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NCT ID: NCT06256588 Recruiting - Clinical trials for Neoplasms, Head and Neck

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

JADE
Start date: March 21, 2024
Phase: Phase 3
Study type: Interventional

The goal of this study is to assess the safety and effectiveness of Dostarlimab compared to Placebo in adult participants with HNSCC (Head and Neck Squamous Cell Carcinoma)

NCT ID: NCT06256016 Recruiting - Neck Pain Clinical Trials

Effectiveness of Massage of the Thoracic Region in Neck Pain

Start date: April 4, 2024
Phase: N/A
Study type: Interventional

Neck pain is a common disorder in industrialized countries. Manual therapy techniques have been commonly used in the treatment of this problem. Actually, there is no research work that has evaluated the work well of treatment with soft tissue techniques (massage) applied to the dorsal paravertebral muscle in the management of neck pain. The goal of this study (clinical trial) is to compare the efficacy of a massage protocol performed on the dorsal region in subjects with mechanical neck pain. The researchers will compare: A group that will be treated with a local protocol of cervical manual therapy and therapeutic exercise along with the treatment(massage) of the thoracic region. Another group that will be treated only with a local protocol of cervical manual therapy and therapeutic exercise. It is to see if the inclusion of treatment of the thoracic region improves the local intervention in cervical region.

NCT ID: NCT06255665 Recruiting - Clinical trials for Advanced Stage Solid Tumors

A Study of JNJ-79032421 Targeting Mesothelin for Advanced Stage Solid Tumors

Start date: February 9, 2024
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine recommended phase 2 dose(s) (RP2Ds) of JNJ-79032421 and to determine the safety and tolerability of JNJ-79032421 at the RP2D(s).

NCT ID: NCT06255522 Recruiting - Edentulous Mouth Clinical Trials

Clinical and Anatomical Factors Influencing Accuracy in Fully Guided Implant Placement.

Start date: March 1, 2024
Phase: N/A
Study type: Interventional

The importance of the stability of hard and soft tissues has been shown to be of paramount importance for long-term implant success. To reach optimal functional and aesthetic outcomes, implant placement must be planned accordingly to prosthetic needs and design. Prosthetically driven implant placement is based on a diagnostic prosthetic set-up that is followed by precise implant planification and placement using CBCT and intraoral scanning. The aim of this research is to evaluate how the clinical and anatomical factors can influence the 3D position of guided surgery.

NCT ID: NCT06255418 Completed - Heart Failure Clinical Trials

Big Data to Assess the Healthcare and Health Outcomes Burden of Acute Coronary Syndromes Complicated With Heart Failure

BEAT-HF
Start date: January 1, 2012
Phase:
Study type: Observational

The goal of this observational study is to define the incidence of heart failure (HF) after acute coronary syndrome (ACS). The main question it aims to answer is: • To define HF incidence in the medium and long-term in the context of public healthcare coverage ensuring universal access to early coronary revascularization after ACS and extended neurohormonal treatment. Analyses will cover the entire population of Catalonia (North-Eastern region of Spain, N = 7.860.563 in 2020). Researchers will compare HF incidence rate according to relevant subgroup characteristics including event type, age groups or sex, inter alia.

NCT ID: NCT06254638 Recruiting - Physical Activity Clinical Trials

Effectiveness of a Multicomponent Intervention to Promote Physical Activity Levels During the School Day (MOVESCHOOL)

MOVESCHOOL
Start date: September 1, 2023
Phase: N/A
Study type: Interventional

Study based a multicomponent school-based intervention during the school-day (i.e., Physically active learning, active breaks, and active recess) on Physical Activity, health, educational, and cognition outcomes in adolescents.

NCT ID: NCT06254482 Recruiting - Huntington Disease Clinical Trials

An Extension Study to Evaluate the Long-Term Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)

Start date: August 25, 2023
Phase: Phase 2
Study type: Interventional

The primary goal of this study is to evaluate the long-term safety and pharmacodynamic effects of PTC518 in participants with HD.

NCT ID: NCT06254040 Recruiting - Clinical trials for Mild Cognitive Impairment

Effect of Consuming a Mixture of Extracts and DHA on the Mild Cognitive Impairment

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

The objective of this trial is to evaluate the effect of the consumption of a mixture of extracts and DHA on the mild cognitive impairment.

NCT ID: NCT06253221 Recruiting - Clinical trials for Cardiomyopathy, Hypertrophic

A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Start date: April 17, 2024
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of mavacamten in adolescent patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM).

NCT ID: NCT06252818 Recruiting - COPD Clinical Trials

Validation of a Digital Platform for Functional Respiratory Rehabilitation

ReHub
Start date: March 7, 2024
Phase: N/A
Study type: Interventional

Chronic Obstructive Pulmonary Disease (COPD), characterized by persistent airflow limitation in the respiratory airways, is a chronic condition that affects millions of people worldwide. ReHub enables healthcare professionals to design therapeutic exercise programs for the treatment of COPD patients, as well as to analyze and monitor patient rehabilitation through the information and feedback provided via the platform. The main objective of the study is to evaluate the satisfaction and usability of the ReHub platform (for respiratory rehabilitation) among COPD patients and healthcare professionals. This is a single-center satisfaction and usability study on the usage and experience of the ReHub platform (for respiratory rehabilitation).