There are about 36633 clinical studies being (or have been) conducted in France. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
Familial Hypercholesterolemia is a common cause of premature coronary heart disease, it is present in 1 per 500 to 1 per 250 people of the general population. Studies on families of Hypercholesterolemia have shown that children with Hypercholesterolemia have a major increase in risk of coronary heart disease after the age of 20. The difference between Hypercholesterolemia and normal children in their atherogenic profil begin at the age of Nowadays , systematic screening techniques are not well implemented whereas their are clear World health organization guidelines. International studies show treatment must be initiated early as at the age of eight years old. In pediatry, Parents can be reluctant to practice blood test on their children. In order to allow more patients to be diagnosed and treated early enough to prevent major complications we need to find an non invasive test. The main objective is to define the level of detection of cholesterol in saliva with two enzymatic tests. Furthermore we aim to evaluate the performance of salivary detection of cholesterol in children.
The purpose of this study is to note that one-stage adjustable surgery can be enough to provide satisfactory results for the correction of strabismus in adults thanks to the use of an anesthesia type AIVOC (Target-controlled infusion of Propofol-Remifentanyl)
Objective of SepSIGN project is to validate biomarkers able to predict the clinical worsening of patients freshly admitted at Emergency Department. Targeted population is adult patients, freshly admitted at ED, with a suspected or confirmed infection.
A study is being carried out to evaluate the biological, technical and clinical/biological efficacy of this technique, the practice of which is standardized in the department, in order to evaluate our practices and to improve them if necessary. As part of this study, the investigators will ask all patients scheduled for this procedure to participate in this observational prospective study without changing usual practices.
The purpose of this study is to assess the safety and tolerability and to determine the dose of IPH5201 that can be used as monotherapy or in combination with durvalumab +/- oleclumab in subjects with advanced solid tumors.
The device that is the subject of this investigation is a robotic assistance module for driving a semi-autonomous electric wheelchair. This module is designed to accessorize the electric wheelchair to improve the safety conditions when driving an electric wheelchair, thus reducing the wheelchair accident rate on the one hand and facilitating access to the wheelchair to persons who can not claim it without the use of a safety device of this type.
The incidence of end stage renal disease (ESRD) is rapidly increasing, now affecting an estimated 7.4 million people worldwide. Numerous parameters such as demographic, clinical and functional factors drive the deterioration of the kidney, ultimately leading to ESRD. Although some ESRD prediction models have been derived in the past years, none of these models are dynamic: they do not integrate the repeated measurements recorded throughout individuals' follow-up. As highlighted in several studies, kidney function repeated measurements (i.e., trajectories) are highly associated with graft survival after kidney transplantation. The investigators made the hypothesis that these trajectories may bring relevant information in the context of graft survival risk prediction model. Hence, combining these trajectories with standard graft survival risk factors may enhance prediction performance. This could permit to derive a robust tool that could be updated over time by continuously capturing patient' personal evolution.
This is a prospective, multi-national, multi-centre, randomized, non-blinded (photo evaluation is blinded), controlled clinical investigation in patients suffering from diabetic wounds reaching to tendon, bone, or joint. Patients will be randomised to received intact fish skin (Kerecis™ Omega3 Wound) plus standard of care or standard of care alone, and wound healing compared over 16 weeks.
Assessment of the acceptability by pregnant women on the research of the potential analgesic function of the clitoris.
Despite increased visibility and acceptance of the LGBT community (Lesbian, Gay, Bisexual and Transgender), in some parts of society, many LGBT people struggle with self-acceptance. Minority Stress Theory, described in the scientific literature, explains that health disparities among populations such as the LGBT population can be explained by stressors induced by a hostile, homophobic culture, which results in harm suffered, expectations of rejection, and internalized homophobia. The harm suffered may include acts of discrimination, harassment, violence (physical or linguistic). But more deeply, two important points of this theory: 1) the expectations of the LGBT person to experience rejection based on their identity and the anti-LGBT social stigma, 2) internalized homophobia, which is a social internalization from negativity against homosexuality and transgender to the initial stages of the identity development of an individual who can continue throughout his life. Perceived harm, stigma and lived rejection are associated with an increased propensity to experience significant psychological pain. LGBT people are more likely to develop self-identification based on sexual orientation or gender, making them more vulnerable to any rejection signal. There is a growing scientific interest around Cognitive and Behavioral Therapies (CBT) of 3rd wave, also called therapies derived from Buddhism, or therapies based on meditation. These programs aim to observe and test, through an experiential meta-cognitive practice, the dogmas or preconceptions (about ourselves, others, and the world) and mental attitudes that guide our choices without our knowledge and are at the origin of suffering, in order to gain inner freedom. These practices constitute an experiential scientific methodology of self-knowledge and reality. These secular programs have become a standard treatment in the management of stress, chronic pain, and the prevention of relapsing depression. In addition, the interest of these practices has been demonstrated in many areas of somatic and psychiatric medicine (including depression and suicidal behavior), but also for the promotion of mental health in the general population. This topic is the subject of more than 15,000 international scientific publications with reading committee (Medline indexed), and of strong interest and shared by both the scientific community and the general public. Scientists are currently deepening these therapies with a focus on wisdom-based self-identification. Beyond the name "therapies", this educational information is key to life for everyone. Who am I ? Am I defined by my social roles, my physical characteristics, my preferences? How to face external challenges? How to develop real self-confidence? Dr Déborah Ducasse offers a conference on the theme: "Sexual orientation, gender: where is the problem?" Nowhere. Self-identification. ". This conference will take place on 05/15/2020, on the occasion of World Day Against Homophobia. In line with the OECD press release in 2019 "The LGBT challenge: how to improve the integration of sexual and gender minorities? "(Panorama de la société 2019: Social Indicators of the OECD), the investigators want to assess whether an intervention targeting valid self-identification can 1) have a positive impact on the acceptance and discrimination indicators of the OECD ; 2) have an impact on valid self-identification. Direct benefits are expected, psychologically and socially, in the fight against discrimination, inclusion and self-acceptance. In the medium and long term: major public health interest via the adaptation of psychoeducational interventions based on self-identification in order to prevent psychosocial risks and suicidal behavior in connection with an altered self-identification based on sexual orientation and gender.