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NCT ID: NCT05782985 Recruiting - Clinical trials for Myeloproliferative Neoplasms (MPNs)

Expression Pattern of HNRNPH1 and HNRNPK Genes in MPNs

Start date: March 20, 2023
Phase:
Study type: Observational

The aim of the study is to evaluate the expression pattern of heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1) and K (HNRNPK) genes in Myeloproliferative neoplasms as a possible indicator of disease progression and as a potential therapeutic target

NCT ID: NCT05782595 Recruiting - Clinical trials for Postmenopausal Women

Body Balance Responses to Aquatic Therapy Among a Cohort of Healthy Postmenopausal Women

Start date: February 10, 2023
Phase: N/A
Study type: Interventional

the aim of this study is to investigate the effect of aquatic Exercises on balance in healthy postmenopausal women .

NCT ID: NCT05781854 Recruiting - Labor Pain Clinical Trials

Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia

Start date: May 29, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of this study is to compare two modes of labour epidural analgesia: programmed intermittent epidural boluses (PIEB) versus continuous epidural infusion (CEI), with patient controlled epidural analgesia (PCEA), using dexmedetomidine in addition to low-dose bupivacaine and through measuring the total volume of local anesthetic received through patient controlled epidural analgesia per hour

NCT ID: NCT05781815 Recruiting - Clinical trials for Trochanteric Fractures

Treatment Of Unstable Trochanteric Fracture: A Comparative Study Between DHS And DHS With Trochanteric Stabilization Plate

Start date: February 10, 2023
Phase: N/A
Study type: Interventional

compare the results in treatment of unstable trochanteric fracture by using DHS and DHS with Trochanteric Stabilizing plate as regard shaft medialization.neck shaft angle measurment and shaft migration

NCT ID: NCT05781711 Recruiting - Parkinson Disease Clinical Trials

Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease

Start date: January 6, 2023
Phase: Phase 2
Study type: Interventional

Parkinson's disease (PD) is one of the most common neurodegenerative diseases characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra compacta (SNc) and aggregation of Lewy bodies in neurons. Although aging, oxidative damage and neuroinflammation have been recognized to play crucial roles in the pathogenesis of PD, the precise etiology remains obscure. Emerging evidence suggests PD is a systemic metabolic disease, and metabolic abnormality correlates with functional alternations in PD

NCT ID: NCT05781698 Recruiting - Clinical trials for Inflammatory Bowel Diseases

Repurposing Fenofibrate in Modulating mTOR/NLRP3 Inflammasome in Patients With Ulcerative Colitis

Start date: March 20, 2023
Phase: Phase 2
Study type: Interventional

Fibrates, specific pharmacological agonists of PPARα, have been widely used to treat hypercholesterolemia and hypertriglyceridemia. Apart from their metabolic action, anti-inflammatory properties of fibrates have been described, including inhibition of NF-kappa B signaling and pro-inflammatory cytokine production. 4 Fenofibrate, an important peroxisome proliferator-activated receptor-a (PPAR- α) agonist, is widely used in clinical as a triglyceride (TG)-lowering agent

NCT ID: NCT05781139 Recruiting - Dementia Clinical Trials

Comparative Study Between Alzheimer's and Multi-infarct Dementia

Start date: March 10, 2023
Phase:
Study type: Observational

Dementia is a neurological disease that causes cognitive and behavioral impairments that could ultimately interfere with the ability to function at work or to do the usual daily activities. It is recognized as a healthcare and social burden and remains challenging in terms of proper diagnosis and treatment.

NCT ID: NCT05779800 Recruiting - Free Gingival Graft Clinical Trials

The Use of Flowable Resin Composite Stent in Reduction of Donor Site Morbidity After Free Gingival Graft Harvesting

Start date: February 15, 2023
Phase: N/A
Study type: Interventional

After harvesting free gingival graft from the hard palate, Postoperative pain as well as bleeding are the most common complications.Different agents were used to protect the denuded areas on the palate as gelatin sponge, Hyaluronic acid gel and platelet rich fibrin (PRF) but still no gold standard material is present. PICO format: P: patients with mucogingival problems in need for free gingival graft or de-epithelialized connective tissue graft.I: Flowable resin composite stent. C: Periodontal pack. O: Post-operative pain T: day 3, 7, 14, 21 and 42 postoperative. Aim of the study: To compare the effect of flowable composite stent versus periodontal pack applied to palatal donor site after free gingival graft harvesting in terms of post-operative pain reduction.

NCT ID: NCT05779657 Recruiting - Clinical trials for Generalized Convulsive Status Epilepticus

Combined Ketamine and Midazolam for Generalized Convulsive Status Epilepticus

Ket-Mid
Start date: March 21, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

Generalized convulsive status epilepticus (GCSE) is a common neurological emergency in children. Benzodiazepines are the recommended first line antiseizure medication (ASMs), but they fail to control seizures in a third of cases. Combination of benzodiazepines with another ASM that has a different mechanism of action may be a promising option for faster control of GCSE. In this study, the investigators aim to evaluate the efficacy and safety of ketamine plus midazolam versus midazolam alone as first-line therapy of pediatric GCSE.

NCT ID: NCT05779345 Recruiting - Bone Resorption Clinical Trials

Stability of Short Implants Versus Standard Blx Implants With Internal Sinus Floor Elevation in Posterior Maxilla

Start date: March 2, 2023
Phase: N/A
Study type: Interventional

Implants in the maxillary posterior region are associated with compromised bone in both quantity - notably in vertical dimension- and quality. Along with the fact that the posterior teeth are subjected to higher occlusal forces than the anterior teeth (Marianne Morand & Tassos Irinakis, 2007). In order to overcome these shortcomings, various procedures have been advocated including open and closed sinus lift (Nkenke E & Stelzle F, 2009; Schropp et al, 2003). The use of short implants is a valid alternative for these procedures (Wallace SS & Froum SJ, 2003) sparing the need of applying augmentation techniques with the associated increased time, morbidity and complexity of such procedures.