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NCT ID: NCT04857866 Completed - Clinical trials for Safety in Healthy Volunteers

Safety, Tolerability and PK of a Single Subcutaneous Injection of XmAb27564 in Healthy Volunteers

Start date: April 19, 2021
Phase: Phase 1
Study type: Interventional

This is a Phase 1, randomized, double-blind, placebo-controlled, single ascending-dose study of subcutaneously administered XmAb27564 or placebo in healthy male and female subjects.

NCT ID: NCT04857827 Completed - Clinical trials for Normal Tension Glaucoma (NTG)

A Study to Evaluate Safety and Tolerability of QLS-101 in NTG

Start date: September 15, 2021
Phase: Phase 2
Study type: Interventional

A randomized active-controlled multi-site double-masked 28 day study to evaluate the safety and tolerability of QLS-101 versus timolol maleate Preservative Free (PF) 0.5% ophthalmic solution in subjects with normal tension glaucoma

NCT ID: NCT04857697 Completed - Clinical trials for Anatomic Stage III Breast Cancer AJCC v8

Effects of Probiotics on the Gut Microbiome and Immune System in Operable Stage I-III Breast or Lung Cancer

Start date: July 1, 2021
Phase: Early Phase 1
Study type: Interventional

This clinical trial evaluates whether engineering gut microbiome using probiotics will alter the body's immune system to react to stage I-III breast or lung cancers that can be removed by surgery (operable). Having diverse species of bacteria inside the bowel may help improve the immune system, particularly the ability of the immune system to recognize cancer. Taking probiotics may change the diversity and make up of the bacteria in the bowels, and change how the immune system reacts to breast or lung cancer.

NCT ID: NCT04857606 Completed - Clinical trials for Non-alcoholic Fatty Liver Disease

Single Ascending Dose of AMG 609 in Participants With Non-alcoholic Fatty Liver Disease

Start date: May 24, 2021
Phase: Phase 1
Study type: Interventional

This study aims to assess the safety and tolerability of AMG 609 when administered subcutaneously as single doses in participants with non-alcoholic fatty liver disease (NAFLD).

NCT ID: NCT04857515 Completed - Smoking Cessation Clinical Trials

Clinical Learning Study for a Mobile Smoking Cessation Program

Start date: March 12, 2021
Phase:
Study type: Observational

The purpose of this study are to obtain learnings regarding the Digital Therapeutic (DTx) experience of Clickotine, including acceptability and preference of the overall program and specific DTx components, as well as to obtain learnings related to adult participants' use of the DTx for smoking cessation.

NCT ID: NCT04857437 Completed - Clinical trials for Non-Alcoholic Fatty Liver Disease

Study in Healthy Adults Evaluating PF-07202954

Start date: May 13, 2021
Phase: Phase 1
Study type: Interventional

The study is planned as a 3 part design with investigator and participant blinded (sponsor-open), placebo controlled, randomized, dose escalation in Part 1 and Part 2; and a randomized, open label design, in Part 3 (if conducted).

NCT ID: NCT04857411 Completed - Clinical trials for Diabetes Mellitus, Type 2

Peers LEAD Plus Healthy Living With Diabetes (HLWD)

Start date: April 19, 2021
Phase: N/A
Study type: Interventional

The specific goal of this project is to decrease diabetes-related morbidity among African Americans (AAs) in Milwaukee through the integration of Peers LEAD, a culturally-appropriate program to increase medication adherence into Healthy Living with Diabetes (HLWD), an existing diabetes self-management program.

NCT ID: NCT04857320 Completed - Clinical trials for Pharmacodynamic Response to Small Doses of Insulin

Transdermal Insulin Response In Healthy Volunteers

Start date: March 12, 2021
Phase: Early Phase 1
Study type: Interventional

Bio-fermentation produced Human insulin is available without prescription in the U.S. This study is a physician-initiated trial of a formula enabling transdermal delivery of human insulin.

NCT ID: NCT04857307 Completed - Epilepsy Clinical Trials

A Study to Assess the Pharmacokinetics (PK) and Safety of Staccato Alprazolam in Adolescent Study Participants With Epilepsy

Start date: April 28, 2021
Phase: Phase 1
Study type: Interventional

The purpose of the study is to assess the pharmacokinetics (PK), tolerability, and safety of Staccato alprazolam in adolescent study participants with epilepsy following single-dose administration.

NCT ID: NCT04857281 Completed - Gastroparesis Clinical Trials

Non-invasive Vagal Nerve Stimulation (nVNS) for Symptomatic Exacerbation of Nausea in Patients With Gastroparesis and Related Disorders

nVNS
Start date: April 19, 2021
Phase: N/A
Study type: Interventional

The hypothesis of this pilot study is that nVNS will result in relief of nausea by modulation of vagal nerve activity. nVNS is the first non-invasive, handheld medical device applied on the side of the neck and sends gentle, patented mild electrical stimulation through the skin to activate the vagus nerve. nVNS offers a potential alternative to Gastric electrical stimulation (GES) that could eliminate significant risks of injury or illness or identify likely responders to implantable neurostimulator including implanted VNS (iVNS). nVNS could provide a more effective and safer alternative to the use of traditional rescue medications.