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NCT ID: NCT03702777 Completed - Underactive Bladder Clinical Trials

A Study of ASP8302 in Participants With Underactive Bladder

Start date: November 20, 2018
Phase: Phase 2
Study type: Interventional

The study objectives of this study are to evaluate the efficacy of ASP8302 compared with placebo in participants with underactive bladder (UAB), to investigate the safety and tolerability of ASP8302 compared with placebo in participants with UAB, to investigate the pharmacokinetics of ASP8302 in participants with UAB and to support the development of the UAB - Patient Reported Outcome (PRO).

NCT ID: NCT03702413 Completed - Clinical trials for Mechanical Thrombectomy

Randomized Controlled Trial of Endovascular Therapy for Acute Large Vessel Occlusion With Large Ischemic Core

Start date: November 30, 2018
Phase: N/A
Study type: Interventional

RESCUE-Japan LIMIT(Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism Japan Large IscheMIc core Trial) is a prospective, open label, blinded endpoint (PROBE), Japanese, two-arm, randomized, controlled, post-market study to compare the effectiveness of endovascular treatment as compared to best medical treatment alone in the acute ischemic stroke patients with an low ASPECTS (CT-ASPECTS 3-5 or DWI-ASPECTS 3-5). The purpose of this study is to investigate the efficacy of endovascular treatment for acute large vessel occlusion with large ischemic core (CT-ASPECT score 3-5 or DWI-ASPECT score 3-5).

NCT ID: NCT03697603 Completed - Clinical trials for Major Depressive Disorder

A Study of Brexpiprazole in Patients With Major Depressive Disorder

Start date: July 30, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this 14 week, randomized, double-blind, placebo controlled study is to assess the safety and efficacy of brexipiprazole to placebo as adjunctive treatment to an assigned open-label marketed antidepressant therapy (ADT) in patients with Major Depressive Disorder.

NCT ID: NCT03696771 Completed - Clinical trials for NON-breast HER2+ Malignancies

Study to Determine Safety and Dose of NJH395 in Non-breast HER2+ Advanced Cancer

Start date: December 27, 2018
Phase: Phase 1
Study type: Interventional

A first-in-human study using NJH395 in non-breast HER2-positive advanced malignancies

NCT ID: NCT03696108 Completed - Chronic Cough Clinical Trials

A Study of Gefapixant (MK-7264) in Japanese Adult Participants With Refractory or Unexplained Chronic Cough (MK-7264-038)

Start date: October 31, 2018
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to evaluate the safety of two doses of gefapixant (MK-7264) in Japanese adult participants with refractory or unexplained chronic cough.

NCT ID: NCT03694522 Completed - Gastric Cancer Clinical Trials

A Study of Bemarituzumab (FPA144) Combined With Modified FOLFOX6 (mFOLFOX6) in Gastric/Gastroesophageal Junction Cancer

FIGHT
Start date: September 14, 2018
Phase: Phase 2
Study type: Interventional

The main objective of the Phase 2 part of the study is to evaluate the efficacy of bemarituzumab (FPA144), a targeted antibody, in combination with modified FOLFOX6 compared to placebo in combination with modified FOLFOX6 in participants with advanced gastrointestinal cancer.

NCT ID: NCT03693170 Completed - Clinical trials for BRAF V600E-mutant Metastatic Colorectal Cancer

Encorafenib, Binimetinib and Cetuximab in Subjects With Previously Untreated BRAF-mutant ColoRectal Cancer

ANCHOR-CRC
Start date: January 17, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of the combination of study drugs encorafenib, binimetinib and cetuximab in patients who have BRAF V600 mutant metastatic colorectal cancer and have not received any prior treatment for their metastatic disease.

NCT ID: NCT03693131 Completed - Clinical trials for Hypertriglyceridemia

Efficacy of MND-2119 in Participants With Hypertriglyceridemia

Start date: October 27, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of MND-2119 compared to EPADEL CAPSULES 300 in participants with hypertriglyceridemia.

NCT ID: NCT03690713 Completed - Stable Angina Clinical Trials

International Collaboration of Comprehensive Physiologic Assessment

Start date: June 1, 2018
Phase:
Study type: Observational

The current study evaluated prognostic implication of comprehensive physiologic assessment using fractional flow reserve, coronary flow reserve (CFR) and index of microcirculatory resistance (IMR).

NCT ID: NCT03689153 Completed - Healthy Clinical Trials

A Study of JNJ-63733657 in Healthy Japanese Participants

Start date: September 28, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety and tolerability of JNJ-63733657 following single ascending intravenous (IV) dose administration in healthy Japanese participants.