There are about 9745 clinical studies being (or have been) conducted in Israel. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
This study will evaluate the antitumor activity and safety of RAD001 in patients with Plexiform neurofibromas (PN) associated with Neurofibromatosis Type 1 (NF1). The aim of the study is to : 1. determine whether RAD001, administrated orally daily on a continuous dosing schedule might: 1. Increases time to disease progression (TTP) based on volumetric MRI measurements in children and adults with NF1 in inoperable documented progressive PN (stratum 1). 2. Results in objective radiographic responses based on volumetric MRI measurements in children and adults with NF1 and inoperable PN in the absence of documented radiographic progression at the trail entry (stratum 2. To evaluate the tolerability and toxicity of chronic RAD001 administration in this patient population as assessed by the NCI Common Toxicity Criteria, version 4.0.
This study will assess the safety and efficacy of secukinumab compared to placebo in patients that have moderate to severe, chronic, plaque-type psoriasis.
The purpose of this study is to determine whether MM-II is effective in the treatment of osteoarthritis, in direct comparison with an approved hyaluronic acid preparation.
In the last few decades much knowledge has been accumulated on the connection between healthy, sufficient sleep and overall health, cognitive function, memory and job or school performance, motor vehicle accidents and work accidents. There has been growing awareness recently of the connection between physical activity and competitive sports performance, and the amount and quality of sleep. Despite the dearth of scientific studies, there is a constant effort to improve understanding in this field. An appropriate procedure designed to evaluate the influence of the quality and amount of sleep on ability and athletic performance must fulfill a number of basic requirements: 1. Isolating the influence of components related to sleep homeostasis and factors relating to circadian rhythm. 2. Neutralizing as much as possible the influence of motivation on the evaluation - one must presumably include a significant competitive event (it is not always possible to do a simple extrapolation between physiological measurements and competitive performance). 3. Isolating and canceling as much as possible additional factors affecting performance, such as: home advantage, weather, injury and field conditions. Athletic activity includes not just competitions but also training towards competitions, since it is difficult to control for influences of competitions and other occasional events, in this study the investigators focus on evaluation of the connection between sleep and athletic performance in training. Towards the end of adolescence, youth are busy in multiple activities related to studies, social obligations and athletic activity. This is also the age they learn to drive. This is an age in which physiologically a person needs more sleep relative to at other ages (9.25 hours of sleep a day), and paradoxically due to the multiple obligations the amount of sleep is lower than needed. Beyond the effect on mood, cognitive performance and memory, sleep deprivation causes far-reaching changes in multiple systems, such as: Cardiovascular System: - Many studies show that shortened sleep duration constitutes an independent cause of increased cardiac events. - Resting heart rate and maximum heart rate decrease after 30 hours of sleep deprivation. Respiratory System: - Significant decline in respiratory function as measured by: FVC, Maximal voluntary ventilation, Maximal static inspiratory/expiratory pressures, Time to exhaustion with exercise, Peak O2 consumption, Peak CO2 production. - Worsening of respiratory sleep disturbances. Digestive System: • Changes in food consumption accompanied by changes in body weight. Neurophysiological System • Disturbance of thermoregulation. Endocrine System: - Hormonal changes associated with hypothalamic-hypophyseal axis - Influence on secretion of Ghrelin and leptin - Influence on secretion of growth hormone. In light of this, there is sound basis for the presumption that athletic performance is connected to these influences directly and indirectly. The purpose of this study is to evaluate the connection between sleep quality and duration and athletic performance among young athletes living and training at the Sport-Gifted Centre at the Wingate Institute.
Clinical effectiveness is of the finest tools to evaluate treatment success and is combined of 3 elements: treatment effectivity, side effect profile and patient compliance. Since the 3 main PDE5i's differ in their molecular structure, therapeutic profile and pharmacokinetics, it seems logical to assume that combining 2 different PDE5i's at lower dosage each may be beneficial in comparison to a single PDE5i maximal dose therapy. The aim of this study is to compare the clinical effectiveness of combination therapy (2 lower-dose PDE5i's) versus single maximal dose PDE5i therapy.
This ia a prospective, randomized, double blind, placebo controlled trial. patients schedule for primary PCI or elective PCI will randomly allocated to receive either a single dose of EPO (Recormon, Roche, Epoetin beta) or saline intravenously before PCI. The investigators assume that the incidence rate of CIN will be significantly lower in the EPO group compared to placebo. In addition, EPO administration will result in a decrease of infarct size.
The purpose of this study is to monitor diarrheal disease and observe changes after the introduction of the rota vaccine.
The purpose of this study is to identify, prior to prescribing, which neuropathic pain patients will benefit from duloxetine more specific the investigators aims are to: - Verify whether presence of chronic pain alters the pain modulation mechanisms, such as DNIC (diffuse noxious inhibitory control) and TS (temporal summation). - Investigate whether anti-neuropathic medications such as duloxetine indeed change the pain modulation profile, and whether this profile change is associated with a reduction of clinical pain.
The purpose of this study is to evaluate the tolerability and safety and to determine whether FXFM244 Antibiotic Foam is effective in the treatment of Acne Vulgaris.
The purpose of the study is to explore the Tolerability and Safety of the H-Coil deep Transcranial Magnetic Stimulation (TMS) in combination with Serotonin Selective Reuptake Inhibitor (SSRI) for Subjects with Major Depression Disorder (MDD) who Complete/ Discontinued the Deep TMS Multicenter study for Subjects with Major Depression Disorder (MDD) (Protocol# CTP-0001-00).