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NCT ID: NCT03877328 Recruiting - Heart Failure Clinical Trials

BioTechCOACH-ForALL: Development of Mental and Physical Exercise Systems, Clinical Recording, Supervisory Analytical Large-scale Data and Virtual Guidance of Vulnerable Population Groups

Start date: July 18, 2018
Phase: N/A
Study type: Interventional

This would be a single center, parallel, two group randomized controlled pilot study that is designed to assess the feasibility and efficacy of the Virtual Coach Program in elderly patients with heart failure.

NCT ID: NCT03877185 Recruiting - Infertility, Female Clinical Trials

A New Revolutionary 3-Injection- Protocol in Infertile Women

Start date: July 1, 2018
Study type: Observational

This is a prospective randomised study of the evaluation of the clinical IVF results after following a new revolutionary 3-Injection- Protocol for controlled ovarian stimulation in infertile women.

NCT ID: NCT03876782 Completed - Cataract Clinical Trials

Level of Agreement of Intraocular Lens Power Measurements Between IOLMaster and Verion

Start date: December 15, 2017
Study type: Observational

Primary objective of this study is to evaluate the level of agreement of two keratometry modules, the IOLMaster and the Verion Reference Unit, in terms of keratometric values and IOL power calculation.

NCT ID: NCT03871634 Recruiting - Malnutrition Clinical Trials

Assessment of Nutritional Status of Patients With Crohn's Disease

Start date: December 18, 2018
Study type: Observational

Good nutritional status of patients with Crohn's disease (CD) is associated with better outcome of the disease. The prevalence of malnutrition in patients with Crohn's disease varies and is higher in patients with active disease. Available studies in the literature have assessed the nutritional status of patients with Crohn's disease. However, sample size of available studies is small and highly heterogeneous, and most patients are hospitalized with active disease. The aim of the present study is a thorough assessment of nutritional status of 220 patients either with active Crohn's disease or in remission of the disease using multiple widely available tools and methods, in order to assess their accuracy and estimate the prevalence of multiple malnutrition phenotypes such as undernutrition, sarcopenia, sarcopenic obesity and cachexia. Finally, the effect of the nutritional status on the course of the disease will be investigated.

NCT ID: NCT03869437 Not yet recruiting - Clinical trials for Bloodstream Infections

RCT Cefiderocol vs BAT for Treatment of Gram Negative BSI

Start date: April 11, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether a new antibiotic, Cefiderocol which works against a wide variety of gram negative bacteria, is equally effective as the antibiotics that are currently used as current standard of care.

NCT ID: NCT03869190 Not yet recruiting - Clinical trials for Urothelial Carcinoma

A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-based Treatment Combinations in Patients With Locally Advanced or Metastatic Urothelial Carcinoma After Failure With Platinum-Containing Chemotherapy

Start date: April 30, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

A Phase Ib/II, open-label, multicenter, randomized, umbrella study in participants with locally advanced or metastatic Urothelial Carcinoma (UC) who have progressed during or following a platinum-containing regimen. The study is designed with the flexibility to open new treatment arms as new treatments become available, close existing treatment arms that demonstrate minimal clinical activity or unacceptable toxicity, or modify the participant population (e.g., with regard to prior anti-cancer treatment or biomarker status).

NCT ID: NCT03861715 Recruiting - Infertility Clinical Trials

Single Follicular Dexarelix for LH Suppression During Ovarian Stimulation in Oocyte Donors.

Start date: January 2017
Study type: Observational

A randomized prospective study in the evaluation of the long acting GnRH antagonist Degarelix against the classical multidose regime with Ganirelix for LH suppression during the follicular phase of an ovarian stimulation cycle in oocyte donors.

NCT ID: NCT03856476 Recruiting - Clinical trials for Endothelial Dysfunction

The Effect of Childhood Dyslipidemia on Endothelial and Renal Function

Start date: April 3, 2017
Study type: Observational

The aim of the study is to assess if abnormal lipid levels in childhood could cause early damage of the inner layer of the vessels, the endothelium. Dysfunction of the endothelium is the first event in the development of atherosclerosis, is present at all stages of atherosclerosis and is potentially reversible in childhood. It has been suggested that dyslipidemia, via its detrimental effects on endothelium, could impair renal function. This study will assess the dysfunction of the kidneys in children with dyslipidemia.

NCT ID: NCT03854149 Not yet recruiting - Atrial Fibrillation Clinical Trials

A Prospective Study on the Safety and Efficacy of Apixaban for the PReventiOn of ThromboEmbolism in Adults With Congenital HearĪ¤ Disease and Atrial ARrhythmias

Start date: June 2019
Study type: Observational [Patient Registry]

The purpose of this study is to evaluate the safety and efficacy of apixaban for the prevention of thromboembolism in adult patients with congenital heart disease (CHD) and non-valvular atrial fibrillation (NVAF).

NCT ID: NCT03851965 Recruiting - Clinical trials for Surgery--Complications

Assessment of the Soluble Urokinase Plasminogen Activator Receptor in Non-cardiac Surgery (SPARSE)

Start date: February 25, 2019
Study type: Observational

In critically ill patients, the soluble urokinase plasminogen activator receptor (suPAR) level is significantly increased. suPAR is an independent prognostic marker, and the change over time correlates with organ dysfunction. suPAR is elevated and has a prognostic value in patients with systemic inflammatory response syndrome, sepsis/septic shock, burn injuries, and traumatic brain injuries. SPARSE is a prospective observational study aiming to investigate if suPAR measured preoperatively and immediately after surgery can predict the risk of future complications and post-operative mortality in adults following major non-cardiac surgery. Participants will undergo sampling of peripheral venous blood, immediately after arrival to the Operating Room and at the Post-Anesthesia Care Unit, and plasma suPAR levels will be determined. In addition to routine hemodynamic data, sublingual microvascular flow will be measured using noninvasive technology. The primary endpoint will be the presence of complications and/or admission to ICU and/or mortality within the first 60 postoperative days. Target enrollment will be 100 patients.