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NCT ID: NCT06103994 Completed - Influenza Clinical Trials

Study to Assess the Effect of Multistrain Probiotic on the Immune Response to the Influenza Vaccination

LUPIN
Start date: October 27, 2023
Phase: N/A
Study type: Interventional

A randomized, triple-blinded, placebo-controlled, parallel group study, to assess the effect of multistrain probiotic on the immune response to the Influenza vaccination

NCT ID: NCT06080529 Completed - Clinical trials for Exercise Energy Expenditure

Metabolic Cost of Sandbag Training

Start date: October 15, 2023
Phase: N/A
Study type: Interventional

This study aims at investigating the metabolic cost of several fundamental exercises with sandbag. Sandbag training has become a popular training modality that is efficiently used to improve cardiovascular status and physical performance. Despite its widespread use and popularity the metabolic cost of exercises using sandbag remains to be elucidated. Therefore, the metabolic cost of various fundamental exercise with sandbag will be determined to aid the planning of exercise training programs.

NCT ID: NCT06080516 Completed - Clinical trials for Exercise Energy Expenditure

Metabolic Cost of Kettlebell Training

Start date: October 15, 2023
Phase: N/A
Study type: Interventional

This study aims at investigating the metabolic cost of several fundamental exercises with Kettlebell. Kettlebell training has become a popular training modality that is efficiently used to improve cardiovascular status and physical performance. Despite its widespread use and popularity the metabolic cost of exercises using kettlebell remains to be elucidated. Therefore, the metabolic cost of various fundamental exercise with kettlebell will be determined to aid the planning of exercise training programs.

NCT ID: NCT06071273 Completed - Clinical trials for Cardiovascular Diseases

Online Platform for Self-service of Patients With Chronic Cardiovascular Diseases

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to define the requirements and characteristics of the software that will be developed for the project "Creation of a platform for self-service of people living with chronic cardiovascular diseases in an understandable, clear, complete, consistent and verifiable manner. The project concerns the design and implementation of a long-term program of therapeutic exercise and evaluation, by exercise and health professionals, of the anatomical and functional adaptations of exercise in patients and athletes with cardiovascular diseases. Essentially, it is a program of recording and monitoring cardiovascular rehabilitation in the form of systematic exercise of the patient both at home and in sports venues, which will contribute to the prevention of cardiovascular events in conditions of fatigue and at rest as well as to the gradual rehabilitation of the patient who performs a physical activity. Depending on the individual's functional capacity and health issues, combined with monitoring the patient's vital signs (such as blood pressure, heart rate, oxygen saturation, body temperature) the exercise professional will create an individualized, targeted exercise program with ultimate aiming at its rehabilitation with the help of physical activity and the improvement of its functional performance and by extension the quality of life of the individual. At the same time, the project will seek to motivate patients to remain committed to the physical activity program, with the aim of faster reintegration into their daily life.

NCT ID: NCT06049966 Completed - Clinical trials for Large Cell Neuroendocrine Carcinoma of the Lung

Atezolizumab in Large Cell Neuroendocrine Carcinoma

LANCE
Start date: March 1, 2018
Phase: Phase 1
Study type: Interventional

Large Cell Neuroendocrine Carcinoma (LCNEC) is a rare and aggressive form of cancer that presents significant challenges regarding treatment options and prognosis. In this trial, the effectiveness of Atezolizumab in treating metastatic LCNEC was evaluated. Atezolizumab is an anti-PD-L1 antibody that has shown promising results in other types of cancer, such as small-cell lung Cancer and non-small-cell lung cancer. The trial aimed to assess the efficacy and safety of atezolizumab in combination with chemotherapy as a potential treatment option for treatment-naive patients with metastatic LCNEC The trial was conducted as an open-label, non-randomized study, comparing Atezolizumab plus platinum etoposide to platinum etoposide alone in patients with metastatic LCNEC.

NCT ID: NCT06049693 Completed - Endometrial Cancer Clinical Trials

Iron Prehabilitation in Endometrial Cancer

IROGYN
Start date: January 1, 2023
Phase: Phase 4
Study type: Interventional

Endometrial cancer patients often have iron deficiency anemia before surgery, which can be effectively treated with oral iron supplementation. Anemia and blood transfusions have been previously associated with perioperative infectious diseases. In the present study the investigators will evaluate the impact of perioperative iron supplementation on the incidence of perioperative infections.

NCT ID: NCT06048237 Completed - Clinical trials for Asymptomatic Condition

Investigating Diaphragm Thickness and Mobility in Healthy Parous and Nulliparous Volunteers Using RUSI

Start date: June 1, 2023
Phase:
Study type: Observational

The purpose of this study is to evaluate the intra-rater and inter-rater reliability of diaphragm thickness and excursion measurements by applying Rehabilitative Ultrasound Imaging (RUSI) in a diverse cohort of healthy women, including nulliparous and parous across varying age groups. The diaphragm, which is primarily a respiratory muscle, is also considered to contribute to spinal stability. Utilizing RUSI, a non-invasive and cost-effective imaging modality, we intend to examine diaphragm parameters. Preliminary evidence highlights a potential link between diaphragm dysfunction and musculoskeletal conditions such as lumbopelvic pain. This research hypothesizes that understanding diaphragm behavior in different pathologies, including postpartum recovery and lower back pain, can contribute to tailored rehabilitation strategies, potentially benefiting a wide range of clinical conditions, and facilitating the assessment of intervention effectiveness. Additionally, this study addresses the lack of research on the diaphragm's role in postpartum rehabilitation and offers novel insights into its reliability, particularly within this demographic.

NCT ID: NCT06045377 Completed - Dyslipidemias Clinical Trials

Effect of Armolipid on Lipid Profile in Children With Hypercholesterolemia

Start date: January 20, 2020
Phase: N/A
Study type: Interventional

Data concerning the effectiveness od nutraceuticals in children with dyslipidemia are lacking. The aim of the present study was to evaluate the efficacy and safety of the long-term use of a dietary supplement containing red yeast rice (RYR), combined with other natural compounds, in children and adolescents with hypercholesterolemia. A nutraceutical, containing RYR, polycosanols, coenzyme Q10, astaxanthin and folic acid (commercial name: Armolipid), was administered once-daily in 84 children/adolescents with moderate or severe hypercholesterolemia.

NCT ID: NCT06043492 Completed - Clinical trials for High Intensity Interval Training

Recovery Following Acute Endurance Training

ETRec
Start date: September 30, 2023
Phase: N/A
Study type: Interventional

Aerobic capacity is critical for many athletes, especially for endurance athletes. Althgough several training methods are implemented by coaches to improve endurance performance, recovery following acute endurance training is not adequately studied. However, such information is crucial for coaches to effectively design the most favorable training program, to avoid muscle injuries and overtraining, and ultimately to improve performance of their athletes. This study aims to examine the acute effect of different continuous and HIIT training protocols on indices of metabolism, EIMD, neuromuscular fatigue and performance in middle- and long-distance runners.

NCT ID: NCT06034782 Completed - Diagnosis Clinical Trials

Diagnostic Accuracy of Fine Needle Aspiration in Patients With Salivary Gland Tumors.

Start date: February 22, 2021
Phase:
Study type: Observational [Patient Registry]

Tumors of the salivary glands occupy 0.5-1.2% of cases of head and neck tumors. They are primarily a surgical disease, as their treatment is basically the surgical excision. In this direction and in the context of the differential preoperative diagnosis, in addition to the imaging methods, the fine needle biopsy (FNA) was used, with which cell material is aspirated from the tumor and studied under the microscope. Although an increasing number of papers have been published in the international scientific literature over the last 5 years on the diagnostic accuracy of FNA in salivary glands, many of them are unable to quantify and omit to refer information that could affect the estimated diagnostic accuracy. Such information is for instance the clinical experience of the doctor who performs the FNA and of the one who assess the smear. The aim of this retrospective study is to evaluate the diagnostic accuracy of fine needle biopsy in adult patients with salivary gland tumor that underwent a surgical excision in two Oral and Maxillofacial Departments in Northern Greece. The present retrospective study was carried out from 2/2021 to 4/2022 by collecting data from the files of patients who underwent surgery at the Oral and Maxillofacial Clinic of the Theageneio Cancer Hospital of Thessaloniki 1996-2022 and the General Hospital of Thessaloniki G. Papanikolaou 2015-2022. The study was conducted according to the STARD 2015 protocol. FNA contributed significantly to the differential preoperative process in salivary gland diseases. The differential diagnosis of a lesion in benign / malignant preoperatively, with the use of FNA, enables the surgeon for a more beneficial to the patient and oncologically safer planning of the surgery. It is considered important the high sensitivity provided by the examination, as it helps to exclude with sufficient safety the possible malignancy of the tumor located in the salivary gland of the patient.