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NCT ID: NCT02939183 Completed - Clinical trials for Relapsed or Refractory Multiple Myeloma

Phase 1b Study Evaluating OPomD in Relapsed or Refractory Multiple Myeloma

INTREPID-1
Start date: January 17, 2017
Phase: Phase 1
Study type: Interventional

A study evaluating two new formulations of oprozomib plus pomalidomide and dexamethasone in patients with relapsed refractory multiple myeloma.

NCT ID: NCT02938286 Completed - Clinical trials for Local Anesthesia of the Skin

Fractional Laser Assisted Delivery of Anesthetics III

Start date: March 2016
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare the effect of pretreatment with two different ablative laser modalities, a CO2 laser and an Er:YAG laser, and to assess the role of laser density in fractional laser assisted topical anesthesia.

NCT ID: NCT02938273 Completed - Clinical trials for Carcinoma, Squamous Cell of Head and Neck

Bioimmunoradiotherapy (Cetuximab/RT/Avelumab)

Start date: February 1, 2017
Phase: Phase 1
Study type: Interventional

This is an open-label phase IB trial with Bioimmunoradiotherapy, i.e. concurrent radiotherapy with intravenous administration of cetuximab and avelumab followed by avelumab maintenance therapy in patients with locally advanced head and neck cancer, unfit for cisplatin.

NCT ID: NCT02937883 Completed - Dementia Clinical Trials

Empowerment Intervention for Persons With Young Onset Dementia

Start date: October 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effects of an empowerment intervention for community-dwelling persons with young onset dementia and their informal caregivers.

NCT ID: NCT02937454 Completed - Heart Failure Clinical Trials

Study to Compare Ferric Carboxymaltose With Placebo in Patients With Acute Heart Failure and Iron Deficiency

Affirm-AHF
Start date: April 3, 2017
Phase: Phase 4
Study type: Interventional

Study to Compare Ferric Carboxymaltose With Placebo in Patients With Acute Heart Failure and Iron Deficiency (Affirm-AHF)

NCT ID: NCT02936778 Completed - Clinical trials for Childhood Asthma With Status Asthmaticus

Status Asthmaticus on the Intensive Care Prospective - STATIC PRO

Start date: August 2016
Phase:
Study type: Observational

This study will prospectively assess the impact and relevance of several risk factors for children with severe acute asthma (SAA) or acute wheeze that have been identified in retrospective studies. Secondary we will assess short-term medical and psychosocial functioning in patient (and parents) admitted to a PICU for SAA/acute wheeze versus a control group admitted to a MC for SAA/acute wheeze.

NCT ID: NCT02936635 Completed - Clinical trials for Amyotrophic Lateral Sclerosis (ALS)

A Study for Patients Who Completed VITALITY-ALS (CY 4031)

VIGOR-ALS
Start date: October 17, 2016
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the long-term safety and tolerability of tirasemtiv in patients with ALS who had completed the double-blind placebo-controlled study of tirasemtiv in ALS (CY 4031).

NCT ID: NCT02935634 Completed - Clinical trials for Advanced Gastric Cancer

A Study to Test Combination Treatments in Participants With Advanced Gastric Cancer

FRACTION-GC
Start date: November 29, 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the preliminary efficacy, safety, and tolerability of Nivolumab in combination with Ipilimumab or other treatment therapies in participants with advanced gastric cancer.

NCT ID: NCT02935608 Completed - Clinical trials for Lumbosacral Radiculopathy

Study to Evaluate the Efficacy and Safety of BIIB074 in Neuropathic Pain From Lumbosacral Radiculopathy

RELAY-1
Start date: October 31, 2016
Phase: Phase 2
Study type: Interventional

The primary objective of the study is to evaluate the efficacy of two dose regimens of BIIB074 on neuropathic pain in participants with pain from lumbosacral radiculopathy (PLSR). Secondary objectives are to evaluate the efficacy of 2 dose regimens of BIIB074 on additional neuropathic pain measures and assessments of low back pain, disability, and quality of life; To investigate the safety and tolerability of 2 dose regimens of BIIB074 and To characterize the pharmacokinetics (PK) of BIIB074 in this population.

NCT ID: NCT02935244 Completed - Clinical trials for Surgical Wound Infection

Advanced Understanding of Staphylococcus Aureus Infections in Europe - Surgical Site Infections

ASPIRE-SSI
Start date: December 2016
Phase:
Study type: Observational

ASPIRE-SSI is a prospective, observational, multicentre cohort study among adult surgical patients, which aims to determine the incidence of healthcare-associated S. aureus infections, particularly S. aureus surgical site infections (SSIs), across Europe and to assess the most important risk factors for this type of infection.