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NCT ID: NCT00143611 Completed - Sepsis Clinical Trials

Efficacy & Safety of Resatorvid in Adults With Severe Sepsis

Start date: September 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the optimal dose of Resatorvid for reducing 28-day all-cause mortality in subjects with severe sepsis.

NCT ID: NCT00143403 Completed - Clinical trials for Colorectal Neoplasms

Comparing Irinotecan and 5 FU/FA To 5-FU/FA After Resection Of Liver Metastases For Colorectal Cancer

Start date: December 2001
Phase: Phase 3
Study type: Interventional

To see if Disease Free Survival (DFS) is improved when complete surgical resection of liver metastases (R0) is followed by chemotherapy with CPT-11 and 5-FU/FA as FOLFIRI regimen, compared to 5-FU/FA alone.

NCT ID: NCT00143312 Completed - Clinical trials for Prophylaxis Of Invasive Fungal Infections

Voriconazole for Secondary Prophylaxis of Invasive Fungal Infections in Patients With Allogeneic Stem Cell Transplants

VOSIFI
Start date: February 2005
Phase: Phase 4
Study type: Interventional

To prevent recurrence of invasive fungal infection in patients with allogeneic stem cell transplants

NCT ID: NCT00143286 Completed - Smoking Cessation Clinical Trials

A 52-Week Multicenter Study Evaluating the Safety and Efficacy of Varenicline for the Maintenance of Smoking Cessation

Start date: April 2003
Phase: Phase 3
Study type: Interventional

The primary purpose of this study is a comparison of abstinence maintenance in subjects randomized to double-blind varenicline or placebo from Weeks 13 -24 in subjects who responded to an intial 12-week open label course of varenicline, with post-treatment follow-up of smoking status to Week 52.

NCT ID: NCT00143000 Completed - Hepatitis C Virus Clinical Trials

Multicenter Study Evaluating 12 Versus 24 Weeks Therapy With Peginterferon and Ribavirin for Hepatitis C Virus (HCV) Genotype 2 or 3

Start date: April 2004
Phase: Phase 4
Study type: Interventional

The primary objective of the study is to demonstrate that the efficacy of peginterferon alfa-2a 40KD combination therapy with ribavirin in interferon naïve patients with chronic hepatitis C virus infection genotype 2 or 3 given for 12 weeks is non-inferior to 24 weeks.

NCT ID: NCT00141843 Completed - Hemophilia A Clinical Trials

Study to Establish Bioequivalence of ReFacto AF (BDDrFVIII) With Advate (FLrFVIII) in Hemophilia A

Start date: July 2005
Phase: Phase 3
Study type: Interventional

The study will consist of two parts: a safety and efficacy period in which all subjects will participate and a pharmacokinetic analysis period, in which 30 eligible subjects will participate to compare ReFacto AF and Advate bioequivalency and safety and efficacy of ReFacto AF in patients with Hemophilia A.

NCT ID: NCT00141518 Completed - Clinical trials for Advanced Idiopathic Parkinson's Disease

DAPHNE (Duodopa in Advanced Parkinson's: Health Outcomes & Net Economic Impact)

Start date: January 2006
Phase: Phase 4
Study type: Interventional

Health economics long-term study

NCT ID: NCT00141323 Completed - Osteoporosis Clinical Trials

Postmenopausal Evaluation and Risk-reduction With Lasofoxifene (PEARL)

PEARL
Start date: November 2001
Phase: Phase 3
Study type: Interventional

The purpose of the study is to determine the safety and effectiveness of 2 doses of the investigational drug, lasofoxifene, compared to placebo (an inactive substance) in reducing new spinal fractures in women with osteoporosis.

NCT ID: NCT00141245 Completed - Clinical trials for Seizure Disorder, Partial

To Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.

Start date: October 1998
Phase: Phase 3
Study type: Interventional

To evaluate long-term safety and efficacy of pregabalin in patients with partial seizures.

NCT ID: NCT00141193 Completed - Colorectal Adenoma Clinical Trials

Prevention of Colorectal Sporadic Adenomatous Polyps (PRESAP)

PRESAP
Start date: February 2001
Phase: Phase 3
Study type: Interventional

This study is a prospective, randomized, double-blind, placebo-controlled, multi-center trial to compare the efficacy and safety of celecoxib 400mg QD versus placebo in reducing the occurrence of new colorectal adenomas post-polypectomy at Month 13 (Year 1) and Month 37 (Year 3) of study drug administration.