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NCT ID: NCT05276297 Active, not recruiting - Clinical trials for Hepatitis B, Chronic

A Study on the Safety, Efficacy and Immune Response Following Sequential Treatment With an Anti-sense Oligonucleotide Against Chronic Hepatitis B (CHB) and Chronic Hepatitis B Targeted Immunotherapy (CHB-TI) in CHB Patients Receiving Nucleos(t)Ide Analogue (NA) Therapy

Start date: March 22, 2022
Phase: Phase 2
Study type: Interventional

This study will assess the safety, efficacy and immune response following the sequential treatment of GlaxoSmithKline's (GSK) ASO compound (GSK3228836) and CHB-TI (GSK3528869A) in participants 18 to 65 years stable on NA treatment for CHB. The aim is to quantify the efficacy of sequential therapy as well as to determine an added value of sequential therapy over GSK3228836 therapy in CHB patients treated with NAs. In addition, the study will assess the effect of different treatment durations of GSK3228836 (12 or 24 weeks) prior to initiating GSK3528869A treatment.

NCT ID: NCT05275023 Active, not recruiting - Clinical trials for Hepatitis B, Chronic

An Efficacy and Safety Study of a Combination of JNJ-73763989, Nucleos(t)Ide Analogs (NA), and a Programmed Cell Death Protein Receptor-1 (PD-1) Inhibitor in Chronic Hepatitis B Participants

OCTOPUS-1
Start date: June 30, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate efficacy of the study intervention, based on hepatitis B surface antigen (HBsAg) levels at follow-up (FU) Week 24.

NCT ID: NCT05274282 Active, not recruiting - Clinical trials for Attention Deficit Disorder With Hyperactivity

Effects of Animation Therapy on Children With ADHD

Start date: May 15, 2023
Phase: N/A
Study type: Interventional

The aim of the study is to determine the effects of animation therapy on the main symptoms of Attention Deficit - Hyperactivity Disorder; hyperactivity, inattention and impulsivity.

NCT ID: NCT05272345 Active, not recruiting - Fibromyalgia Clinical Trials

Fibromyalgia and Sexual Functıonal Dısorder and Sexual Therapy

Start date: February 14, 2022
Phase: N/A
Study type: Interventional

investigators aim to re-evaluate the findings of Fibromyalgia in patients whose FSFI scores return to normal levels after sexual therapy, by identifying patients with sexual dysfunction according to the FSFI scale applied in patients investigators followed up with a diagnosis of fibromyalgia, and when investigators consulted with obstetricians.

NCT ID: NCT05269004 Active, not recruiting - Multiple Sclerosis Clinical Trials

A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis

OLERO
Start date: May 3, 2022
Phase: Phase 3
Study type: Interventional

This is a Phase IIIb, single-arm, multicenter, OLE study. Participants receiving ocrelizumab as an investigational medicinal product (IMP) in a Roche sponsored Parent study who continue to receive ocrelizumab or are in safety follow-up at the time of the closure of their respective Parent study (WA21092, WA21093 or WA25046) are eligible for enrollment in this extension study. Participants who will continue ocrelizumab treatment will receive IMP based on the dosage and administration received at the time of rollover from the Parent study.

NCT ID: NCT05267210 Active, not recruiting - Back Pain Clinical Trials

Turkish Translation, Validity and Reliability of the Back Pain and Body Posture Assessment Questionnaire

Start date: October 2, 2021
Phase:
Study type: Observational [Patient Registry]

The Adult Back Pain and Body Posture Assessment Instrument (BackPDE-Y), whose validity and reliability is planned, will be applied. This assessment scale will be translated into Turkish by two native Turkish speakers, one who is fluent in English.

NCT ID: NCT05262023 Active, not recruiting - Clinical trials for Frontotemporal Dementia

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN)

Start date: February 1, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

This is a Phase 1/2, multicenter, randomized, placebo-controlled, double-blind study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple doses of DNL593 in two parts followed by an optional open-label extension (OLE) period. Part A will evaluate the safety, tolerability, PK, and PD of single doses of DNL593 in healthy male and healthy female participants of nonchildbearing potential. Part B will evaluate the safety, tolerability, PK, and PD of multiple doses of DNL593 in participants with frontotemporal dementia (FTD) over 25 weeks. Part B will be followed by Part C, an optional 18-month OLE period available for all participants who complete Part B.

NCT ID: NCT05257252 Active, not recruiting - Nurse's Role Clinical Trials

The Effect of "Persons With Disability Friendly Nursing Education Program"

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this research; The aim of this study is to measure the effect of the Persons With Disability Friendly Nursing Education Program developed based on the Story Theory on the empathic tendencies of senior nursing students towards persons with disability and their perceptions of competence of senior nursing students to care for persons with disability. In the research, a multi-stage evaluation design from mixed method research will be used. Focus group interviews will be conducted before and after the program in the qualitative dimension of the research, while the randomized controlled double-blind pretest-posttest control group experimental design will be used in the quantitative dimension. The data of the research will be collected in the Department of Nursing of the Faculty of Health Sciences of Ondokuz Mayis University in Samsun, Turkey.

NCT ID: NCT05256654 Active, not recruiting - Dyslipidemias Clinical Trials

A Study of LY3561774 in Participants With Mixed Dyslipidemia

PROLONG-ANG3
Start date: July 20, 2022
Phase: Phase 2
Study type: Interventional

This a multicenter, Phase 2b, double-blind, placebo-controlled, parallel group study to provide data on efficacy and safety of LY3561774 administered subcutaneously at various doses in participants with mixed dyslipidemia and on a stable dose of a statin.

NCT ID: NCT05254119 Active, not recruiting - Clinical trials for Non Small Cell Lung Cancer

DIAGNOSIS, TREATMENT AND OUTCOME OF LUNG CANCER PATIENTS

REGISTURK-LUNG
Start date: December 1, 2021
Phase:
Study type: Observational

Observational, prospective clinical research, multi-center clinical research platform with the main objective to assess molecular biomarker testing, treatment and outcome of patients with NSCLC or SCLC in Turkey