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NCT ID: NCT02687399 Recruiting - Clinical trials for Degenerative Osteoarthritis

Determine the Efficacy of TT-173. Reducing the the Total Blood Loss Associated With Total Knee Arthroplasty (HESTAT)

Start date: January 2016
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to determine the haemostatic efficacy of TT-173, reducing the total blood loss associated with the total knee arthroplasty.

NCT ID: NCT02687321 Recruiting - Ovarian Neoplasms Clinical Trials

The Role of HE4 in the Follow-up of Advanced Ovarian, Fallopian Tube and Primary Peritoneal Cancer

Start date: April 2016
Phase:
Study type: Observational

To evaluate and to compare the effectiveness of CA-125 and HE4 serum levels in epithelial ovarian cancer (OC) in follow-up in terms of time to detection of elevation after the end of the first line treatment. To evaluate the lead-time of the rise of marker levels before epithelial OC recurrence diagnosis by Computed tomography (CT) imaging method. To evaluate the appropriate HE4 cut-off value for follow-up of patients after the treatment of ovarian, Fallopian tube and primary peritoneal cancer.

NCT ID: NCT02686125 Recruiting - Dystonia Clinical Trials

Verciseā„¢ DBS Dystonia Prospective Study

Start date: March 7, 2016
Phase:
Study type: Observational [Patient Registry]

To compile characteristics of real-world outcomes of Boston Scientific Corporation's commercially approved VerciseTM Deep Brain Stimulation (DBS) Systems for the treatment of dystonia.

NCT ID: NCT02685605 Recruiting - Glioblastoma Clinical Trials

Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme

INTRAGO-II
Start date: December 9, 2016
Phase: Phase 3
Study type: Interventional

INTRAGO II resembles a multicentric, prospective, randomized, 2-arm, open-label clinical phase III trial which tests if the median progression-free survival (PFS) of patients with newly diagnosed glioblastoma multiforme (GBM) can be improved by the addition of intraoperative radiotherapy (IORT) to standard radiochemotherapy.

NCT ID: NCT02684318 Recruiting - Breast Cancer Clinical Trials

Study to Evaluate PM01183 in Combination With Olaparib in Advanced Solid Tumors

Start date: July 2015
Phase: Phase 1/Phase 2
Study type: Interventional

Phase Ib/II study to evaluate the efficacy and tolerability of PM01183 in combination with olaparib in patients with advanced solid tumors.

NCT ID: NCT02681432 Recruiting - Clinical trials for Epithelial Ovarian Cancer

Hyperthermic Intraperitoneal Chemotherapy With Paclitaxel in Advanced Ovarian Cancer

hipecova
Start date: January 2012
Phase: Phase 3
Study type: Interventional

Randomized clinical trial to asses the efficacy of closed abdomen hyperthermia intraperitoneal chemotherapy with paclitaxel in ovarian cancer.

NCT ID: NCT02670408 Recruiting - Clinical trials for Cardiac Transplant Disorder

Diagnostic and Therapeutic Applications of Microarrays in Heart Transplantation

Start date: January 2016
Phase:
Study type: Observational

Demonstrate the impact of the Molecular Microscope Diagnostic System as the standard of care for heart transplant patients.

NCT ID: NCT02652897 Recruiting - Surgery Clinical Trials

Hemostasis Alterations in Neurosurgical Patients

ABCD
Start date: May 2016
Phase:
Study type: Observational

Prospective, observational study aimed to investigate the specific hemostatic alterations in patients undergoing glial tumor resection.

NCT ID: NCT02652793 Recruiting - Clinical trials for Human Immunodeficiency Virus

Simplification From Tenofovir Plus Lamivudine or Emtricitabine Plus Ritonavir-Boosted-Protease Inhibitor to Ritonavir-Boosted-Atazanavir Plus Lamivudine in Virologically-Suppressed-HIVInfected Adults With Osteopenia

Osteosimply014
Start date: July 2015
Phase: N/A
Study type: Interventional

A 48-week, open label, non comparative prospective trial in stable chronic human immunodeficiency virus-infected patients having achieved complete virological suppression for more than 24 weeks (human immunodeficiency virus-1 RNA <50 c/ml) switching from an antiretroviral regimen containing tenofovir and lamivudine or emtricitabine and boosted protease inhibitor to boosted atazanavir and lamivudine Study visits will take place at screening, baseline, weeks 4, 12, 24, and 48.

NCT ID: NCT02651662 Recruiting - Clinical trials for Relapsed/Refractory Aggressive B-Cell Lymphoma

A Study to Learn How Safe and Tolerable Odronextamab and Cemiplimab Are in Adult Patients With B-cell Malignancies

CLIO-1
Start date: January 11, 2016
Phase: Phase 1
Study type: Interventional

This study is researching a combination of 2 experimental drugs, referred to as "study drugs", called odronextamab (also known as REGN1979) and cemiplimab (also known as REGN2810). The study is focused on patients who have relapse/refractory aggressive B-cell lymphoma. The aim of the study is to see how safe and tolerable the study drugs are, and to define the recommended dose regimen for the combination with odronextamab. This study is also looking at several other research questions, including: - What side effects may happen from taking the study drugs - How effective the study drugs are against the disease - How much study drug is in the blood at different times - Whether the body makes substances or protein called antibodies against the study drugs (that could make the drugs less effective or could lead to side effects)