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NCT ID: NCT02782663 Active, not recruiting - Clinical trials for Crohn's Disease (CD)

A Study to Evaluate the Long-Term Efficacy, Safety, and Tolerability of Repeated Administration of Upadacitinib (ABT-494) in Participants With Crohn's Disease

Start date: May 18, 2016
Phase: Phase 2
Study type: Interventional

This is a open-label extension (OLE) study designed to evaluate the long-term efficacy, safety, and tolerability of Upadacitinib (ABT-494).

NCT ID: NCT02772549 Active, not recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Early Diagnosis of Pulmonary Fibrosis - Diagnostic Delay

Start date: March 2016
Phase:
Study type: Observational [Patient Registry]

Patients with newly diagnosed IPF are investigated for the diagnostic delay before a diagnosis of IPF is made.

NCT ID: NCT02764619 Active, not recruiting - Atrial Fibrillation Clinical Trials

Inhibition of Aldosterone to Reduce Myocardial Diffuse Fibrosis in Patients With Paroxysmal and Persistent Atrial Fibrillation in Preventing Recurrent Episodes of Atrial Fibrillation

INSPIRE-AF
Start date: December 2013
Phase: Phase 3
Study type: Interventional

A randomized, double-blinded, placebo-controlled study to evaluate the effect of spironolactone in addition to conventional treatment compared with placebo in patients with paroxysmal and persistent atrial fibrillation with preserved left ventricular ejection fraction by T1 mapping, structure and function of left atrium and ventricle assessed by transthoracic echocardiography and cardiac magnetic resonance (CMR), the number of recurrent episodes of atrial fibrillation and biomarkers measured in blood.

NCT ID: NCT02755441 Active, not recruiting - Clinical trials for Idiopathic Pulmonary Fibrosis

Pulmonary Fibrosis Biomarker Cohort - a Prospective Cohort of Incident Patients With IPF

PFBIO
Start date: April 2016
Phase:
Study type: Observational

Incident patients with idiopathic pulmonary fibrosis (IPF) in Denmark will be offered inclusion and followed up for up to 5 years with measurements of blood biomarkers and measurements of disease progression.

NCT ID: NCT02748460 Active, not recruiting - Uterine Fibroids Clinical Trials

Non-interventional Study to Evaluate Long Term Safety, Prescription Management Patterns of Esmya in a Long Term Setting

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Start date: December 2015
Phase:
Study type: Observational

This is a multi-centre, multinational, prospective, non-interventional study in females with a diagnosis of moderate to severe uterine fibroids, and for whom a treatment with Esmya in a long term manner is planned, and in subjects who were previously exposed to UPA in the long term Phase III studies.

NCT ID: NCT02746081 Active, not recruiting - Solid Tumors Clinical Trials

Phase I Study of BAY1436032 in IDH1-mutant Advanced Solid Tumors

Start date: May 26, 2016
Phase: Phase 1
Study type: Interventional

The primary objective of this study is: - Determine the safety, tolerability, maximum tolerated dose (MTD) or recommended Phase II dose (RP2D) of BAY 1436032 in patients with isocitrate dehydrogenase-1 (IDH1)-R132X-mutant advanced solid tumors. The secondary objectives of this study are: - Evaluate the pharmacokinetics (PK) of BAY1436032 in patients with IDH1-R132X-mutant advanced solid tumors. - Evaluate the effect of a standard high-fat, high calorie meal on the PK of BAY1436032. - Assess pharmacodynamic (PD) effects and evidence of clinical efficacy associated with BAY1436032 administration in patients with IDH1-R132X-mutant advanced solid tumors.

NCT ID: NCT02743494 Active, not recruiting - Advanced Cancer Clinical Trials

An Investigational Immuno-therapy Study of Nivolumab or Placebo in Participants With Resected Esophageal or Gastroesophageal Junction Cancer

CheckMate 577
Start date: July 14, 2016
Phase: Phase 3
Study type: Interventional

The primary purpose of this study is to determine whether Nivolumab will improve disease-free survival compared with placebo.

NCT ID: NCT02731235 Active, not recruiting - Stroke, Lacunar Clinical Trials

The Effect of Aerobic Exercise in Patients With Lacunar Stroke

HITPALS
Start date: January 2016
Phase: N/A
Study type: Interventional

In a randomized-controlled study the effect of high-intensity training, 5 days a week at home for 12 weeks is tested in patients with lacunar stroke.

NCT ID: NCT02711553 Active, not recruiting - Metastatic Cancer Clinical Trials

A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer

Start date: May 19, 2016
Phase: Phase 2
Study type: Interventional

The main purpose of this study is to evaluate the efficacy and safety of ramucirumab or merestinib or placebo plus cisplatin and gemcitabine in participants with advanced or metastatic biliary tract cancer.

NCT ID: NCT02705300 Active, not recruiting - Colorectal Cancer Clinical Trials

Side Effects to FOLFOXIRI + Tocotrienol/Placebo as First Line Treatment of Metastatic Colorectal Cancer

Start date: May 6, 2016
Phase: Phase 2
Study type: Interventional

Treatment with FOLFOXIRI (5-fluorouracil, oxaliplatin, irinotecan) can be effective, but it has serious side effects, which may require hospitalization. The purpose of this study is to investigate whether the addition of tocotrienol can reduce the side effects to FOLFOXIRI otherwise leading to hospitalization.