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NCT ID: NCT04715321 Recruiting - Clinical trials for Hepatocellular Carcinoma

CT Perfusion Parameters Predict Vascular Pattern in Hepatocellular Carcinoma

Start date: February 15, 2013
Phase:
Study type: Observational

Distinct vascular patterns (ECTC or Non-ECTC) of tumors plays an important role in tumor migration, metastasis and drug resistant in hepatocellular carcinoma (HCC). However, there is no non-invasive method to predict vascular pattern in clinical. In the present study, we prospectively assess CT perfusion parameters for evaluation of the vascular pattern in HCC.

NCT ID: NCT04715217 Recruiting - Lymphoma, B-Cell Clinical Trials

Targeting CD19 and CD22 CAR-T Cells Immunotherapy in Patients With Relapsed or Refractory B Cell Lymphoma

Start date: January 4, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

Evaluation the safety,tolerability, preliminary efficacy,and PK/PD of CD19-CD22 CAR-T cells for the treatment of B cell lymphoma.

NCT ID: NCT04714918 Recruiting - Clinical trials for Chronic Kidney Diseases

Chinese CKD-MBD Prevalence Survey (CRISS-MBD)

Start date: November 29, 2020
Phase:
Study type: Observational

This is a multi-center cross sectional epidemiological study. The purpose of this study is to investigate the prevalence of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) in Chinese population.

NCT ID: NCT04714827 Recruiting - Multiple Myeloma Clinical Trials

Targeting CD19 and BCMA CAR-T Cells Immunotherapy in Patients With Relapsed or Refractory Multiple Myeloma

Start date: January 22, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

Evaluation the safety,tolerability, preliminary efficacy,and PK/PD of KQ-2003 CAR-T cells for the treatment of multiple myeloma

NCT ID: NCT04714814 Recruiting - Clinical trials for Colorectal Cancer Stage IV

Mechanisms of Fate Evolution of Colorectal Adenocarcinoma Metastasis

Start date: June 1, 2021
Phase:
Study type: Observational

This is a two stage nested case-control study to construct the hologram plane , explore biomarkers and screening original drugs of metastatic colorectal cancer.

NCT ID: NCT04714593 Recruiting - Clinical trials for Acute Lymphocytic Leukemia, B-Cell

Targeting CD19 and CD22 CAR-T Cells Immunotherapy in Patients With Relapsed or Refractory Acute B Lymphocytic Leukemia

Start date: January 15, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

Evaluation the safety,tolerability, preliminary efficacy,and PK/PD of CD19-CD22 CAR-T cells for the treatment of acute B lymphocytic leukemia.

NCT ID: NCT04714489 Recruiting - Bronchial Asthma Clinical Trials

Public Title:A Study on the Registration of The Use of Feilike HeJi in Adults

Start date: January 16, 2021
Phase:
Study type: Observational [Patient Registry]

Feilike HeJi is produced by Guizhou Jianxing Pharmaceutical Co. LTD. For the treatment of phlegm heat caused by lung cough phlegm yellow, bronchial asthma, bronchitis, see the syndrome of proprietary Chinese medicine (approval number: Z20025136) approved by the state and the drug from radix scutellariae, radix peucedani, radix stemonae, red gentian root of deal, phoenix tree, spreading hedyotis herb, red tube 7 flavour, with qingrejiedu, antitussive expectorant effect. In order to fully understand the safety of Feilike HeJi in clinical practice and fulfill the responsibility of production enterprises for patients, the production enterprises initiated this study to further evaluate the safety and understanding of the function characteristics of Feilike HeJi in a wide range of people, so as to guide the clinical rational drug use.

NCT ID: NCT04714294 Recruiting - Healthy Clinical Trials

Evaluate the Safety, Tolerability and Pharmacokinetics Characteristics of HPP737 in Healthy Volunteers

Start date: September 8, 2020
Phase: Phase 1
Study type: Interventional

Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable disease characterized by persistent respiratory symptoms and incompletely reversible airflow limitation. It is usually caused by airway and / or alveolar abnormalities caused by obvious exposure to toxic particles or gases.COPD is currently the fourth leading cause of death in the world, and is expected to be the third leading cause of death by 2020.HPP737 as an oral PDE4 inhibitor for the treatment of COPD.Preclinical data showed that the activity of HPP737 was similar to that of rofloxacin, but HPP737 significantly reduced the permeability to CNS and may have better tolerance. HPP737 will be used to develop indications for chronic obstructive pulmonary disease, and PK study in Chinese people is going to to evaluate the safety and tolerability of HPP737 in healthy volunteers.

NCT ID: NCT04714190 Recruiting - Gastric Cancer Clinical Trials

A Study of RC48-ADC in Local Advanced or Metastatic Gastric Cancer With the HER2-Overexpression

Start date: March 24, 2021
Phase: Phase 3
Study type: Interventional

This is a Phase III, randomized, multicenter, open-label clinical trial designed to compare RC48-ADC to physician choice standard treatment in participants with human epidermal growth factor receptor 2 (HER2)-overexpression locally advanced or metastatic gastric cancer.

NCT ID: NCT04713956 Recruiting - Clinical trials for Myelodysplastic Syndrome

G-CSF+DAC+BUCY vs G-CSF+DAC+BF Conditioning Regimen for RAEB-1,REAB-2 and AML Secondary to MDS Undergoing Allo-HSCT

Start date: January 15, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

Allo-HSCT is the most effective way to cure MDS and AML secondary to MDS. At present, the best conditioning regimen for MDS and AML secondary to MDS undergoing allo-HSCT remains in discussion. In this prospective study, the safety and efficacy of G-CSF+DAC+BUCY and G-CSF+DAC+BF conditioning regimens in RAEB-1, REAB-2 and AML secondary to MDS undergoing allo-HSCT are evaluated.