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NCT ID: NCT05024214 Recruiting - Clinical trials for Non-small Cell Lung Cancer

Phase Ib/II Trial of Envafolimab Plus Lenvatinib for Subjects With Solid Tumors

Start date: November 15, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

This is an open-label, multi-center study of Phase Ib/II study to assess the efficacy and safety of Envafolimab combinded with Lenvatinib in the treatment of subjects with advanced solid tumors. The primary hypothesis of this study is that subjects will have a better objective response rate (ORR) when treated with Envafolimab plus Lenvatinib than SOC.

NCT ID: NCT05023915 Recruiting - Clinical trials for Immune Thrombocytopenia

A Multicenter Randomized Open-label Study of Diammonium Glycyrrhizinate Enteric-coated Capsule Plus DXM Versus DXM in Treatment of ITP

Start date: August 21, 2021
Phase: Phase 2
Study type: Interventional

The project was undertaking by Qilu Hospital of Shandong University in China. In order to report the efficacy and safety of diammonium glycyrrhizinate enteric-coated capsule plus high-dose dexamethasone for the treatment of adults with newly-diagnosed primary immune thrombocytopenia (ITP).

NCT ID: NCT05023720 Recruiting - Clinical trials for Metastatic Colorectal Cancer

Real-World Effectiveness of Regorafenib in the Treatment of Patients With Metastatic Colorectal Cancer

Start date: July 20, 2021
Phase:
Study type: Observational

Real-World Effectiveness of Regorafenib in the Treatment of Patients with Metastatic Colorectal Cancer- A Retrospective, Observational Study

NCT ID: NCT05023707 Recruiting - Clinical trials for Acute Myeloid Leukemia

Anti-FLT3 CAR T-cell Therapy in FLT3 Positive Relapsed/Refractory Acute Myeloid Leukemia

Start date: December 31, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

This is a prospective,open-label, phase1/2 study to evaluate the safety and efficacy of anti-FLT3 chimeric antigen receptor engineered T cell immunotherapy (CART) in the treatment of FLT3 positive relapsed or refractory acute myeloid leukemia.

NCT ID: NCT05023668 Recruiting - Dermatitis, Atopic Clinical Trials

China Atopic Dermatitis Registry Study

Start date: July 28, 2021
Phase:
Study type: Observational [Patient Registry]

This regestry study is aimed to characterize the medical care and drug treatment under real-life conditions among Chinese patients with moderate to severe Atopic Dermatitis who are not well controlled by topical therapies.

NCT ID: NCT05023577 Recruiting - Clinical trials for Helicobacter Pylori Infection

Antibiotic Combination for H. Pylori Eradication in Penicillin-allergic Patients

Start date: August 26, 2021
Phase: Phase 4
Study type: Interventional

This randomized controlled clinical trial will compare the eradication efficacy of bismuth quadruple therapy containing clarithromycin+metronidazole, clarithromycin+levofloxacin, or metronidazole+levofloxacin for Helicobacter pylori first-line treatment in penicillin-allergic patients. The completion of this trial will expand new therapy for the treatment of Helicobacter pylori, which can not only ensure clinical efficacy, but also reduce the use of antibiotics.

NCT ID: NCT05023564 Recruiting - Dementia Clinical Trials

PUMCH Dementia Longitudinal Cohort Study

Start date: December 1, 2020
Phase:
Study type: Observational

The PUMCH Dementia Cohort is a hospital-based, observational study of Chinese elderly with cognitive impairment.

NCT ID: NCT05022654 Recruiting - Clinical trials for Esophageal Squamous Cell Carcinomas

SI-B001 Combined With Irinotecan in the Treatment of Recurrent Metastatic Esophageal Squamous Cell Carcinoma.

Start date: December 13, 2021
Phase: Phase 2
Study type: Interventional

This multi-center, open label Phase II clinical study is performed in patients with relapsed and metastatic esophageal squamous cell carcinoma progressed on prior PD-1/L1 antibody with or without chemotherapy. This study is investigating the safety and efficacy of SI-B001 at optimal combination dose with irinotecan in patients.

NCT ID: NCT05022030 Recruiting - Colo-rectal Cancer Clinical Trials

First-line mCapOX+Cetuximab vs. mFOLFOX6+Cetuximab for Metastatic Left-sided CRC With Wild-type RAS/BRAF Genes

CAPCET
Start date: July 21, 2021
Phase: Phase 2
Study type: Interventional

This prospective, randomized, phase 2 study is conducted to evaluate the efficacy and safety of first line mCapOX plus cetuximab versus mFOLFOX6 plus cetuximab for metastatic left-sided CRC patients with wild-type RAS and BRAF genes.

NCT ID: NCT05021835 Recruiting - Inflammation Clinical Trials

ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation

ZEUS
Start date: August 30, 2021
Phase: Phase 3
Study type: Interventional

This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). This is known as the study medicine. Which treatment participants get is decided by chance. Participants chance of getting ziltivekimab or placebo is the same. Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine doctors cannot prescribe. Participants will get the study medicine in a pre filled syringe. Participants will need to use the pre filled syringe to inject the study medicine into a skinfold once-monthly. The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have blood and urine samples taken at most of the clinic visits. Participants will have their heart examined using sound waves (echocardiography) and electrodes (electrocardiogram). Women cannot take part if pregnant, breast-feeding or planning to get pregnant during the study period.