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NCT ID: NCT01739400 Terminated - Clinical trials for Pulmonary Arterial Hypertension

Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger Syndrome

MAESTRO-OL
Start date: September 10, 2013
Phase: Phase 3
Study type: Interventional

Long-term study to evaluate if macitentan is safe, tolerable and efficient enough to be used for treatment of Eisenmenger syndrome.

NCT ID: NCT01737957 Terminated - Clinical trials for Proliferative Diabetic Retinopathy

Safety and Efficacy of Low-Fluence PRP for PDR

Start date: November 2012
Phase: N/A
Study type: Interventional

To determine the safety and efficacy of a single session of low-fluence panretinal photocoagulation when compared to full-fluence PRP. Hypothesis: a single-session of low-fluence PRP will be safe regarding the progression of macular edema and the presence of adverse events, and will efficiently induce regression of neovascularization.

NCT ID: NCT01737853 Completed - Clinical trials for Glaucoma Primary Open Angle

Comparison of Efficacy & Tolerability Between Ganfort vs Krytantek in Mexican Patients With Primary Open-Angle Glaucoma (POAG) or Ocular Hypertension (OHT)

Start date: February 2011
Phase: N/A
Study type: Observational

The objective of this phase IV clinical multi-center trial will be to compare the efficacy and safety of Ganforti® versus Krytantek®, using a cross-over design during a six month period (including a one-month wash-in period) in POAG and OH patients.

NCT ID: NCT01737541 Terminated - Clinical trials for Intracerebral Hemorrhage

Fluoxetine for Motor Recovery After Acute Intracerebral Hemorrhage

FMRICH
Start date: November 2012
Phase: Phase 3
Study type: Interventional

This is a randomized, double-blind, placebo-controlled, multicenter clinical trial that will be carried out in Mexico. The purpose of this study is to test whether a 3-month treatment with fluoxetine enhances motor recovery in non-depressed patients with acute intracerebral hemorrhage.

NCT ID: NCT01735175 Completed - Clinical trials for Neutropenic Complications

Phase III Study Comparing the Efficacy and Safety of LA-EP2006 and Neulasta®

PROTECT-1
Start date: June 2012
Phase: Phase 3
Study type: Interventional

The study will assess the efficacy of LA-EP2006 compared to Peg-Filgrastim with respect to the mean duration of severe neutropenia during treatment with myelosuppressive chemotherapy in breast cancer patients.

NCT ID: NCT01734382 Completed - Clinical trials for Juvenile Idiopathic Arthritis

A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab)

Start date: June 10, 2013
Phase: Phase 4
Study type: Interventional

PART1 Participants in Part 1 (Run-in-Phase) of study will receive tocilizumab (TCZ) (RoActemra/Actemra) 12 milligrams per kilogram (mg/kg) or 8 mg/kg intravenously (IV) every 2 weeks (Q2W) for up to 24 weeks. Participants who experience a laboratory abnormality during Part 1 may be eligible to move into Part 2 of the study. PART 2 This open-label Phase IV study will evaluate the efficacy, safety, pharmacokinetics, pharmacodynamics and immunogenicity of tocilizumab in reduced dose frequency in participants with adequately controlled systemic juvenile idiopathic arthritis who have experienced a laboratory abnormality on twice weekly tocilizumab dosing, that has since resolved. Participants will receive tocilizumab 12 mg/kg or 8 mg/kg intravenously every 3 weeks. After 5 consecutive infusions, participants who experience an event of neutropenia, thrombocytopenia or liver enzyme abnormality will move to every 4 weeks tocilizumab administration. Anticipated time on study treatment is 52 weeks.

NCT ID: NCT01733329 Completed - Clinical trials for Postpartum Hemorrhage

Buccal Misoprostol During Cesarean Section for Preventing Postpartum Hemorrhage

Start date: February 2008
Phase: Phase 4
Study type: Interventional

Objective: to demonstrate that buccal misoprostol administration during cesarean delivery in women with risk factors for uterine atony decreases the need for additional uterotonic medications, uterine atony and postpartum hemorrhage. Design: randomized, double-blinded, placebo-controlled trial.

NCT ID: NCT01732822 Completed - Clinical trials for Peripheral Artery Disease

A Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease

EUCLID
Start date: December 4, 2012
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the effects of ticagrelor and clopidogrel in patients with Peripheral Artery Disease.

NCT ID: NCT01730534 Completed - Clinical trials for Diabetes Mellitus, Non-Insulin-Dependent

Multicenter Trial to Evaluate the Effect of Dapagliflozin on the Incidence of Cardiovascular Events

DECLARE-TIMI58
Start date: April 25, 2013
Phase: Phase 3
Study type: Interventional

This study is being carried out to determine the effect of dapagliflozin on cardiovacular outcomes when added to current background therapy in patients with type 2 diabetes with either established cardiovacular disease or cardiovascular risk factors.

NCT ID: NCT01730053 Completed - Clinical trials for Hypercholesterolemia

Study of Alirocumab (REGN727/SAR236553) added-on to Rosuvastatin Versus Other Lipid Modifying Treatments (LMT) (ODYSSEY OPTIONS II)

Start date: November 30, 2012
Phase: Phase 3
Study type: Interventional

To evaluate the reduction of low-density lipoprotein cholesterol (LDL-C) by alirocumab (REGN727/SAR236553) as an add-on therapy to other LMT in patients with hypercholesterolemia at high cardiovascular (CV) risk.