COVID Clinical Trial
— SequelaeCovOfficial title:
SequelaeCov: a Prospective Study on Lung Damage Caused by SARS-CoV-2 Pneumonia
NCT number | NCT04435327 |
Other study ID # | SequelaeCov |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | October 5, 2020 |
Est. completion date | March 18, 2022 |
Verified date | January 2022 |
Source | University of Milano Bicocca |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Pneumonia is a recurrent element of COVID-19 infection, it is often associated with development of respiratory failure and patients frequently need various degrees of oxygen therapy up to non invasive ventilation (NIV-CPAP) and invasive mechanical ventilation (IMV). Main purpose of this study is to evaluate with non invasive clinical instruments (pletysmography, Diffusion lung capacity for carbon monoxide -DLCO-, six minute walking test and dyspnea scores) and radiological tools (chest X-ray and chest CT scan) the development of medium-to-long term pulmonary sequelae caused by SARS-CoV-2 pneumonia.
Status | Completed |
Enrollment | 300 |
Est. completion date | March 18, 2022 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - Age = 18 and = 80 years - Able to sign informed consent to participate in the study - Real time PCR diagnosis od SARS-CoV-2 infection - Hospital admission due to clinical/instrumental diagnosis of interstitial pneumonia - Presence of acute respiratory failure (PaO2/FiO2 <300 mm Hg) at the moment of hospital admission Exclusion Criteria: - Severe renal failure defined as glomerular filtration rate (GFR) < 30 ml/min at hospital discharge - Cardiovascular failure NYHA class IV (patient unable to perform any activity) at hospital discharge - Active solid or hematological malignancies at hospital discharge - Prior diagnosis of chronic obstructive pulmonary disease (COPD), pulmonary emphysema, pulmonary fibrosis, bronchiectasis associated or not associated to cystic fibrosis - Pregnancy or breastfeeding - Suspected bacterial or fungine pulmonary superinfection during hospital stay |
Country | Name | City | State |
---|---|---|---|
Italy | San Gerardo Hospital | Monza | MB |
Lead Sponsor | Collaborator |
---|---|
University of Milano Bicocca |
Italy,
Faverio P, Luppi F, Rebora P, Busnelli S, Stainer A, Catalano M, Parachini L, Monzani A, Galimberti S, Bini F, Bodini BD, Betti M, De Giacomi F, Scarpazza P, Oggionni E, Scartabellati A, Bilucaglia L, Ceruti P, Modina D, Harari S, Caminati A, Valsecchi MG — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Reduction of Diffusion of Lung CO (DLCO, single breath technique) | Reduction below 80% of predicted values of DLCO | T1 at 6 months from discharge | |
Primary | Reduction of Diffusion of Lung CO (DLCO, single breath technique) | Reduction below 80% of predicted values of DLCO | T2 at 12 months from discharge | |
Secondary | Alterations in 6 minute walking test (6MWT) | reduction in maximum distance walked | T1 at 6 months from discharge | |
Secondary | Alterations in 6 minute walking test (6MWT) | reduction in maximum distance walked | T2 at 12 months from discharge | |
Secondary | Alterations in 6 minute walking test (6MWT) | reduction in oxygen saturation nadir | T1 at 6 months from discharge | |
Secondary | Alterations in 6 minute walking test (6MWT) | reduction in oxygen saturation nadir | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | reduction of Forced Vital Capacity (FVC, %) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | reduction of Forced Vital Capacity (FVC, %) | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | reduction of Forced Vital Capacity (FVC, L) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | reduction of Forced Vital Capacity (FVC, L) | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | reduction of Vital Capacity (VC, %) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | reduction of Vital Capacity (VC, %) | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | reduction of Vital Capacity (VC, L) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | reduction of Vital Capacity (VC, L) | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | reduction of Forced Expiratory Volume in the 1st second (FEV1, L) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | reduction of Forced Expiratory Volume in the 1st second (FEV1, %) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | reduction of Forced Expiratory Volume in the 1st second (FEV1, L) | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | reduction of Forced Expiratory Volume in the 1st second (FEV1, L%) | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | reduction of Total Lung Capacity (TLC, L) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | reduction of Total Lung Capacity (TLC, %) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | reduction of Total Lung Capacity (TLC, L) | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | reduction of Total Lung Capacity (TLC, %) | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | alterations of Residual Volume (RV,%) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | alterations of Residual Volume (RV, L) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | alterations of Residual Volume (RV, L) | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | alterations of Residual Volume (RV, %) | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | increase of Specific Airway Resistance (sRAW) (absolute value) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | increase of Specific Airway Resistance (sRAW) (%) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | increase of Specific Airway Resistance (sRAW) (absolute value) | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | increase of Specific Airway Resistance (sRAW) (%) | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | alterations of Motley Index (VR/CPT) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | alterations of Motley Index (VR/CPT) | T2 at 12 months from discharge | |
Secondary | Alterations of pletismography | alterations of Tiffeneau Index (IT) | T1 at 6 months from discharge | |
Secondary | Alterations of pletismography | alterations of Tiffeneau Index (IT) | T2 at 12 months from discharge | |
Secondary | Alterations of Arterial Blood Gas Analysis | reduction of PaO2 mmHg | T1 at 6 months from discharge | |
Secondary | Alterations of Arterial Blood Gas Analysis | reduction of PaO2 mmHg | T2 at 12 months from discharge | |
Secondary | Alterations of Arterial Blood Gas Analysis | alteration of PaCO2 mmHg | T1 at 6 months from discharge | |
Secondary | Alterations of Arterial Blood Gas Analysis | alteration of PaCO2 mmHg | T2 at 12 months from discharge | |
Secondary | Abnormal Dyspnea Score | Modified Medical Research Council - mMRC > 0 (minimum 0, maximum 4; higher score means worse outcome) | T1 at 6 months from discharge | |
Secondary | Abnormal Dyspnea Score | Modified Medical Research Council - mMRC > 0(minimum 0, maximum 4; higher score means worse outcome) | T2 at 12 months from discharge | |
Secondary | Presence and extension of abnormal pulmonary lung sounds at auscultation | Presence and extension of abnormal pulmonary lung sounds at auscultation | T1 at 6 months from discharge | |
Secondary | Presence and extension of abnormal pulmonary lung sounds at auscultation | Presence and extension of abnormal pulmonary lung sounds at auscultation | T2 at 12 months from discharge | |
Secondary | Presence and extension of radiological alterations at chest X-ray | Presence and extension of radiological alterations at chest X-ray | T1 at 6 months from discharge | |
Secondary | Presence and extension of radiological alterations at chest CT scan | Presence and extension of radiological alterations at chest CT scan | T2 at 12 months from discharge |
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