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NCT ID: NCT03254537 Enrolling by invitation - Health Status Clinical Trials

Effect of Mediterranean Diets Based on Organic and Conventional Foods

Start date: May 1, 2017
Phase: N/A
Study type: Interventional

Results from a small number of human cohort studies are also available and indicate that there are positive associations between organic food consumption and reduced risk/incidence of certain acute diseases (e.g. pre-eclampsia, hypospadias) and obesity/overweight. Results from animal dietary intervention studies suggest that (i) switching to organic food consumption results in significant changes in hormonal balances and an increase in immune system responsiveness and (ii) differences in pesticide residue, cadmium, protein and antioxidant concentrations between organic and conventional foods are major drivers for hormonal balances and immune system parameters in animals. However, there is virtually no published data from (i) long-term cohort studies focusing on chronic diseases (e.g. cardiovascular disease, diabetes, cancer and neurodegenerative conditions) and (ii) controlled human dietary intervention studies comparing effects of organic and conventional diets. It is therefore currently not possible to assess whether and estimate to what extent organic food consumption may affect human health.

NCT ID: NCT03251469 Recruiting - Hip Fractures Clinical Trials

Single Dose of Tranexamic Acid and Blood Loss, in Elderly Patients With Hip Fracture

Start date: January 2013
Phase: Phase 2
Study type: Interventional

The aim of this study is to investigate the hypothesis that single dose of tranexamic acid (TXA) preoperatively will lower blood loss and transfusion rate in elderly patients with hip fractures (intertrochanteric or Subcapital), that will be treated with intramedullary nailing and cemented hemiarthroplasty respectively. After application of inclusion and exclusion criteria, patients will be randomized in two groups. Group 1 will include patients that receive preoperatively single dose of TXA (15mg/kg) and Group 2 will include patients that receive normal saline (control group).

NCT ID: NCT03248076 Recruiting - Opioid Use Clinical Trials

Effect of Fentanyl on Main Opioid Receptor (OPRM1) on Human Granulosa Cells.

Start date: April 1, 2017
Phase: N/A
Study type: Observational

Opioids is known that produce not only analgesia but also hyperalgesia through activation of central glutaminergic system-GABA. At the same time, recently it was found that the main opioid receptor (OPRM1) is present on human granulosa cells and exogenous opiates and their antagonists can influence granulosa cell vascular endothelial growth factor (VEGF) production via OPRM1, causing ovarian hyperstimulation syndrome. This study aims to investigate if a single exposure to opioids is enough to produce activation of stress mechanism during oocyte retrieval.

NCT ID: NCT03242798 Recruiting - Malnutrition Clinical Trials

Assessment of Nutritional Status of Patients With Liver Cirrhosis

Start date: March 2016
Phase: N/A
Study type: Observational

Cirrhosis is the twelfth leading cause of death worldwide. Malnutrition is prevalent among cirrhotic patients and is an important prognostic factor. Nutritional assessment is therefore crucial for identifying patients at risk or with already established malnutrition and refer them for nutritional intervention and support. In the current literature, nutritional assessment of cirrhotic patients is performed using several tools and methods. However their accuracy is widely affected by the underline disease and its complications. In addition, for the majority of the parameters under study, no gold standard tools and methods have been established so far. Studies on nutritional assessment in cirrhosis usually focus on one or few aspects of nutritional status and not on a full nutritional assessment combining information from medical, biochemical, nutritional, and body composition variables. Hence, the present study aims at a thorough assessment of the nutritional status of 170 cirrhotic patients using multiple widely available tools and methods, in order to assess their accuracy and estimate the prevalence of multiple malnutrition phenotypes such as undernutrition, sarcopenia, sarcopenic obesity and cachexia.

NCT ID: NCT03241394 Recruiting - Obesity Clinical Trials

The Monocyte Subsets in Obese Patients With and Without Metabolic Syndrome

Start date: July 25, 2017
Phase: N/A
Study type: Observational

Obesity is associated with a chronic low-grade inflammation characterized by macrophage infiltration in adipose tissue that induces insulin resistance and the appearance of metabolic syndrome (MS). The aim of the study was the investigation of whether circulating monocyte subsets are differentially regulated in MS.

NCT ID: NCT03240159 Recruiting - Pregnancy, Ovarian Clinical Trials

Long Antagonist Protocol for IVF With Single Luteal Dose of Degarelix

Start date: January 2, 2017
Phase: Phase 3
Study type: Interventional

A prospective study of three different doses of Degarelix in late luteal phase of women undergoing ovarian stimulation for IVF

NCT ID: NCT03232021 Recruiting - Clinical trials for Pregabalin on Catheter Related Bladder Discomfort

Effect of Pregabalin Administration on Catheter- Related Bladder Discomfort in Orthopedic Surgical Operations

Start date: August 16, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of this study is to assess the effect of pregabalin administration on catheter-related bladder discomfort (CRBD). The study group includes patients that are about to be subjected to orthopedic operations.

NCT ID: NCT03229668 Recruiting - Clinical trials for Pregabalin on Catheter Related Bladder Discomfort

Effect of Pregabalin Administration on Catheter- Related Bladder Discomfort in Urological Surgical Operations

Start date: July 28, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of this study is to assess the effect of pregabalin administration on catheter-related bladder discomfort (CRBD). The study group includes patients that are about to be subjected to urological operations because of the high incidence of CRBD observed in this kind of surgical population.

NCT ID: NCT03228485 Not yet recruiting - Clinical trials for Prostatic Hyperplasia

BPH Mobile Application Pilot

Start date: November 1, 2017
Phase: N/A
Study type: Observational

This study assesses the feasibility, and acceptability of a (mobile) application for men presenting at the general practitioner with LUTS/BPH; starting with medical therapy and naïve for treatment. Patients will be enrolled in the study by their general practitioner. The patients will receive a daily medication reminder including frequent feedback on medication adherence. Furthermore standard questionnaires will be filled out via the application. The hypothesis of this pilot study is that application is feasible and accepted in this group of patients.

NCT ID: NCT03226561 Recruiting - Presbyopia Clinical Trials

Assessment of Near Vision Capacity in Different Light Conditions Following Bilateral Trifocal Intraocular Implantation

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

Patients who underwent presbyopic correction with bilateral trifocal intraocular lenses implantation are supposed to have sufficient uncorrected vision capacity for activities of daily living (ADLs) that require near vision acuity (NV), (ie. book reading). However, it is known that light intensity and temperature has a great impact on near vision capacity. Primary objective of this study is to identify the optimal task lighting conditions (in terms of light intensity and temperature) for ADLs that demand near vision acuity for a sample of patients who underwent presbyopic correction with bilateral trifocal intraocular lenses implantation