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NCT ID: NCT02357420 Completed - Diabetes Mellitus Clinical Trials

Safety and Efficacy of Relamorelin Administered to Participants With Vomiting Symptoms and Moderate to Severe Diabetic Gastroparesis

Start date: January 29, 2015
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the effects of multiple dose regimens of relamorelin on vomiting episodes, gastric emptying and gastroparesis symptoms in participants with Type 1 and Type 2 diabetes mellitus and gastroparesis. Study drug (relamorelin and placebo) will be administered subcutaneously in a blinded fashion.

NCT ID: NCT02356406 Recruiting - Clinical trials for Digestive System Neoplasms

Celiac Plexus Radiosurgery for Pain Management

Start date: January 2014
Phase: Phase 2
Study type: Interventional

This prospective study evaluates celiac plexus radiosurgery for pain control in patients with upper abdominal malignancies.

NCT ID: NCT02356393 Completed - Clinical trials for Myocardial Infarction

Serum Magnesium Levels in Desalination Tap Water and Outcomes in Acute Myocardial Infarction Patients

Start date: May 2015
Phase:
Study type: Observational

Association between serum magnesium and clinical outcome in patients with acute MI (AMI) with 1 year follow-up in 300 patients in regions supplied by desalinated drinking water (DSW) (Sheba MC) and 150 patients in regions with non-desalinated drinking water (DW) (Nahariya MC).

NCT ID: NCT02356237 Terminated - Clinical trials for Anal Sphincter Injury

The Effect of Episiotomy on Maternal and Fetal Outcomes (EPITRIAL)

Start date: June 2015
Phase: N/A
Study type: Interventional

This study is aimed to evaluate the influence of episiotomy on various maternal and neonatal outcomes. Half of the participants will undergo selective episiotomy (according to routine delivery management at the particular hospital), while the other half will not undergo epitiotomy at all. Our hypothesis is that no differences in maternal and neonatal outcomes will be demonstrated between these two groups.

NCT ID: NCT02355990 Completed - Clinical trials for Primary Open Angle Glaucoma

Minimally Invasive Micro Sclerostomy First in Man Safety and Preliminary Performance Study

Start date: February 1, 2015
Phase: N/A
Study type: Interventional

The study objective is to demonstrate the safety of Minimally Invasive Micro Sclerostomy (MIMS) device for lowering elevated IOP in patients diagnosed with glaucoma.

NCT ID: NCT02352948 Completed - Clinical trials for Non - Small Cell Lung Cancer NSCLC

A Global Study to Assess the Effects of MEDI4736 (Durvalumab), Given as Monotherapy or in Combination With Tremelimumab Determined by PD-L1 Expression Versus Standard of Care in Patients With Locally Advanced or Metastatic Non Small Cell Lung Cancer

ARCTIC
Start date: January 13, 2015
Phase: Phase 3
Study type: Interventional

This study is a Phase III, randomised, open label, multi-centre study assessing the efficacy and safety of MEDI4736 (durvalumab) versus Standard of Care in NSCLC patients with PD-L1 positive tumours and the combination of MEDI4736 (durvalumab) plus tremelimumab (MEDI4736+treme) versus Standard of Care in NSCLC patients with PD-L1-negative tumours in the treatment of male and female patients with locally advanced or metastatic NSCLC (Stage IIIB-IV), who have received at least 2 prior systemic treatment regimens including 1 platinum-based chemotherapy regimen for NSCLC. Patients with known EGFR (Epidermal growth factor receptor) tyrosine kinase (TK) activating mutations and anaplastic lymphoma kinase (ALK) rearrangements are not eligible for the study (prospective testing is not planned within this study). The Standard of Care options are: an EGFR tyrosine kinase inhibitor (erlotinib [TARCEVA®]), gemcitabine or vinorelbine (NAVELBINE®)

NCT ID: NCT02352363 Completed - Clinical trials for Idiopathic Parkinson's Disease

Randomized Safety Study of CVT-301 Compared to an Observational Control Group

Start date: March 2015
Phase: Phase 3
Study type: Interventional

This study is a 12-month, open-label, randomized, multicenter study which will evaluate the safety and efficacy of CVT-301 for the treatment of up to 5 OFF episodes per day in Parkinson's Disease (PD) patients experiencing motor fluctuations (OFF episodes) and will include a concurrent observational cohort of PD patients managed using the usual standards of care.

NCT ID: NCT02351102 Completed - Clinical trials for Congenital Cytomegalovirus Infection

Valacyclovir to Prevent Vertical Transmission of Cytomegalovirus After Maternal Primary Infection During Pregnancy

Start date: November 2015
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to determine whether Valacyclovir treatment, administered during pregnancy after proven primary maternal Cytomegalovirus (CMV) infection, reduces fetal transmission rates and prevents fetal injury in cases of fetal infection.

NCT ID: NCT02350543 Terminated - Clinical trials for Urinary Bladder Neoplasms

Peri-operative Aspirin Continuation Versus Discontinuation

Start date: February 2015
Phase: Phase 4
Study type: Interventional

This study evaluates the continuation (non-discontinuation) of Aspirin during TURBT. Half of participants will continue their usual low-dose Aspirin regimen during TURBT and throughout the perioperative period, while the other half will discontinue Aspirin use ten days prior to surgery (standard recommendation) and restart therapy two weeks post-discharge.

NCT ID: NCT02350504 Completed - Anxiety Level Clinical Trials

Impact of Childrens Preparation Before MRI on Anxiety and Need for Anesthesia: a Prospective Randomized Clinical Trial

Start date: December 2013
Phase: N/A
Study type: Interventional

MRI has been recognized for many years as the safest and the most precise imaging method, particularly for children. However, the accuracy of MRI demands from the patient to avoid any movement while the examination is in process. This task is accomplished with difficulty by children and requires the assistance of an anesthetizing staff. In this research, our main goal is to investigate an introductory instruction as an assistive tool in performing MRI without the need in anesthesia.