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NCT ID: NCT03311750 Not yet recruiting - Clinical trials for Advanced Colorectal Cancer

Anti-EGFR Therapy Rechallenge in Combination With Chemotherapy in Patients With Advanced Colorectal Cancer

Start date: October 2017
Phase: Phase 2
Study type: Interventional

A-REPEAT (Anti-Epidermal Growth Factor Receptor -EGFR- rechallenge and plasma genotyping of patients with advanced colorectal tumors) is a Greek, investigator-initiated, single arm open-label phase II study of anti-EGFR therapy rechallenge in combination with chemotherapy in patients with advanced colorectal cancer. Patients with a metastatic, histologically proven colorectal carcinoma RAS wild type will be treated with a combination of panitumumab and third-line irinotecan-based or oxaliplatin-based chemotherapy (FOLFOX,FOLFIRI or irinotecan monotherapy).

NCT ID: NCT03308747 Recruiting - Sarcopenia Clinical Trials

Inflammaging and Muscle Protein Metabolism

Start date: September 1, 2017
Phase: N/A
Study type: Interventional

The development of a low-grade, chronic, systemic inflammation observed in the elderly (inflammaing) has been associated with increased risk for skeletal muscle wasting, strength loss and functional impairments. According to studies performed in animals and cell cultures increased concentrations of pro-inflammatory cytokines such as IL-6 and TNF-α as well as increased levels of hs-CRP lead to elevated protein degradation through proteasome activation and reduced muscle protein synthesis (MPS) via downregulation of the Akt-mTOR signaling pathway. However, evidence regarding the effects of inflammaging on skeletal muscle mass in humans is lacking. Thus, the present study will compare proteasome activation and the protein synthetic response in the fasted and postprandial period between older adults with increased systemic inflammation and their healthy control counterparts.

NCT ID: NCT03306186 Recruiting - Sepsis Clinical Trials

Hemospec Device for the Diagnosis of Sepsis

Start date: October 9, 2017
Phase: N/A
Study type: Interventional

A diagnostic devise, namely HemoSpec, had been developed that integrates clinical information, along with information on circulating protein biomarkers and the morphology of white blood cells to achieve early diagnosis of sepsis. The current study is aiming to validate and improve performance of HemoSpec for the rapid assessment of the critically ill patient.

NCT ID: NCT03304483 Enrolling by invitation - Disorder Heart Clinical Trials

Cardiovascular Responses to Spartathlon Running

Start date: September 29, 2017
Phase: N/A
Study type: Interventional

The aim of this study is to examine the cardiovascular effects of ultramarathon running and their relation to performance.

NCT ID: NCT03298997 Recruiting - Hemorrhoids Clinical Trials

Ligation and Hemorrhoidopexy Technique Versus Ligation of Hemorrhoidal Arteries Using Ultrasound for Hemorrhoids

Start date: October 1, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to compare two techniques for treating hemorrhoids, the ligation and hemorrhoidopexy technique and the conventional ligation of hemorrhoidal arteries using ultrasound, in patients with non-complicated hemorrhoids.

NCT ID: NCT03296423 Recruiting - Infection Clinical Trials

Bacillus Calmette-guérin Vaccination to Prevent Infections of the Elderly

Start date: September 21, 2017
Phase: Phase 4
Study type: Interventional

One small recent trial in elderly volunteers showed that BCG vaccination can protect against infectious complications, while several studies have demonstrated an increased capacity of innate immune responses to react against pathogens. This process, also called trained immunity, generates the hypothesis that BCG vaccination can prevent or delay new infections in the elderly patients and is studied in the ACTIVATE trial

NCT ID: NCT03296163 Not yet recruiting - Clinical trials for Non-small Cell Lung Cancer

A Study Comparing MB02 and Avastin® in Subjects With Stage IIIB/IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Start date: December 2017
Phase: Phase 3
Study type: Interventional

This is a multicenter, multinational, double-blind, 1:1 randomized, parallel-group, equivalence Phase 3 study to compare the efficacy and safety of MB02 plus chemotherapy (carboplatin and paclitaxel) versus Avastin® plus chemotherapy (carboplatin and paclitaxel) in subjects with Stage IIIB/IV non-squamous NSCLC

NCT ID: NCT03295825 Recruiting - Sepsis Clinical Trials

Heparin Binding Protein in Early Sepsis Diagnosis

Start date: September 22, 2017
Phase: N/A
Study type: Interventional

The primary objective of this study is to use heparin-binding protein (HBP) concentration to indicate the presence, or outcome, of sepsis over 72 hours after ED admission. The secondary objectives of this study are to separately evaluate the performance of HBP to predict outcome in patients with suspected infection over 12-24 hours after ED admission.

NCT ID: NCT03292107 Recruiting - Thrombosis Clinical Trials

Study on Management Thrombosis in Greek Cancer Patients

Start date: June 1, 2016
Phase: N/A
Study type: Observational

Study on Management Thrombosis in Greek cancer patients

NCT ID: NCT03290781 Not yet recruiting - Ulcerative Colitis Clinical Trials

Study of the Effect of SHP647 as Maintenance Treatment in Participants With Moderate to Severe Ulcerative Colitis Who Achieved Clinical Response in Induction Studies

Start date: February 22, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy of SHP647 as maintenance therapy in participants with moderate to severe ulcerative colitis (UC) who achieved clinical response in induction studies. This is a phase 3, randomized, double-blind, placebo-controlled, parallel-group efficacy and safety study.