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NCT ID: NCT02471144 Completed - Clinical trials for Chronic Severe Plaque-type Psoriasis

Pediatric Study in Children and Adolescents With Severe Plaque Psoriasis

Start date: September 29, 2015
Phase: Phase 3
Study type: Interventional

This was a multicenter, randomized, double-blind, placebo- and active-controlled (etanercept in single blinded arm) study in pediatric subjects aged 6 years to less than 18 years with severe chronic plaque psoriasis. Approximately 160 subjects aged 6 years to <18 years were enrolled, of which at least 30 were 6 years to <12 years old. Subjects were enrolled at approximately 70 study sites worldwide.

NCT ID: NCT02468674 Completed - Sarcopenia Clinical Trials

A 24-week Off-drug Extension Study in Sarcopenic Elderly Who Completed Treatment in the 6-month Core Study

Start date: July 22, 2015
Phase: Phase 2
Study type: Interventional

This extension study was a 24-week off-drug follow-up of the core CBYM338E2202 (NCT ) study and the main objective was to determine the long-term durability of bimagrumab (BYM338) effect after a 6-month treatment period.

NCT ID: NCT02467907 Completed - Cervical Cancer Clinical Trials

Safety and Efficacy of Bevacizumab in Combination With Carboplatin and Paclitaxel for Metastatic, Recurrent or Persistent Cervical Cancer

Start date: July 28, 2015
Phase: Phase 2
Study type: Interventional

This study is to assess safety as defined by the frequency and severity of gastrointestinal (GI) perforation/fistula, GI-vaginal fistula and genitourinary (GU) fistula in participants treated with bevacizumab 15 milligrams per kilogram (mg/kg) in combination with paclitaxel and carboplatin, all repeated every 3 weeks, for recurrent, persistent or metastatic cervical cancer. In addition, this study will include evaluation of the overall safety profile of bevacizumab in combination with paclitaxel and carboplatin in this setting, assessment of GI perforation/fistula, GI-vaginal fistula and GU fistula events over time, and evaluation of efficacy.

NCT ID: NCT02465567 Completed - COPD Clinical Trials

Study to Assess the Efficacy and Safety of PT010 Relative to PT003 and PT009 in Subjects With Moderate to Very Severe COPD (Ethos)

Start date: June 30, 2015
Phase: Phase 3
Study type: Interventional

This is a randomized, double-blind, multi-center, parallel-group study to assess the efficacy and safety of PT010 relative to PT003 and PT009 on COPD exacerbations subjects with moderate to very severe COPD.

NCT ID: NCT02465515 Completed - Diabetes Mellitus Clinical Trials

Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus

Start date: July 1, 2015
Phase: Phase 4
Study type: Interventional

Albiglutide is an analogue of glucagon-like peptide-1 (GLP-1), used to treat type 2 diabetes This study will test whether albiglutide affects the occurrence of major cardiovascular events such as heart attacks or strokes and other important medical outcomes in persons with type 2 diabetes, when used alone or added to other diabetes treatments.

NCT ID: NCT02464969 Completed - Clinical trials for Venous Thromboembolism

Apixaban for the Acute Treatment of Venous Thromboembolism in Children

Start date: November 22, 2015
Phase: Phase 4
Study type: Interventional

To assess the safety and descriptive efficacy of apixaban in pediatric subjects requiring anticoagulation for the treatment of a VTE.

NCT ID: NCT02463123 Completed - Intensive Care Clinical Trials

Energy Expenditure Estimation in Cardiac Surgery

Start date: May 2015
Phase: N/A
Study type: Observational

Estimation of energy requirements is essential for adequate nutritional support in ICU. Indirect calorimetry being the golden standard of resting energy expenditure estimation is not available in most intensive care units. Different predictive equations have been developed, but not evaluated in cardiac population and have low accuracy in compare to the indirect calorimetry. The aim of present study is to develop cardio-specific equation for resting energy expenditure estimation.

NCT ID: NCT02462486 Completed - Clinical trials for Macular Degeneration

Safety and Efficacy of Abicipar Pegol in Participants With Neovascular Age-related Macular Degeneration

Start date: June 25, 2015
Phase: Phase 3
Study type: Interventional

This is a safety and efficacy study of abicipar pegol in participants with neovascular age-related macular degeneration.

NCT ID: NCT02461589 Completed - Clinical trials for Diabetes Mellitus, Type 2

Dose-finding of Semaglutide Administered Subcutaneously Once Daily Versus Placebo and Liraglutide in Subjects With Type 2 Diabetes

Start date: September 21, 2015
Phase: Phase 2
Study type: Interventional

This trial is conducted globally. The aim of this trial is to investigate dose-finding of semaglutide administered subcutaneously once daily versus placebo and liraglutide in subjects with type 2 diabetes

NCT ID: NCT02460978 Completed - Clinical trials for Type 1 Diabetes Mellitus

Dapagliflozin Evaluation in Patients With Inadequately Controlled Type 1 Diabetes

DEPICT 2
Start date: July 8, 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine if adding dapagliflozin to insulin is a safe and effective therapy to improve glycemic control in patients with type 1 diabetes.