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NCT ID: NCT05350228 Recruiting - Clinical trials for Artificial Intelligence

Accuracy of Artificial Intelligence in Evaluation of the Relationship Between Mandibular Third Molar and Mandibular Canal on CBCT

Start date: May 2022
Phase:
Study type: Observational

Convolutional neural network (CNN) are computer applications that assist in the detection and/or diagnosis of diseases by providing an unbiased "second opinion" to the image interpreter10, aiming at improving accuracy and reducing time for analysis. With the rapid growth of Deep Learning (DL) algorithms in image-based applications, CAD systems can now be trained by DL to provide more advanced capability (i.e., the capability of artificial intelligence [AI]) to best assist clinicians).

NCT ID: NCT05349448 Recruiting - Pain, Neuropathic Clinical Trials

Can Dexmedetomidine With Hyalase Augment Quality and Duration of Analgesia When Added to Lumbar Epidural Steroid in Failed Back Surgery. Randomized Double Blind Study

Start date: March 28, 2022
Phase: Early Phase 1
Study type: Interventional

use of dexmedtemodine to augment analgesia in cases of failed back surgery

NCT ID: NCT05348629 Recruiting - COVID-19 Vaccine Clinical Trials

Efficacy and Safety of Covid-19 Vaccine in Cardiac Patients

Start date: June 1, 2022
Phase:
Study type: Observational

Efficacy and safety of covid-19 vaccine in Cardiac patients

NCT ID: NCT05348109 Recruiting - Clinical trials for Cases That Need Extraction of Teeth in Orthodontics

Assessment of Decision Support System Software in Extraction and Anchorage Planning Among Adult Patients Using Computer Algorithm

Start date: August 22, 2022
Phase:
Study type: Observational [Patient Registry]

It was introduced in dentistry to be used in innovative research and development in addition to facilitating the decision in complicated cases and ensure high patient care quality. In the field of Orthodontics in specific, many studies previously mentioned the idea of artificial intelligence showing very promising results and high degree of reliability. It was used in different domains in orthodontics like diagnosis, treatment planning, evaluation of treatment outcome

NCT ID: NCT05347940 Recruiting - Hand Tendon Injury Clinical Trials

EFFICACY OF MIRROR THERAPY IN IMPROVING HAND FUNCTION POST FLEXOR TENDON REPAIR

Start date: June 5, 2022
Phase: N/A
Study type: Interventional

This current study will be designed to prove the therapeutic effect of mirror therapy on physical function of the hand after flexor tendon repair

NCT ID: NCT05347459 Recruiting - Type 2 Diabetes Clinical Trials

Cognitive Protective Effect of Newer Antidiabetic Drugs

Start date: March 2, 2022
Phase:
Study type: Observational

The proposed study aims to: 1. Explore the cognitive protective effects of SGLT2 inhibitors and DPP-4 inhibitors in patients attending diabetic clinics in Alexandria 2. Examine the possible relationship of such effects with the systemic inflammatory and metabolic status in these patients 3. Undertake a network analysis to elucidate the potential pathways linking the observed protective effects, if any, with the observed changes in inflammatory or metabolic parameters

NCT ID: NCT05346666 Recruiting - Epilepsy Clinical Trials

Possible Immuno-Modulatory Effect of Tocilizumab in Patients With Refractory Status Epilepticus.

Start date: June 25, 2022
Phase: Phase 3
Study type: Interventional

Recently, the pathogenesis of epilepsy is immuno-modulatory and neuro-inflammatory which is commonly activated in epileptogenic brain regions in humans and is clearly involved in animal models of epilepsy. Inflammatory mediators in the blood and molecular imaging of neuro-inflammation could provide diagnostic, prognostic, and predictive biomarkers for epilepsy, which will be instrumental for patient stratification in future clinical studies. Dysfunction of the blood-brain barrier (BBB) may be responsible for abnormal neuronal firing. Disruption of the BBB causes the leakage of serum protein and leucocyte invasion into the brain. These exogenous inflammatory mediators have the potential to lower seizure thresholds, which could alter channel sensitivity, neurotransmitter uptake or release, and glia-associated regulation of extracellular environments, such as potassium concentration.

NCT ID: NCT05345782 Recruiting - Clinical trials for Chronic Idiopathic Pain Syndrome

Laparoscopic Combined Hypo Gastric Neural Plexus Block and Uterosacral Nerve Block for Patients With Chronic Idiopathic Pelvic Pain

Start date: April 20, 2022
Phase: N/A
Study type: Interventional

Often the etiology of chronic pelvic pain is not clear, as there are many disorders of the reproductive tract, gastrointestinal system, urological organs, musculoskeletal system, and psych neurological system that may be associated with chronic pelvic pain. An effective treatment for this condition has evaded the medical profession for centuries. Even today only 20-25% patients respond to conservative management.5 When such treatment fails, a diagnostic laparoscopy is performed.1, 3, 6 the cause of the pain is not always obvious as no pathology is seen in 40-60% of the cases.1

NCT ID: NCT05345756 Recruiting - Clinical trials for Orthodontic Appliance Complication

Intraoral Maxillary Protraction Technique vs Facemask Using Alt-RAMEC Protocol for Treatment Class III Growing Patients

ALT-RAMEC
Start date: May 1, 2022
Phase: N/A
Study type: Interventional

The study compares use of intraoral technique for maxillary advancement and extra oral technique with hep of protocol called Alt-RAMEC which depends on repeated expansion and constriction of maxilla to help in maxillary protraction

NCT ID: NCT05345132 Recruiting - Clinical trials for Threatened Preterm Labor

Nifedipine Plus Magnesium Sulfate Versus Magnesium Sulfate for Very Early Preterm Tocolysifs

ASTOS1
Start date: April 10, 2022
Phase: N/A
Study type: Interventional

Objective: This trial is designed to compare between the effectiveness of nifedipine plus magnesium sulfate (MgSO4) and MgSO4 alone for tocolysis in women with threatened preterm labor. Patient Population: The population will include pregnant women at gestational age between 28 and 31 weeks who are 18 years old or older and have signs of threatened preterm labor. Study Design: This is a single-center, prospective, randomized controlled clinical trial. A total of 264 women pregnant between 28 and 31 weeks having threatened preterm labor will be enrolled and randomized into two parallel treatment arms. Patients in the group A will receive nifedipine plus MgSO4, while patients in group B will MgSO4 only. Treatment: All patients will be randomized on the day of enrollment. Patients with threatened preterm labor will receive the respective tocolysis in each group. All patients will receive corticosteroids for lung maturity according to the local protocol. Primary outcome: Number of women not delivered within 48 hours of starting tocolytic therapy. Secondary outcomes: perinatal mortality, a composite of adverse neonatal outcomes, birth weight, days on ventilation support, length of admission in neonatal intensive care, prolongation of pregnancy more than 7 days, delivery after 37 weeks of gestation, number of days till delivery, maternal mortality, maternal infection, and harm to mother from intervention.