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NCT ID: NCT00668070 Completed - Clinical trials for Non-Alcoholic Steatohepatitis

A Proof-of-principle Study of Oral Treatment of Non-alcoholic Steatohepatitis With a Novel PDE4 Inhibitor ASP9831

ASTER
Start date: April 2008
Phase: Phase 2
Study type: Interventional

The aim of this study is to explore the effect of a new drug (ASP9831) in patients with non-alcoholic steatohepatitis (NASH) by assessing clinical signs, laboratory data and biomarkers during a 12 week treatment period

NCT ID: NCT00667823 Completed - Clinical trials for Pulmonary Arterial Hypertension

Clinical Study to Assess the Long-term Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulmonary Arterial Hypertension

SERAPHIN OL
Start date: October 17, 2008
Phase: Phase 3
Study type: Interventional

The main objective of the AC 055 303/SERAPHIN OL study, which will follow the AC 055 302/SERAPHIN study, will be to assess the long-term safety and tolerability of ACT 064992 in patients with symptomatic PAH.

NCT ID: NCT00666718 Completed - Clinical trials for Diabetes Mellitus, Type 2

A Comparison Study of Basal Bolus Therapies Together With Lispro Insulin in Type 2 Diabetes Patients

Start date: April 2008
Phase: Phase 3
Study type: Interventional

This study is designed to look at if a basal bolus regimen of insulin lispro protamine suspension (ILPS) provides the same glycemic control as a basal bolus regimen of insulin glargine (when one basal bolus regimen is injected once daily together with insulin lispro injected 2-3 times daily).

NCT ID: NCT00665925 Completed - Clinical trials for Rheumatoid Arthritis

Efficacy and Safety Study of R935788 Tablets to Treat Rheumatoid Arthritis

Taski-2
Start date: May 2008
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether the Spleen Tyrosine Kinase (Syk) inhibitor, R935788 (R788), at a dose of 100 mg, orally, twice-a-day, and/or a dose of of 150 mg, orally, once-a-day is effective in the treatment of Rheumatoid Arthrits in patients who have had an inadequate clinical response to methotrexate.

NCT ID: NCT00665847 Completed - HIV-1 Clinical Trials

TMC125-TiDP35-C213: Safety and Antiviral Activity of Etravirine (TMC125) in Treatment-Experienced, HIV Infected Children and Adolescents

Start date: November 2008
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the safety and antiviral activity of etravirine in treatment-experienced human immunodeficiency virus (HIV) infected children and adolescents.

NCT ID: NCT00665366 Completed - Clinical trials for Bipolar Disorder Mania

Study to Evaluate the Efficacy and Safety of Aripiprazole Administered With Lithium or Valproate Over 12 Weeks in the Treatment of Mania in Bipolar I Disorder

Start date: June 2008
Phase: Phase 3
Study type: Interventional

The purpose of the study is to determine whether aripiprazole provides additional clinical benefit to patients with Bipolar I disorder when combined with lithium or valproate over 12 weeks.

NCT ID: NCT00664716 Completed - Clinical trials for Rheumatoid Arthritis

Assessment Of The Safety And Efficacy Of BG9924 In Rheumatoid Arthritis (RA) Participants

RESPOND
Start date: July 2007
Phase: Phase 2
Study type: Interventional

Safety and efficacy of BG9924 in RA participants that have had an inadequate response to disease-modifying anti-rheumatic drug (DMARD) therapy.

NCT ID: NCT00664573 Terminated - Clinical trials for Rheumatoid Arthritis

104RA204 Assessment of the Safety and Efficacy of BG9924 in Rheumatoid Arthritis (RA) Participants

RESPOND-EXT
Start date: November 2007
Phase: Phase 2
Study type: Interventional

To observe the long-term treatment with BG9924 when administered to participants with RA who previously participated in a Biogen Idec Study.

NCT ID: NCT00664534 Completed - Clinical trials for Diabetes Mellitus, Type 2

Pre-Mix Insulin Lispro Treatment for Type 2 Diabetes Patients Who Consume a Light Breakfast

Start date: April 2008
Phase: Phase 4
Study type: Interventional

This study is designed to look at how best to start and then gradually intensify (as needed) the insulin lispro premix regimen in type 2 diabetes patients who consume a light breakfast.

NCT ID: NCT00663858 Completed - Clinical trials for Benign Prostatic Hypertrophy

Cetrorelix Pamoate in Patients With Symptomatic Benign Prostatic Hypertrophy (BPH)

Start date: March 2008
Phase: Phase 3
Study type: Interventional

Benign Prostatic Hypertrophy (BPH) is a common and bothersome condition of aging men. It is characterized by an enlargement of the prostate occurring in human male over the age of 50 which increases in prevalence with age, and among those aged 50 to 80, about 40% report moderate or severe urinary symptoms of prostatism. The aim of treatment is to improve patients' quality of life which primarily depends on the severity of the symptoms of BPH. Current treatments of BPH have a benefit / risk ratio which leaves room for improvement. For this study, study medication (Cetrorelix pamoate or placebo) is administered by injection in the buttocks (Intramuscular). All patients completing the double-blind portion (Week 0 to 52) are eligible to receive the active drug during the open-label part of the study (Week 52 to 90).