Cystic Fibrosis-related Diabetes Clinical Trial
Official title:
Sensitivity and Specificity of Different Methods for Cystic Fibrosis-related Diabetes Screening.
Cystic fibrosis-related diabetes is a late cystic fibrosis (CF) associated comorbidity whose
prevalence is increasing sharply lifelong. Guidelines for glucose metabolism (GM) monitoring
relies on oral glucose tolerance test . However, this test is neither sensitive nor specific.
The aim of this study is to compare sensitivity and specificity of different methods for GM
monitoring in children and adolescents with CF.
Continuous GM system (CGMS) will be used as the reference method. Results will be compared to
those of oral glucose tolerance test (OGTT), intravenous glucose tolerance test (IGTT),
homeostasis model assessment index of insulin resistance (HOMA-%IR) , homeostasis model
assessment index of beta-cell function (HOMA-%B) and HbA1C dosage (glycated haemoglobin A1C).
Patients will be classified into three groups according to CGMS: normal glucose tolerance,
impaired glucose tolerance and diabetes mellitus.
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