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NCT ID: NCT05252702 Active, not recruiting - Bradycardia Clinical Trials

Aveir DR i2i Study

Start date: February 2, 2022
Phase: N/A
Study type: Interventional

Prospective, non-randomized, multi-center, international study designed to evaluate the safety and effectiveness of the Aveirâ„¢ Dual-Chamber (DR) Leadless Pacemaker system.

NCT ID: NCT05252637 Completed - Clinical trials for Pelvic Organ Prolapse

Laparoscopic Fascial Duplication Plus Sacral Colpopexy in Posterior Vaginal Prolapse

Start date: November 1, 2019
Phase: N/A
Study type: Interventional

A Randomized Clinical Trial on Laparoscopic Fascial posterior vaginal duplication with absorbable sutures plus sacral colpopexy mesh placement VS sacral colpopexy isolated for vaginal posterior prolapse

NCT ID: NCT05252416 Recruiting - Ovarian Cancer Clinical Trials

(VELA) Study of BLU-222 in Advanced Solid Tumors

Start date: April 7, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anticancer activity of BLU-222, a selective inhibitor of CDK2.

NCT ID: NCT05252403 Recruiting - Clinical trials for Acute Lymphoblastic Leukemia

Residual Disease Driven Strategy for CARCIK (CD19) in Adults/Pediatric BCP-ALL

Start date: December 1, 2021
Phase: Phase 2
Study type: Interventional

This is a single arm, open-label, multi-center, phase II study to determine the activity and the safety of a therapeutic strategy that allows a second CARCIK-CD19 cells infusion, driven by the status of disease from one month after the first infusion, in adult and pediatric patients with r/r BCP- ALL.

NCT ID: NCT05251909 Completed - Clinical trials for Eosinophilic Gastroenteritis

Efficacy and Safety of Benralizumab in Patients With Eosinophilic Gastritis and/or Gastroenteritis (The HUDSON GI Study)

HUDSON GI
Start date: January 18, 2022
Phase: Phase 3
Study type: Interventional

This is a 3-part study. Part A is randomized, double-blinded, placebo-controlled and includes patients with eosinophilic gastritis and/or duodenal-only disease. After completing Part A, participants can continue to Part C - open-label benralizumab treatment period. Following the decision to close enrollment, patients in both Part A and Part C will be given the option to proceed to 6-months of open-label benralizumab treatment in Part D.

NCT ID: NCT05251285 Terminated - Clinical trials for Prophylactic Nipple Sparing Mastectomy (NSM)

Post Market Clinical Follow-up Study on da Vinci® Robotic-assisted Prophylactic Nipple Sparing Mastectomy With Breast Reconstruction

PREVENT
Start date: January 18, 2022
Phase:
Study type: Observational

The objective of this study is to collect post-market clinical safety and performance data on the robotic assisted prophylactic Nipple Sparing Mastectomy (R-NSM) surgery performed with the da Vinci Xi/X Surgical System as part of a PMCF Plan.

NCT ID: NCT05251259 Recruiting - Asthma Clinical Trials

Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-Severe Uncontrolled Asthma

FLASH
Start date: January 27, 2022
Phase: Phase 2
Study type: Interventional

This is a randomised, placebo-controlled, double-blind study to assess the efficacy and safety of Atuliflapon administered once daily over a 12-week treatment period to adult participants with moderate to severe uncontrolled asthma.

NCT ID: NCT05250973 Recruiting - Amyloidosis Clinical Trials

A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis

AQUARIUS
Start date: March 1, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to characterize cardiac safety of Daratumumab, Cyclophosphamide, Bortezomib, and Dexamethasone (D-VCd) treatment regimens (Arm A: daratumumab + immediate VCd treatment and Arm B: daratumumab + deferred VCd) in newly diagnosed systemic amyloid light chain (AL) amyloidosis with cardiac involvement and to identify potential mitigation strategies for cardiac toxicity (cohort 1); to characterize the pharmacokinetics of subcutaneous (SC) daratumumab, among racial and ethnic minorities, including Black or African American, with newly diagnosed AL amyloidosis treated with D-VCd (cohort 2).

NCT ID: NCT05250934 Completed - Stroke Clinical Trials

Robotic Telerehabilitation of the Upper Limb in Stroke

TELEREHAB
Start date: May 12, 2021
Phase: N/A
Study type: Interventional

The goal of the study is to investigate the feasibility and the effects of a home-based upper-limb rehabilitation treatment (based on teleconsulting, telemonitoring, and robotic telerehabilitation using the robot Icone and integrated sensors) in patients with stroke.

NCT ID: NCT05250596 Recruiting - Clinical trials for Non ST Segment Elevation Acute Coronary Syndrome

COLchicine On-admission to Reduce Inflammation in Acute Coronary Syndrome (COLOR-ACS)

COLOR-ACS
Start date: February 24, 2022
Phase: Phase 2
Study type: Interventional

Since colchicine is known to have anti-inflammatory effects and inflammation is an early component of acute coronary syndrome (ACS), this study aims to evaluate the acute effects of low-dose colchicine, in addition to atorvastatin, administered on-admission to statin-naive patients with non-ST elevation ACS scheduled for early invasive strategy.