffering capacity	2 hour
Primary	pH	pH	2 hour
Secondary	protein levels of saliva	protein levels	2 hour
Secondary	superoxide dismutase (SOD)	superoxide dismutase (SOD)	2 hour
Secondary	ferric reducing antioxidant power (FRAP)	ferric reducing antioxidant power (FRAP)	2 hour
Secondary	the thiobarbituric acid reactive substances (TBARS)	the thiobarbituric acid reactive substances (TBARS)	2 hour