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NCT ID: NCT01361607 Completed - Pain Clinical Trials

Sativex® for Relieving Persistent Pain in Patients With Advanced Cancer

SPRAY III
Start date: May 27, 2011
Phase: Phase 3
Study type: Interventional

This 9-week study aimed to determine the efficacy, safety, and tolerability of nabiximols (Sativex®) as an adjunctive treatment, compared with placebo in relieving uncontrolled persistent chronic pain in participants with advanced cancer. Eligible participants were not required to stop any of their current treatments or medications.

NCT ID: NCT01360866 Completed - Depression Clinical Trials

Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial)

Orion
Start date: October 2011
Phase: Phase 3
Study type: Interventional

To assess the long-term safety and tolerability of oral OPC-34712 (brexpiprazole), given in addition to an FDA approved antidepressant (ADT) for the treatment of adults with Major Depressive Disorder (MDD)

NCT ID: NCT01360853 Completed - Clinical trials for Metastatic Pancreatic Adenocarcinoma

Gemcitabine and ON 01910.Na in Previously Untreated Metastatic Pancreatic Cancer

ONTRAC
Start date: May 2011
Phase: Phase 3
Study type: Interventional

The question being asked in this study is: Will patients with advanced pancreatic cancer live significantly longer if they are treated with a combination of Gemcitabine and ON 01910.Na than if they are treated with Gemcitabine alone? There are two parts to this study. In the first part of the study, patients with metastatic pancreatic cancer who have received no prior chemotherapy for this disease will be assigned by chance either to the group that will be treated with both Gemcitabine and ON 01910.Na (about 100 patients will be in this group) or, to the group that will be treated with Gemcitabine only (about 50 patients will be in this group). How long patients survive in the 2 groups will be compared. If it looks like there is no difference between the groups, the study will stop. If it looks like patients in the group that were treated with both Gemcitabine and ON 01910.Na survive longer, the study will continue into a second part where more patients will be treated in order to confirm and better understand the findings of the first part of the study.

NCT ID: NCT01360632 Completed - Depression Clinical Trials

Study of the Safety and Efficacy of Two Fixed Doses of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Polaris Trial)

Polaris
Start date: June 2011
Phase: Phase 3
Study type: Interventional

To compare the effect of OPC-34712 (brexpiprazole) to the effect of placebo (an inactive substance) as add on treatment to an assigned FDA approved antidepressant treatment (ADT) in patients with Major Depressive Disorder who demonstrate an incomplete response to a prospective trial of the same assigned FDA approved ADT

NCT ID: NCT01360554 Completed - Clinical trials for Non-Small Cell Lung Cancer (NSCLC)

ARCHER 1009 : A Study Of Dacomitinib (PF-00299804) Vs. Erlotinib In The Treatment Of Advanced Non-Small Cell Lung Cancer

ARCHER 1009
Start date: June 2011
Phase: Phase 3
Study type: Interventional

This is a multinational, multicenter, randomized,double-blinded, Phase 3 study comparing the efficacy and safety of treatment with PF-00299804 to treatment with erlotinib in patients with advanced non-small cell lung cancer, previously treated with at least one prior regimen. Analyses of primary objective (Progression Free Survival) will be done in two co-primary populations as defined in the protocol.

NCT ID: NCT01360021 Completed - Asthma Clinical Trials

New Breath Actuated MDI Symbicort Compared to Symbicort pMDI and Budesonide pMDI for 12 Weeks Twice a Day

BAI
Start date: November 2011
Phase: Phase 3
Study type: Interventional

This is a comparison of the efficacy of the Symbicort breath actuated dose inhaler to the Symbicort pressured meter dose inhaler after 12 weeks of a twice a day dose.

NCT ID: NCT01359969 Completed - Clinical trials for Hereditary Angioedema

Safety of Ruconest in 2-13 Year Old Hereditary Angioedema (HAE) Patients

Start date: January 17, 2012
Phase: Phase 2
Study type: Interventional

This open-label study is being conducted to confirm the safety, pharmacokinetic profile and efficacy of Ruconest at a dose of 50 U/kg when used for the treatment of acute angioedema attacks in patients, from 2 up to and including 13 years of age.

NCT ID: NCT01359943 Completed - Clinical trials for Rheumatoid Arthritis

Efficacy, Safety and Tolerability of Secukinumab in Patients With Rheumatoid Arthritis Taking Methotrexate

Start date: October 2011
Phase: Phase 2
Study type: Interventional

The study compared the efficacy and assessed the safety of secukinumab given as 3 intravenous (i.v.) loading doses or weekly sub-cutaneous (s.c.) loading doses, compared to placebo, followed by monthly s.c. injections in patients with active Rheumatoid Arthritis (RA) despite treatment with Methotrexate.

NCT ID: NCT01358578 Completed - Clinical trials for Chronic Plaque Psoriasis

Safety and Efficacy of Secukinumab Compared to Etanercept in Subjects With Moderate to Severe, Chronic Plaque-Type Psoriasis

FIXTURE
Start date: June 2011
Phase: Phase 3
Study type: Interventional

This study will assess the safety and efficacy of secukinumab compared to placebo and etanercept in patients that have moderate to severe, chronic, plaque-type psoriasis.

NCT ID: NCT01358357 Completed - Bipolar I Disorder Clinical Trials

Bipolar Maintenance Study of Lurasidone Adjunctive to Lithium or Divalproex

PERSIST
Start date: June 2011
Phase: Phase 3
Study type: Interventional

This is a multi-center, randomized, placebo-controlled, flexible-dose, parallel-group study designed to evaluate the efficacy and safety of lurasidone (in combination with lithium or divalproex) for the maintenance treatment of bipolar I disorder in subjects with or without rapid cycling and /or psychotic features.