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NCT ID: NCT02455687 Recruiting - Bronchial Asthma Clinical Trials

Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose ,With/ Without the Nebulized Budesonide For the Management of the Severe Asthma Exacerbation in the Emergency Room; A Randomized Controlled Trial.

Start date: June 2015
Phase: Phase 3
Study type: Interventional

Many studies have investigated the efficacy and safety of Intravenous magnesium sulfate and inhaled steroids in addition to the standard treatment for patients with severe asthma attacks. In this 2x2 factorial design blinded randomized study, no interaction of hypothesized treatments is expected.Investigators hypothesize that two doses of intravenous magnesium sulfate,a high dose followed by a (lower) standard dose, will shorten the time to medical readiness for discharge compared to a single standard dose followed by placebo.The second hypothesis is that nebulized inhaled budesonide will be superior to placebo.

NCT ID: NCT02098980 Recruiting - Insulin Resistance Clinical Trials

Nutritional Intervention of Type II Diabetes Mellitus by Vitamin D in Qatar

Start date: May 2014
Phase: N/A
Study type: Interventional

There is an association between elevated Type II Diabetes Mellitus (T2DM) risk and low serum levels of vitamin D. It is important to examine whether Vitamin D can enhance oral glucose tolerance in individuals at risk for developing T2DM. As such, the hypothesis suggested is that Vitamin D supplementation (4,000 IU/day) for 24 weeks in pre-diabetic individuals will decrease insulin resistance and the associated metabolic indices linked to the later development of T2DM.

NCT ID: NCT01724268 Recruiting - Clinical trials for RHEUMATOID ARTHRITIS

Corticosteroids and Anti TNF in Methotrexate Inadequate Responder Rheumatoid Arthritis Patient

Start date: May 2012
Phase: Phase 3
Study type: Interventional

Compare the efficacy of adding small doses of prednisolone (10 mg) daily to the efficacy of adding one of the available anti TNF in the treatment of methotrexate inadequate responder rheumatoid arthritis patient. Hypothesis: Methotrexate + Prednisolone vs. Methotrexate + anti TNF

NCT ID: NCT01646619 Recruiting - Clinical trials for Severe Hypoxic Ischemic Encephalopathy

Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy

MagCool
Start date: May 2012
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess whether the addition of a drug such as Magnesium sulphate while providing therapeutic hypothermia (or cooling) to babies who are asphyxiated at birth provides additional benefit to the babies' survival and outcome compared to cooling alone.

NCT ID: NCT01584726 Recruiting - Asthma Clinical Trials

Nebulized Magnesium Sulfate in Children With Moderate to Severe Asthma

Start date: December 2012
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the use of magnesium sulfate nebulization in patient with moderate to severe asthma exacerbation in pediatric emergency.

NCT ID: NCT01558466 Recruiting - Clinical trials for Persistent Fetal Circulation Syndrome

Sildenofil in Persistent Pulmonary Hypertension in Newborns

Sildeno
Start date: November 2011
Phase: Phase 3
Study type: Interventional

This study hopes to evaluate the effectiveness of early combined use of Sildenafil and nitric oxide (iNO) in newborns with Persistent pulmonary hypertension (PPHN) and or hypoxemic respiratory failure and assess whether this would improve oxygenation, improve time on mechanical ventilation for these babies and also prevent rebound hypoxic episodes.