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NCT ID: NCT06385444 Not yet recruiting - Clinical trials for Psychological Stress

IVF Failure and Pregnancy Loss on Couples' Psychological Stress

Start date: May 1, 2024
Phase:
Study type: Observational

The goal of this observational study is to learn about The purpose of this study was to compare the psychological differences between couples after IVF transplant failure and IVF pregnancy loss, including the differences in anxiety, depression, stress and post-traumatic stress between women and their spouses. The main question it aims to answer is: What are the psychological effects of IVF implantation failure and IVF pregnancy loss on women and the psychological differences between couples? Participants already taking IVF as part of their regular medical care will answer online survey questions about their joint pain for 1 years.

NCT ID: NCT06385418 Recruiting - Colorectal Cancer Clinical Trials

Fluorouracil Treatment Via Colon for Colorectal Cancer

Start date: May 1, 2024
Phase: Phase 2
Study type: Interventional

Fluorouracil (5-FU) is a commonly used drug for colorectal cancer (CRC). Thermosensitive hydrogel presents a promising carrier for 5-FU to address challenges encountered with traditional administration methods. We propose an integrated approach utilizing colonic transendoscopic enteral tubing to cover the entire colon flexibly, coupled with a thermo-sensitive gel to enhance the adhesion of 5-FU. This clinical trial aims to assess the feasibility, safety, and efficacy of this approach for treating CRC.

NCT ID: NCT06385405 Recruiting - Clinical trials for Major Depressive Disorder (MDD)

Electroencephalography-based Precise Repetitive Transcranial Magnetic Stimulation Treatment

Start date: May 27, 2024
Phase: N/A
Study type: Interventional

This study will focus on the hypothesis that repetitive transcranial magnetic stimulation (TMS) based on EEG personalized modulation may be more effective in promoting symptomatic relief of major depressive disorder (MDD), and will rely on the platform of neuroimaging and function brain imaging of Shanghai Mental Health Center (SMHC), an authoritative institution in the field of mental health. We will eventually facilitate optimization of physical therapy for major depressive disorder (MDD).

NCT ID: NCT06385379 Recruiting - Clinical trials for Aortic Arch Aneurysm

Guo's Aortic Arch Reconstruction: A Multicenter, Prospective Study of the Novel WeFlow-Tribranch System (GENIUS Study)

Start date: June 30, 2024
Phase: N/A
Study type: Interventional

A prospective ,Multiple Center Study About the Safety and Efficacy of WeFlow-Tribranch Embedded Aortic Triple-branch Arch Stent Graft System manufactured by EndoNom Medtech (Hangzhou) Co., Ltd. for true/pseudo aortic arch aneurysms and ulcers involving aortic arch . (GENIUS Study)

NCT ID: NCT06385158 Recruiting - Healthy Volunteer Clinical Trials

A Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Oral Dose Escalation of GS1-144 Tablets and the Effects of Food on the Pharmacokinetics of GS1-144 in a Chinese Population

Start date: April 2024
Phase: Phase 1
Study type: Interventional

A Phase I clinical study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral dose escalation of GS1-144 tablets and the effects of food on the pharmacokinetics of GS1-144 in a Chinese population

NCT ID: NCT06385145 Not yet recruiting - Clinical trials for Pediatric Growth Hormone Deficiency (PGHD)

A Bioavailability Study of Two Different PEG-rhGH Preparations.

Start date: May 8, 2024
Phase: Phase 1
Study type: Interventional

The purpose of this study is to compare the pharmacokinetics of the two different PEG-rhGH preparations.

NCT ID: NCT06385093 Not yet recruiting - Clinical trials for Rheumatoid Arthritis

A Study on the Prevention and Treatment of GIOP With Eldecalcitol

ELEGANT
Start date: June 2024
Phase: Phase 4
Study type: Interventional

The study will be a multi-center, randomized, open label, parallel trial conducted in rheumatoid arthritis patients treated with glucocorticoids. After signing the informed consent, all patients will be screened as per the inclusion and exclusion criteria. Estimated 314 eligible patients will be enrolled. The enrolled patients will be randomly assigned to either Eldecalcitol group or Alfacalcidol group in a 1:1 ratio and followed up for 12 months. On-site follow up visits will be conducted at Month 6 and 12 after enrollment. The study is designed to evaluate the efficacy and safety of Eldecalcitol in preventing glucocorticoid-induced bone loss in rheumatoid arthritis patients.

NCT ID: NCT06384482 Recruiting - Clinical trials for Recurrent/Refractory Small Cell Lung Cancer Lung Large Cell Neuroendocrine Carcinoma

SNC115 Injections in Patients With Recurrent/Refractory Small Cell Lung Cancer and Lung Large Cell Neuroendocrine Carcinoma

Start date: April 30, 2024
Phase: Phase 1
Study type: Interventional

This study is a FIH dose escalation clinical study, with single arm, open label and design, in order to observe the preliminary safety and Pharmacokinetic of SNC115 Injection in participants with Recurrent/refractory small cell lung cancer and Lung large cell neuroendocrine carcinoma.

NCT ID: NCT06384118 Completed - Clinical trials for Type 2 Diabetes Mellitus

Effects of a Health Intervention on Hypoglycemic Coping : a Pilot Study

Start date: August 1, 2023
Phase: N/A
Study type: Interventional

From August 2023 to January 2024, 100 patients with type 2 diabetes who met the inclusion and exclusion criteria were selected from the endocrinology department of The purpose of this study was to construct a hypoglycemia coping intervention program for type 2 diabetic patients based on the IMB theory and to investigate the feasibility, acceptability, and initial effects of the program.

NCT ID: NCT06383923 Recruiting - Clinical trials for Placenta Accreta Spectrum

Risk Factors, Prognosis and Prediction Models for Placenta Accreta Without Prior Cesarean Section

Start date: January 1, 2023
Phase:
Study type: Observational

1. Identify the risk factors for Placenta accreta spectrum (PAS) disorders in women without prior caesarean section (CS). 2. Clarify the prognostic factors of the disease and explore individualized treatment options to improve the prognosis of patients with this type of disease; 3. Use the cohort's biological sample database to conduct serology, cytology, and histology studies to explore the abnormal uterine immune microenvironment and the impact on uterine spiral artery remodeling in non-scar uterine-placenta accreta disease.