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NCT ID: NCT00300794 Completed - Opiate Dependence Clinical Trials

Effects of Ketamine On Precipitated Opioid Withdrawal Under General Anaesthesia

Start date: February 2003
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine whether low-dose ketamine infusion is effective in suppressing the symptoms of opiate withdrawal during rapid opiate antagonist induction (RAI).

NCT ID: NCT00300378 Completed - Clinical trials for Depressive Disorder, Major

Study Evaluating the Efficacy and Safety of Desvenlafaxine Tablets in Adult Outpatients With Major Depressive Disorder

Start date: March 2006
Phase: Phase 3
Study type: Interventional

The primary objective is to compare the antidepressant efficacy, safety, and tolerability of DVS SR versus placebo in subjects with Major Depressive Disorder. Additional objectives include testing both general and functional quality-of-life outcomes and satisfaction with therapy reported by the subject.

NCT ID: NCT00293124 Completed - Clinical trials for Gastrointestinal Stromal Tumors

Open-label Trial of GlivecWith Unresectable or Metastatic Malignant Gastrointestinal Stromal Tumors

Start date: March 2004
Phase: Phase 3
Study type: Interventional

The rationale is to assess the clinical and biological activity of Imatinib and to compare the data with historic data. Additionally this study has been designed to gain more experience with the treatment of GIST in several Central and Eastern European Countries.

NCT ID: NCT00290355 Completed - Clinical trials for Lung Cancer, Non-Small Cell

Study to Test the Efficacy of the Vaccine GSK 249553 in Treating Non-small-cell Lung Cancer After Tumour Removal by Surgery

Start date: May 28, 2002
Phase: Phase 2
Study type: Interventional

Patients will receive injections of GSK 249553 vaccine . Appropriate tests will be performed to assess the safety of the treatment and its ability to induce an immune response.

NCT ID: NCT00289978 Completed - Clinical trials for Relapsing-remitting Multiple Sclerosis

Efficacy and Safety of Fingolimod in Patients With Relapsing-remitting Multiple Sclerosis

FREEDOMS
Start date: January 2006
Phase: Phase 3
Study type: Interventional

This study assessed the efficacy, safety, and tolerability of 2 doses of oral fingolimod (1.25 mg/day and 0.5 mg/day) compared to placebo in patients with relapsing-remitting multiple sclerosis (RRMS)

NCT ID: NCT00289198 Completed - Clinical trials for Rhinitis, Allergic, Perennial

Once-Daily Investigational Nasal Spray In Adults And Adolescents With Perennial Allergic Rhinitis (PAR)

Start date: February 7, 2006
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to compare the efficacy and safety of GW685698X 100mcg once daily (QD) aqueous nasal spray with vehicle placebo nasal spray in adult and adolescent subjects (12 years of age and older) with perennial allergic rhinitis (PAR).

NCT ID: NCT00286897 Completed - Parkinson's Disease Clinical Trials

The Efficacy, Safety and Tolerability of E2007 in Levodopa Treated Parkinson's Disease Patients With Motor Fluctuations

Start date: February 2006
Phase: Phase 3
Study type: Interventional

Patients will be randomised to receive either placebo or the study drug for a period of 30 weeks, in addition to their standard Parkinsonian medications. During the first 8 weeks, the patient's levodopa doses may be adjusted if necessary by the investigator. For the remainder of the 22 weeks, all medications should be kept stable. Patients will be required to attend the clinic twice during the screening period and then a further 8 times during the treatment period. They will be required to complete home diaries where they will record their motor function. In addition, their doctor will assess their Parkinson's disease during the clinic visits. There will also be blood draws for safety and pharmacokinetic and pharmacogenomics evaluation. Following the treatment and assessment period, they will return to the clinic one month later for follow up.

NCT ID: NCT00280059 Completed - Epilepsy, Partial Clinical Trials

Study Of The Safety And Efficacy Of Lyrica In The Treatment Of Newly Diagnosed Partial Epilepsy

Start date: August 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess whether Lyrica is a safe and effective treatment for partial epilepsy in comparison with an established treatment, Lamictal.

NCT ID: NCT00268216 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Survival Of Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Start date: September 2000
Phase: Phase 3
Study type: Interventional

The purpose of this study is to see if fluticasone 500mcg/salmeterol 50mcg can improve the survival of subjects with COPD and also assess the long term safety profile of this drug.

NCT ID: NCT00268177 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Airway Inflammation In Patients With Chronic Obstructive Pulmonary Disease

Start date: October 2002
Phase: Phase 3
Study type: Interventional

This study was designed to look at effects of salmeterol/fluticasone propionate compared to placebo on airway inflammation in patients with chronic obstructive airways disease