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NCT ID: NCT00641654 Terminated - Chronic Hepatitis C Clinical Trials

Combination Therapy With Pegylated Interferon and Ribavirin in Patients With Chronic Hepatitis C Genotype 2 or 3 Infection Who Previously Have Relapsed After Therapy With Pegylated Interferon and Ribavirin

RelapC
Start date: January 2007
Phase: Phase 4
Study type: Interventional

To evaluate the efficacy of pegylated interferon alfa-2a 40 kD (PEGASYS) combination therapy with ribavirin (Copegus)given for 24 or 48 weeks in patients with chronic hepatitis C (CHC) virus infection genotype 2 or 3 who responded during (i.e. had HCV-RNA <50 IU/mL at the end of previous therapy), but relapsed after (i.e. had detectable HCV-RNA after the end of prior treatment) previous therapy with pegylated interferon and ribavirin given for at least 12 weeks and at most 24 weeks.

NCT ID: NCT00640913 Recruiting - Rectal Cancer Clinical Trials

Early Reversal of Defunctioning Stoma Trial

ELSOR
Start date: February 2008
Phase: N/A
Study type: Observational

In this trial will be investigated if a defunctioning loop stoma used in low anterior resection of the rectum for cancer can be reversed after 14 days instead of 3-12 months which is present clinical practise.

NCT ID: NCT00640848 Completed - Insomnia Clinical Trials

Almorexant in Primary Insomnia

Insomnia
Start date: May 2006
Phase: Phase 1
Study type: Interventional

The aim of the study is to determine the minimum effective dose of ACT-078573 on sleep efficiency and to assess the effects of different doses of ACT-078573 on other PSG parameters.

NCT ID: NCT00640328 Completed - Multiple Sclerosis Clinical Trials

Ofatumumab Dose-finding in Relapsing Remitting Multiple Sclerosis (RRMS) Patients

OMS115102
Start date: May 2008
Phase: Phase 2
Study type: Interventional

The trial consists of a dose escalation, to establish the safety of ofatumumab in RRMS patients. A 48-week treatment period followed by an individualized follow-up period until normalization of peripheral B-cell counts or Immunoglobulin G (IgG) levels.

NCT ID: NCT00639808 Completed - Diabetes Mellitus Clinical Trials

Safety and Efficacy of IV Infusion of Investigational Agent (TZP-101) in Patients With Diabetic Gastroparesis

Start date: August 2006
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine whether TZP-101 is safe in people with diabetes. Also to determine if TZP-101 is effective in increasing the gastric emptying rate in diabetic patients.

NCT ID: NCT00639782 Completed - Heart Valve Disease Clinical Trials

Prospective Randomized On-X Versus SJM Evaluation Trial

PROSE
Start date: July 2003
Phase: N/A
Study type: Interventional

The study hypothesizes that rate of thromboembolic complications of the On-X prosthesis is reduced as compared to the SJM prosthesis.

NCT ID: NCT00637377 Completed - Clinical trials for Macular Degeneration

Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration (AMD)

VIEW 2
Start date: April 2008
Phase: Phase 3
Study type: Interventional

This study is a phase III, double-masked, randomized, study of the efficacy and safety of VEGF Trap-Eye in patients with neovascular age-related macular degeneration. Approximately 1200 patients will be randomized in Europe, Asia, Japan, Australia and South America.

NCT ID: NCT00636948 Completed - Rectal Cancer Clinical Trials

Rectal Cancer Trial On Defunctioning Stoma

RECTODES
Start date: December 1999
Phase: N/A
Study type: Observational

The hypothesis of the present trial was that the use of a defunctioning loop stoma reduces the rate of symptomatic anastomotic leakage from 15% to 7.5% after low anterior resection of the rectum for cancer.

NCT ID: NCT00636857 Recruiting - Hyponatremia Clinical Trials

Postoperative Hyponatremia - Are There Gender Differences?

Start date: March 2008
Phase: N/A
Study type: Interventional

The proposed study will focus on anesthesia and anesthesia-induced hypotension as a possible cause for postoperative fluid retention and hyponatremia, and investigate gender differences in this response.

NCT ID: NCT00636168 Completed - Clinical trials for High Risk Stage III Melanoma

Efficacy Study of Ipilimumab Versus Placebo to Prevent Recurrence After Complete Resection of High Risk Stage III Melanoma

Start date: June 30, 2008
Phase: Phase 3
Study type: Interventional

The purpose of the study is to determine if ipilimumab is effective in preventing or delaying recurrence and prolongs survival after complete resection of high risk stage III melanoma