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NCT ID: NCT00886392 Completed - Diabetes Mellitus Clinical Trials

Diabetic Macular Edema Severity at Diagnosis

Start date: June 2006
Phase: N/A
Study type: Observational

The purpose of this study is to identify the severity level distribution at the moment of diagnosis, in diabetic patients with macular edema from a Mexico City sample, and to identify the rate with severe macular edema that needed immediate treatment.

NCT ID: NCT00886028 Active, not recruiting - Clinical trials for Malignant Pleural Mesothelioma

Palliative Treatment With Liposomal Doxorubicin Plus Cisplatin for Patients With Malignant Pleural Mesothelioma

Start date: September 2006
Phase: Phase 2
Study type: Interventional

Liposomal doxorubicin consists on doxorubicin encapsulated in liposomes that are composed of phosphatidylcholine and cholesterol. Liposomal doxorubicin can extravasate into tumors with abnormal vascular endothelium but may not penetrate normal tissues lowering its toxicity and increasing its efficiency. Combining Liposomal doxorubicin with cisplatin could be an effective new chemotherapy treatment for malignant pleural mesothelioma . Hypothesis: Liposomal doxorubicin combined with cisplatin could increase response rates to chemotherapy, progression free survival and overall survival in patients with malignant pleural mesothelioma.

NCT ID: NCT00884507 Completed - Alzheimer's Disease Clinical Trials

A Study of RO5313534 as Add-on to Donepezil Treatment in Patients With Mild to Moderate Alzheimer's Disease

Start date: May 2009
Phase: Phase 2
Study type: Interventional

This 4 arm study will assess the efficacy and safety of RO5313534 (MEM3454) versus placebo added to donepezil, in patients with mild to moderate Alzheimer's disease. Following a screening period, patients will be randomized to one of 4 treatments (placebo, or RO5313534 1mg, 5mg or 15mg po daily) with background therapy of donepezil (5mg or 10mg).The anticipated time on study treatment is 6 months, and the target sample size is 100-500 individuals.

NCT ID: NCT00883896 Completed - Clinical trials for Rheumatoid Arthritis

Study To Evaluate The Safety And Efficacy Of ILV-094 In Subjects With Rheumatoid Arthritis

Start date: June 18, 2009
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to assess the safety and efficacy of different dose regimens of ILV-094 compared with placebo, administered subcutaneously to subjects with active rheumatoid arthritis who are taking methotrexate.

NCT ID: NCT00883493 Completed - Clinical trials for Acute Bipolar Depression

Efficacy and Safety of Quetiapine Versus Quetiapine Plus Lithium in Bipolar Depression

QUALITY
Start date: April 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the efficacy of quetiapine fumarate monotherapy with quetiapine fumarate in combination with lithium in the treatment of a major depressive episode in patients with bipolar disorder.

NCT ID: NCT00883116 Terminated - Endometrial Cancer Clinical Trials

A Study of Ixabepilone as Second-line Therapy for Locally Advanced, Recurrent, or Metastatic Endometrial Cancer

IXAMPLE2
Start date: August 2009
Phase: Phase 3
Study type: Interventional

The primary purpose of this study is to investigate whether administration of ixabepilone results in superior outcome as assessed by overall survival compared with that achieved with standard chemotherapy (paclitaxel or doxorubicin) in women with advanced endometrial cancer that has progressed following first-line chemotherapy.

NCT ID: NCT00882453 Completed - Multiple Sclerosis Clinical Trials

Physical Activity and Fatigue in Early Multiple Sclerosis (MS)

BEGIN
Start date: August 2006
Phase: N/A
Study type: Observational

The purpose of this observational study is to obtain a survey on physical activity in patients who for the first time have experienced symptoms which indicate a high risk for developing multiple sclerosis (MS) and in patients with recently diagnosed MS, and to obtain information on factors potentially influencing the patients' level of activity.

NCT ID: NCT00882024 Completed - Clinical trials for Active Rheumatoid Arthritis

Safety and Efficacy Study of Tranilast in Patients With Active Rheumatoid Arthritis (RA)

Start date: March 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate whether tranilast at two different dosages compared to placebo is effective in patients with active RA when added to continuing methotrexate (MTX) therapy.

NCT ID: NCT00879970 Terminated - Clinical trials for Diabetes Mellitus, Type 2

Thiazolidinedione Intervention With Vitamin D Evaluation

TIDE
Start date: May 2009
Phase: Phase 4
Study type: Interventional

This study will answer two separate questions. The first question is to test the cardiovascular effects of long-term treatment with rosiglitazone or pioglitazone when used as part of standard of care compared to similar standard of care without rosiglitazone or pioglitazone in patients with type 2 diabetes who have a history of or are at risk for cardiovascular disease. The second question will compare the effects of long-term supplementation of vitamin D on death and cancer

NCT ID: NCT00879333 Completed - Clinical trials for Advanced Gastric Cancer

Safety and Efficacy of RAD001 (Everolimus) Monotherapy Plus Best Supportive Care in Patients With Advanced Gastric Cancer (AGC)

GRANITE-1
Start date: July 2009
Phase: Phase 3
Study type: Interventional

This study is designed to assess the safety and efficacy of RAD001 monotherapy in patients with advanced gastric cancer which has progressed after one or two lines of prior chemotherapy.