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NCT ID: NCT03712930 Terminated - Clinical trials for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Treatment of Metastatic Castration-Resistant Prostate Cancer With Homologous Recombination Deficiency

Start date: February 5, 2019
Phase: Phase 2
Study type: Interventional

This study is designed to evaluate the efficacy of pamiparib in participants with metastatic castration-resistant prostate cancer (mCRPC) positive for circulating tumor cells (CTC) with homologous recombination deficiency (CTC-HRD). All participants will receive pamiparib. The purpose of this study is to demonstrate that pamiparib will improve Objective Response Rate (ORR) and Prostate-Specific Antigen (PSA) response rate

NCT ID: NCT03712787 Terminated - Alzheimer's Disease Clinical Trials

An Extension Study of ABBV-8E12 in Early Alzheimer's Disease (AD)

Start date: March 22, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the long-term safety and tolerability of ABBV-8E12 in participants with early AD.

NCT ID: NCT03711162 Terminated - Clinical trials for Idiopathic Pulmonary Fibrosis

A Clinical Study to Test How Effective and Safe GLPG1690 is for Subjects With Idiopathic Pulmonary Fibrosis (IPF) When Used Together With Standard of Care

ISABELA1
Start date: November 28, 2018
Phase: Phase 3
Study type: Interventional

The main purpose of this study was to see how GLPG1690 works together with your current standard treatment on your lung function and IPF disease in general. The study also investigated how well GLPG1690 is tolerated (for example if you got any side effects while on study drug).

NCT ID: NCT03710291 Terminated - Clinical trials for Chronic Kidney Disease

Evaluation of Effect of TRC101 on Progression of Chronic Kidney Disease in Subjects With Metabolic Acidosis

VALOR-CKD
Start date: November 20, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the effect of TRC101 on the progression of chronic kidney disease (CKD) and to evaluate the safety profile of TRC101 in CKD patients with metabolic acidosis.

NCT ID: NCT03709706 Terminated - Neoplasms Clinical Trials

Pilot Immunotherapy Study With Letetresgene Autoleucel (Lete-cel, GSK3377794)T-cells in New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1)/ LAGE-1a-positive Advanced Non-small Cell Lung Cancer (NSCLC) Either Alone or in Combination With Pembrolizumab

Start date: December 31, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This trial will evaluate safety and tolerability of letetresgene autoleucel (GSK3377794) with or without pembrolizumab in participants with non-small cell lung cancer.

NCT ID: NCT03706872 Terminated - Clinical trials for Obese Pregnant Women

Efficacy of an App for Monitoring Physical Activity and Weight of Obese Pregnant Women (Pas&Pes)

Pas&Pes
Start date: July 1, 2018
Phase: N/A
Study type: Interventional

This study evaluate the efficacy of an App for monitoring the physical activity and weight with a smart watch and the provision of virtual advice through messages with a mobile phone in obese pregnant women in the second trimester. Half of the women will be randomized at the intervention group (App + smart watch) and the other half, to the control group who will receive the usual prenatal care.

NCT ID: NCT03703791 Terminated - Peanut Allergy Clinical Trials

Real World, Open Label, QOL Assessment of Peanut Immunotherapy AR101 in Children and Adolescents

Start date: October 24, 2018
Phase: Phase 3
Study type: Interventional

To compare the HRQOL of AR101 characterized oral desensitization immunotherapy (CODITâ„¢) in combination with standard of care (peanut avoidance, education) versus standard of care alone in peanut-allergic subjects aged 4 to 17 years.

NCT ID: NCT03701763 Terminated - Psoriasis Clinical Trials

Efficacy and Safety Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis

Start date: December 19, 2018
Phase: Phase 3
Study type: Interventional

This is a Phase 3, multicenter, randomized, placebo-controlled, double-blind study of the efficacy and safety of apremilast (CC-10004) in pediatric subjects with moderate to severe plaque psoriasis. At least 230 pediatric subjects (ages 6 through 17 years) will be randomized 2:1 to receive either apremilast or placebo for the first 16 weeks and then all subjects will receive apremilast during the 36 week Extension Phase for a total of 52 weeks. Randomization to apremilast arm or placebo arm will be stratified by age group (6 to 11 years or 12 to 17 years). Subjects will receive apremilast treatment of either 20 mg twice daily (BID) or 30 mg BID, depending on weight. This Phase 3 study is being conducted to evaluate the safety and efficacy of apremilast in the treatment of pediatric subjects.

NCT ID: NCT03701438 Terminated - B-cell Malignancies Clinical Trials

Immune Response to Influenza Vaccine in Adults With B-cell Malignancies Treated With Idelalisib

Start date: October 23, 2018
Phase:
Study type: Observational

The primary objective of this study is to assess the immune response to an influenza vaccine in adults with B-cell malignancies who are currently receiving treatment with idelalisib in a Gilead-sponsored study (parent study).

NCT ID: NCT03689829 Terminated - Healthy Clinical Trials

A Study to Test Safety, Tolerability, and the Way the Body Absorbs, Distributes, and Gets Rid of a Study Drug Called MOR106, in Healthy Subjects and in Patients With Moderate to Severe Atopic Dermatitis

Start date: August 13, 2018
Phase: Phase 1
Study type: Interventional

The clinical study consists of three parts: - Part 1 with healthy volunteers. - Part 2 and Part 3 including subjects with moderate to severe atopic dermatitis (a skin disease). For Part 1 the main goal of the study is to compare the safety, tolerability, and exposure of administration of the test drug via an injection in a skin layer just under the surface (subcutaneous), to administration of the test drug into the vein (intravenous). For Part 2 and Part 3 the main goal of the study is to assess the safety and tolerability of administration of the test drug via an injection in a skin layer just under the surface (subcutaneous) during 12 weeks of treatment.