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NCT ID: NCT00310388 Terminated - Epilepsy Clinical Trials

Open-Label Extension Study of the Phase 3 VRX-RET-E22-302 Double-Blind Trial. 115097

Start date: July 5, 2006
Phase: Phase 3
Study type: Interventional

This Phase 3 trial is an open-label extension study of the placebo-controlled, double-blind VRX-RET-E22-302 trial. Patients who have completed the VRX-RET-E22-302 trial and who meet inclusion and exclusion criteria will be treated with 600-1200 mg/day of retigabine as an adjunct therapy to their current antiepileptic drugs (AEDs) or vagal nerve stimulation. Treatment will be continued until the subject withdraws from the study or until the program is discontinued. Patients will be recruited from 55-60 sites in Europe, Israel, Australia, and South Africa. The primary objective of the study is to evaluate the safety and tolerability of long-term therapy with retigabine administered as adjunctive therapy in adult epilepsy patients with partial-onset seizures, who completed the double-blind Study VRX-RET-E22-302. Secondary objectives are: to evaluate efficacy of long-term treatment with retigabine and patient quality of life and to evaluate whether retinal pigmentation, unexplained vision loss, pigmentation of non-retinal ocular tissue, and discoloration of nails, lips, skin or mucosa change over time after discontinuation of retigabine.

NCT ID: NCT00295165 Terminated - Crohn Disease Clinical Trials

Efficacy (Induction of Response/Remission) and Safety Study in Patients With Moderate to Severe Crohn's Disease

Start date: January 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate if Leukine can induce clinical response or remission in patients with Crohn's disease.

NCT ID: NCT00279435 Terminated - Ulcerative Colitis Clinical Trials

Study of Visilizumab Versus Placebo in Subjects With Intravenous Steroid-refractory Ulcerative Colitis Previously Responsive in a Visilizumab Study

Start date: August 2006
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to compare the efficacy, safety, pharmacokinetics, and immunogenicity in subjects retreated with visilizumab or placebo after a response in a prior visilizumab study.

NCT ID: NCT00279422 Terminated - Ulcerative Colitis Clinical Trials

A Study of Visilizumab in Subjects With Intravenous Steroid-Refractory Ulcerative Colitis

Start date: February 2006
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to compare the efficacy of visilizumab to placebo in subjects with intravenous steroid-refractory ulcerative colitis.

NCT ID: NCT00269828 Terminated - NSCLC Clinical Trials

A Survival Study for Women With Advanced Lung Cancer Who Have Not Previously Received Chemotherapy.

PIONEER
Start date: December 2005
Phase: Phase 3
Study type: Interventional

This is a randomized, open-label, multinational, phase III study in women with histologically- or cytologically-confirmed advanced NSCLC who are chemotherapy naïve and have PS 2. Study drug will be administered on day 1 of each 21 day cycle

NCT ID: NCT00267553 Terminated - Breast Neoplasms Clinical Trials

Treatment and Survival Continuation Study of Atamestane Plus Toremifene vs Letrozole in Advanced Breast Cancer

Start date: November 2005
Phase: Phase 3
Study type: Interventional

Protocol 777-CLP-32 is the treatment and survival continuation protocol of Biomed 777-CLP-29, and will continue to compare combined hormonal therapy using the experimental aromatase inhibitor (AI) atamestane combined with the FDA-approved anti-estrogen toremifene (Fareston®), to the single agent FDA-approved aromatase inhibitor letrozole (Femara®) for the treatment of advanced breast cancer. The purpose of this study is to determine whether maximal estrogen suppression achieved via the combination of atamestane, plus toremifene (Fareston®), is more effective than letrozole (Femara®) in delaying the growth of breast cancer.

NCT ID: NCT00265382 Terminated - Schizophrenia Clinical Trials

Safety And Tolerability Of Ziprasidone In Adolescents With Schizophrenia

Start date: June 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the safety and tolerability of ziprasidone during long-term open-label administration in adolescents (ages 13-17) with schizophrenia.

NCT ID: NCT00257192 Terminated - Schizophrenia Clinical Trials

Safety And Efficacy Of Ziprasidone In Adolescents With Schizophrenia

Start date: April 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine if flexibly-dosed ziprasidone is safe and effective for the treatment of adolescents (ages 13-17) with schizophrenia

NCT ID: NCT00206700 Terminated - Crohn Disease Clinical Trials

Open-label Trial of Leukine in Active Crohn's Disease

Start date: February 2003
Phase: Phase 2
Study type: Interventional

The purpose of this study is to establish a safety profile sargramostim administered in 8 week cycles to adult patients with active Crohn's disease.

NCT ID: NCT00124891 Terminated - Arrhythmias Clinical Trials

Study Evaluating GAP-486 in Non-sustained Ventricular Tachycardia

Start date: June 1, 2005
Phase: Phase 2
Study type: Interventional

To determine whether the administration of test article will decrease the occurrence of ventricular arrhythmias in patients who have acute coronary syndrome (unstable angina, ST segment elevated myocardial infarction or myocardial infarction without ST elevation).