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NCT ID: NCT01143064 Completed - Brain Injuries Clinical Trials

Efficacy and Safety Study of Intravenous Progesterone in Patients With Severe Traumatic Brain Injury

SyNAPSe
Start date: June 2010
Phase: Phase 3
Study type: Interventional

The SyNAPSe trial will study if giving intravenous (i.v.) progesterone within 8 hours of the injury for a total of 120 hours to severe traumatic brain injury patients improves their recovery.

NCT ID: NCT01142726 Completed - Clinical trials for Rheumatoid Arthritis

Efficacy and Safety Study of Abatacept Subcutaneous Plus Methotrexate in Inducing Remission in Adults With Very Early Rheumatoid Arthritis

Start date: December 2010
Phase: Phase 3
Study type: Interventional

The primary purpose of the protocol is to demonstrate the ability of abatacept plus methotrexate to induce remission in patients with very early rheumatoid arthritis after 12 months of treatment and to maintain remission following 6 months of drug withdrawal.

NCT ID: NCT01142193 Completed - Epilepsy Clinical Trials

Study to Evaluate the Safety and Effectiveness of USL255 in Patients With Refractory Partial-onset Seizures

Start date: May 2010
Phase: Phase 3
Study type: Interventional

The purpose of this study is to examine the safety and effectiveness of USL255 as adjunctive therapy in patients with refractory partial onset-seizures.

NCT ID: NCT01139762 Completed - Clinical trials for Benign Prostatic Hyperplasia

A Study of Tadalafil Use With Finasteride in Men With Enlarged Prostates and Urinary Symptoms

Start date: September 2010
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the efficacy and safety of once daily tadalafil when taken with finasteride as a treatment for men with signs and symptoms of Benign Prostatic Hyperplasia and demonstrable prostate enlargement.

NCT ID: NCT01138501 Completed - Clinical trials for Congenital Bleeding Disorder

Safety and Efficacy of Turoctocog Alfa in Previously Treated Male Children With Haemophilia A

guardian™ 3
Start date: June 2010
Phase: Phase 3
Study type: Interventional

This trial is conducted in Asia, Europe, and North and South America. The aim of this clinical trial is to investigate the safety and efficacy of turoctocog alfa (recombinant factor VIII, rFVIII (N8)) in male previously treated paediatric subjects with haemophilia A.

NCT ID: NCT01138163 Completed - Clinical trials for Non-small-cell Lung Cancer

Study of Bavituximab Plus Docetaxel in Patients With Locally Advanced or Metastatic Non-Squamous Non Small-Cell Lung Cancer

Start date: June 2010
Phase: Phase 2
Study type: Interventional

The primary purpose of this research study is to see whether adding bavituximab (an investigational drug) to the standard chemotherapy drug docetaxel, will improve the results of the treatment for non-small-cell lung cancer.

NCT ID: NCT01137682 Completed - Acromegaly Clinical Trials

Efficacy and Safety of Pasireotide Long Acting Release (LAR) Versus Octreotide LAR or Lanreotide Autogel (ATG) in Patients With Inadequately Controlled Acromegaly

PAOLA
Start date: July 19, 2010
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy and safety of pasireotide LAR 40 and 60 mg versus octreotide LAR or lanreotide ATG in patients with inadequately controlled acromegaly.

NCT ID: NCT01137526 Completed - Alzheimer's Disease Clinical Trials

Efficacy and Safety Study of ABT-384 in Subjects With Mild-to-Moderate Alzheimer's Disease

Start date: May 2010
Phase: Phase 2
Study type: Interventional

The purpose of this study is to test if the investigational medication, ABT-384, is a safe and effective treatment for adults with mild-to-moderate Alzheimer's Disease.

NCT ID: NCT01137474 Completed - Type 2 Diabetes Clinical Trials

A Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes and Inadequately Controlled Hypertension on an Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker

Start date: July 2010
Phase: Phase 3
Study type: Interventional

The purpose of this study is to learn whether dapagliflozin, after 12 weeks, can improve (decrease) blood pressure in patients with type 2 diabetes with uncontrolled hypertension who are on an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. The safety of this treatment will also be studied.

NCT ID: NCT01134185 Completed - Hepatic Impairment Clinical Trials

Evaluation of Prucalopride in Subjects With Moderate and Severe Hepatic Impairment

HI
Start date: May 2010
Phase: Phase 1
Study type: Interventional

This is a single centre, open-label phase I trial to investigate the effects of moderate to severe hepatic impairment on the pharmacokinetics of prucalopride in comparison with healthy volunteers. Furthermore the short-term safety and tolerability of a single dose of prucalopride will be assessed.