There are about 15072 clinical studies being (or have been) conducted in Turkey. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
Background: Since the first day of the epidemic, people diagnosed with COVID-19 and their relatives, some countries and groups such as healthcare professionals are exposed to discriminatory behavior and stigmatization in the world. Nurses fighting in the front lines from the very beginning of the epidemic and interacting with the patient the most experience anxiety and are exposed to stigma. Aim: With this study, it was aimed to determine the stigma, anxiety and wise awareness levels of nurses in our country according to their COVID-19 experience and to determine their effect on their professional lives. Methods: The universe of this case-control study, which will determine the level of stigma, anxiety and wise awareness of those who work as nurses in the clinic according to their COVID-19 passing status, is the universe of T.C. Nurses working at Ministry of Health Health Sciences University Bursa Yüksek İhtisas Training and Research Hospital Internal and Surgical Clinics (N: 756). The sample calculation of the research was calculated using the sampling method with known universe. The minimum number of people in the sample was calculated as (n) 354 when 1% error and 99% confidence interval were taken with the Raosoft sampling method. It was planned to reach the total number of nurses selected from internal and surgical clinics by using simple random sampling method and to collect data from these clinics between 15.05.2021 - 15.06.2021. In this study, socio-demographic information and questions about COVID-19, the Effect of COVID-19 Pandemic on Professional Life, "Coronavirus Anxiety Scale" and Toronto Wisdom Awareness Scale will be used in this study.
While the rate of inguinal hernia repair operations in England is 10 per 100,000 people. The rate in the United States is found to be 28 per 100,000 people. Today, the effectiveness between open repair and laparoscopic repair in inguinal hernia repair is still debated. Laparoscopic approach offers many advantages over open repair. Regional blocks have an important place in the multi-modal anesthesia approach applied to reduce postoperative pain. In this sense, the Transversus Abdominis Plane Block (TAPB) emerges as an effective regional anesthesia method that reduces postoperative pain. This method can be applied with the help of ultrasound or laparoscopy. The aim of this study is to compare the ultrasound-assisted TAPB application and Laparoscopy-assisted TAPB application in Total Extraperitoneal hernia repair (TEP) to reveal the effects of postoperative pain. A total of 60 patients will be included in the study; 30 of these patients will be injected with local anesthetic into the fascia between the transversus abdominis and internal oblique muscles with the help of ultrasound from the designated area (Before the operation starts, TAPB with 20 ml 0.25 % bupivacaine will be applied to the surgical side under ultrasonography); In the other 30 patients, local anesthetic injection will be made to the same area under laparoscopic direct vision. 50 mg Bupivacaine (0.25 % 20 ml bupivacaine solution) has been determined as the application dose and this amount will be applied in both groups. 10 cm visual analog scale (VAS) will be used in postoperative pain follow-up. 50 mg intravenous tramadol will be administered to patients with VAS > 4 and tramadol will be supplemented to 100 mg in patients with high pain levels after 30 minutes. Oral non-steroidal anti-inflammatory will be given at the postoperative 8th hour. Patients whose pain persists despite current therapy will be given 25 mg of meperidine intravenously as a rescue analgesic. The doses of analgesic administered in the postoperative period and the hours of administration will be recorded
In order to respond correctly to disasters, medical teams must have the necessary training and sufficient equipment. However, in many countries, disaster nursing education is not adequately included in nursing curricula (Kalanlar and Kublai, 2015). This is seen as an important situation affecting the capacity of nurses to respond to disasters. In particular, it is emphasized that providing disaster nursing and management training to nurse students will have positive consequences for disaster-affected individuals and communities, such as reduced death rates, improved health services, and reduced disaster-related costs (Kalanlar and Kublai, 2015). For this reason, disaster preparation of both nurses and student nurses is important for combating disasters. It has been reported that nursing students provide assistance in issues such as monitoring the physical and psychological health of disaster victims, improving hygiene, and health counseling, using the knowledge and skills acquired in vocational education (Kashiwaba and Okudera, 2014; Tomizawa et al., 2014). Some studies have shown that student nurses do not have sufficient knowledge and skills in disaster preparedness and response (Schmidt et al., 2011; Smithers et al., 2020). However, in most schools where the curricula of domestic nursing schools are examined, disaster nursing courses are conducted as electives rather than majors. Despite these limitations, nursing students tops the teams that have a key role in a potential disaster or disaster (Satoh et al., 2016). Therefore, groups that can contribute during disaster response must have sufficient knowledge and skills. Because the lack of experience during intervention leads to stress and fear of intervening in disasters, while the belief that it is adequately prepared for disaster situations increases confidence in intervening in disasters. To overcome the lack of experience in Disaster Response, Education that will provide insight into the reality of disaster response is important. To achieve the goal of training medical personnel capable of disaster response, a variety of training methods are needed, such as not only in-depth theory training, but also Case-Based Learning and practice in simulated situations with a multidisciplinary approach. In this context, the education model that stands out in the literature is the disaster nursing and management model developed by Jening. Jenning's disaster nursing management model was developed directly for Nurse students and describes the nurse's duties at each stage of Disaster Management. It is a model developed to explain disaster nursing to students and to provide them with knowledge about disaster management. In this aspect, the model differs from other disaster management models (Jennings Sanders, 2004). The aim of this research is to evaluate the impact of disaster nursing and management education given to students using Jenning's disaster nursing and management model on general disaster preparedness belief state, disaster response self-efficiency and psychological resilience of students.
NLRC4, an inflammasome , is a cytosolic multiprotein complex involved in the initiation and modulation of the immune response. Periodontitis is a chronic inflammatory disease that can start with localized inflammatory reactions created by the supporting tissues surrounding the teeth against microorganisms and then result in loss of teeth. It has been said that proinflammatory cytokines released in the microenvironment of periodontitis can increase the expression of NLRC4 inflammasome genes. The authors think that NLRC4 may play a role in the periodontitis. The aim of this study is to compare the NLRC4, IL-1β and IL-10 levels of healthy and periodontitis individuals.
Coronavirus disease (Covid-19) is a new public health crisis threatening humanity caused by SARS-CoV-2. Although it originated in China's Hubei province in late 2019, it has spread to many countries around the world. Although Covid-19 first caused infection by affecting the lung, current data showed that the gastrointestinal tract was also affected by detecting viral RNA in Covid-19-infected human intestinal epithelial cells and feces. The association has been confirmed by showing that patients hospitalized with COVID-19 have significant changes in intestinal bacterioma. These changes have been characterized by a significant reduction in gut microbiome (BM) diversity associated with gastrointestinal complaints of the acute phase of infection (e.g. abdominal pain, nausea, vomiting, diarrhea), depletion of beneficial bacterial symbionts, and enrichment of opportunistic pathogens (e.g. Streptococcus, Rothia, Actinomyces). In particular, recent studies have evidence that patients with Covid-19 are more prone to a dysbiosis profile of the gut microbiota, infected individuals present irregular gut microbiota, and even dysbiosis (disruption of microbiota balance) in the gut microbiota. The first case reports reported in China suggested that there was no virus found in amniotic fluid, umbilical cord blood, throat swabs of the newborn, placenta, vaginal fluid, and breast milk samples infected with Covid-19. The latest data indicate that there is no vertical transmission to the fetus, and so far, no viruses have been found in the cord blood of newborns born from Covid-19 positive pregnant women, nasal sampling and amniotic fluid and placentas of pregnant women. However, the effect of intestinal microbial structure affected by Covid-19 on breast milk microbiota and the effect of a dysbiosis to occur on infant health or the effect of the healing properties of breast milk on Covid-19 are still not clearly known. This views are that intestinal microbial colonization originating from the gastrointestinal system affected by Covid-19 will affect breast milk microbial colonization. However, there is no study on this subject. For this purpose, aim in this study was to determine the breast milk microbiome and biologically active proteins (secretory immunoglobulin A (sIgA), lysozyme, lactoferrin, osteoprotegerin (OPG), leptin, adiponectin and β-endorphin (b-) levels of mothers who had Covid-19 with healthy mothers. will be compared.
Pregnants who underwent a web-based preparation for labor program, which was developed based on the health belief model and supported by motivational interviews, had a higher perception of birth self-efficacy than those who did not pass. Pregnant women who underwent a web-based preparation for labor program, which was developed based on a health belief model and supported by motivational interviews, had a more positive perception of birth than those who did not pass. The level of fear experienced at birth is lower in pregnant women who underwent a web-based preparation for labor program, which was developed based on the health belief model and supported by motivational interviews. The frequency of voluntary cesarean delivery is lower in pregnant women who undergo a web-based preparation for labor program, which is developed based on the health belief model and supported by motivational interviews. The frequency of episiotomy is lower in pregnant women who undergo a web-based preparation for labor program, which is developed based on a health belief model and supported by motivational interviews. Induction frequency is lower in pregnant women who underwent a web-based preparation for labor program, which was developed based on the health belief model and supported by motivational interviews, than those who did not pass. Pregnants who underwent a web-based preparation program for labor, which was developed based on the health belief model and supported by motivational interviews, had a shorter delivery period than those who did not pass.
Objective: Sympathetic activity starts to increase during exercise. At the end of the exercise, while sympathetic activation decreases, parasympathetic activity increases. Sympathetic and parasympathetic excursions achieve homeostasis. Most of the parasympathetic activity effects are vagus code. It is aimed to compare the comparison of exercise and vagus therapy in these healthy individuals.
This is a national, multicenter, open-label, randomized, phase II/III trial that evaluates the efficacy and safety of favipiravir and ribavirin in the treatment of patients with confirmed COVID-19 observed within 72 hours. Approximately 100 patients will be randomized in 1:1 ratio and divided into two groups.
Motor imagery is the feeling and thinking that the movement is done by imagination without physically occurring. In addition to its use in various fields, its use in the field of physiotherapy is also increasing. Especially in situations where real movement is difficult or contraindicated, motor visualization is very advantageous when there is no physical contact. Swallowing function is one of the vital functions that ensure human independence. Like many components in swallowing, tongue muscle is also important. It has been shown that the strength of the tongue decreases with age, disease or other reasons. In the development of the strength of the tongue, while physiological principles are taken as basis, a different procedure from normal procedures is performed. However, language is a part of the body where one can study on his own. Such situations lead to research on whether language reinforcement can occur with motor imagery. Considering that in addition to long-term effects, acute effects may also affect the functions of individuals, the starting point of the study is formed. Studies have investigated the acute change in tongue strength and pain perception after motor imagery. The primary aim of this study is compare the acute effects of different motor imagery methods and physical exercise on tongue strength and pain in heatlhy adults.
The menstrual cycle is one of the most important signs of a functioning reproductive system in women, but sometimes this cycle is associated with signs and symptoms that cause physical and psychological problems for women. Considering the high prevalence of PMS among women and the complications of this syndrome on work performance, social and interpersonal relationships and family, and its role in limiting education, social and economic progress in society, 8 weeks of online yoga exercises given online to female students were helpful in reducing PMS symptoms The aim was to evaluate the efficacy and effect on inflammation parameters. The study was planned as an interventional, single-blind, randomized controlled study. The sample size of this study was calculated based on the latest research available on the effect of exercise on PMS (Kamalifard et al.2017). A power analysis was performed in student PMS scores between exercise and control groups and to expect a difference of 80% strength and α = 0.50 and 30%. 80% power (1 - ß) minimum 18 students for each group, total 36 students will be included in the sample.