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NCT ID: NCT04798586 Active, not recruiting - Clinical trials for Relapsed or Refractory Multiple Myeloma

MAGNETISMM-2: Study of Elranatamab (PF-06863135) in Japanese Participants With Multiple Myeloma

Start date: March 22, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to confirm the safety and tolerability of elranatamab (PF-06863135) in Japanese participants with relapsed or refractory MM.

NCT ID: NCT04797000 Recruiting - Clinical trials for Myelodysplastic Syndromes

Study of Efficacy and Safety of Eltrombopag in Lower-risk MDS Patients With Platelet Transfusion Dependence

Start date: May 25, 2021
Phase: Phase 2
Study type: Interventional

This study is designed to evaluate the efficacy and safety of eltrombopag monotherapy in Japanese adult patients with platelet transfusion-dependent lower-risk Myelodysplastic syndromes (LR-MDS).

NCT ID: NCT04796350 Recruiting - Osteoporosis Clinical Trials

RESTORE - Study of AGN1 LOEP to Prevent Secondary Hip Fractures

Start date: April 24, 2021
Phase: N/A
Study type: Interventional

A randomized controlled trial to evaluate AGN1 to prevent secondary hip fractures in osteoporotic women undergoing treatment of index hip fractures. Up to 2400 subjects will be randomized between a treatment group and a control group. Subjects will be followed for a minimum of 5 years after undergoing hip fracture repair surgery.

NCT ID: NCT04795245 Completed - Clinical trials for Non-squamous, Non-Small Cell Lung Cancer

Non-interventional Study for Real-world Data of Afatinib Treatment in First-line Setting and of Subsequent Therapies for Patients With Advanced Epidermal Growth Factor Receptor (EGFR) Mutation-positive Lung Adenocarcinoma

Start date: August 26, 2021
Phase:
Study type: Observational

The primary objective is to confirm Time on Treatment (TOT) related to afatinib treatment as first-line therapy in patients with Epidermal Growth Factor Receptor (EGFR) mutation-positive Non-Small Cell Lung Cancer (NSCLC). The observation in the real-world setting of the time from the start of the first-line afatinib until the end of subsequent treatment in this study will provide insights on the sequence of treatment for patients. The Japanese healthcare system will enable this study to evaluate multiple treatment options after afatinib treatment.

NCT ID: NCT04791332 Completed - Healthy Clinical Trials

A Study of JNJ-67953964 in Healthy Japanese Adult Male Participants

Start date: April 30, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) after single- and multiple-dose oral administration of JNJ-67953964 in healthy Japanese adult male participants.

NCT ID: NCT04791319 Terminated - Dermatitis, Atopic Clinical Trials

A Study of Bermekimab (JNJ-77474462) in the Treatment of Participants With Moderate to Severe Atopic Dermatitis

GENESIS
Start date: May 3, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of bermekimab in participants with moderate to severe atopic dermatitis (AD).

NCT ID: NCT04790175 Recruiting - Clinical trials for Antidiuretic Hormone, Inappropriate Secretion

Samsca Post-marketing General Drug Use-results Survey in Patients With Hyponatremia in SIADH

Start date: March 29, 2021
Phase:
Study type: Observational

The purpose of this study is to confirm the safety of tolvaptan in patients with hyponatremia in syndrome of inappropriate antidiuretic hormone secretion (SIADH) in Japan

NCT ID: NCT04789317 Recruiting - Clinical trials for Non ST Elevation Myocardial Infarction

Pullback Pressure Gradient (PPG) Global Registry

PPG Global
Start date: December 23, 2020
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to determine the predictive capacity of the Pullback Pressure Gradient (PPG) index for post-PCI FFR and to determine the impact of the PPG index on clinical decision making about revascularization and on clinical outcomes.

NCT ID: NCT04784780 Recruiting - Clinical trials for Chronic Constipation

Long-term Elobixibat for Chronic Constipation

TANK-27
Start date: August 6, 2021
Phase: Phase 4
Study type: Interventional

In this double-blind comparative study, AJG533 (elobixibat) 10 mg or AJG533 placebo was orally administered once daily before meals for 12 weeks in patients with chronic constipation, and the primary endpoint was the change from Week 2 of the observation period in the number of complete spontaneous bowel movements (CSBM) at Week 12 of the treatment period. The primary endpoint was the change in the number of complete spontaneous bowel movements (CSBM) from Week 2 of the observation period.

NCT ID: NCT04784715 Active, not recruiting - Clinical trials for Breast Cancer; HER2-positive; Metastatic

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

Start date: April 26, 2021
Phase: Phase 3
Study type: Interventional

The study will evaluate the efficacy and safety of trastuzumab deruxtecan (also known as T-DXd, DS-8201a), either alone or in combination with pertuzumab, in treating patients with Human epidermal growth factor receptor 2 (HER2)-positive breast cancer as a first line of treatment in the metastatic setting.