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NCT ID: NCT05029973 Recruiting - Clinical trials for Hepatocellular Carcinoma

HAIC Combined With Sintilimab and Bevacizumab Biosimilar for Unresectable HCC

Start date: May 10, 2021
Phase: Phase 2
Study type: Interventional

To Evaluate the Efficacy and Safety of the Hepatic Arterial Infusion Chemotherapy(HAIC) Combined With Sintilimab and Bevacizumab Biosimilar in the Treatment of Patients With Unresectable Hepatocellular Carcinoma.

NCT ID: NCT05029102 Recruiting - Gastric Cancer Clinical Trials

TAS-102 and Anlotinib in ≥3 Lines mGC

Start date: September 1, 2021
Phase: Phase 2
Study type: Interventional

To determine the efficacy and safety of TAS-102 and Anlotinib in patients with metastatic gastric cancer who had been treated with ≥ 2 lines of prior standard chemotherapy

NCT ID: NCT05028985 Recruiting - Clinical trials for Obstructive Pulmonary Disease

Early COPD for China Pulmonary Health Study Stage II

EC-CPHS
Start date: January 1, 2021
Phase:
Study type: Observational

Discovery of the pathogenesis and targets in the progression of early chronic obstructive pulmonary disease

NCT ID: NCT05028933 Recruiting - Clinical trials for Advanced Hepatocellular Carcinoma

IMC001 for Clinical Research on Advanced Digestive System Malignancies

Start date: September 30, 2021
Phase: Phase 1
Study type: Interventional

A Phase I Clinical Study of Autologous T cells modified with chimeric antigen receptor targeting EpCAM ( EPCAM CAR-T) in Patients with malignant tumors of the digestive system (including advanced gastric cancer, colorectal cancer, liver cancer and pancreatic cancer) .

NCT ID: NCT05028868 Recruiting - Ischemic Stroke Clinical Trials

Clinical Research of Intravenous Thrombolysis for Ischemic Stroke in Northeast of China

CRISTINA
Start date: June 1, 2015
Phase:
Study type: Observational [Patient Registry]

This research is based on clinic treatment of intravenous thrombolysis for patients with acute ischemic stroke.By building up a database of these patients, the investigators aim to find some significance between groups by analyzing population information, clinical status and such for better evaluation and optimal treatment decision.

NCT ID: NCT05028855 Recruiting - Clinical trials for Cerebrovascular Stroke

Cerebral Autoregulation in Patients With Symptomatic Cerebral Atherosclerotic Stenosis

CASCAS
Start date: January 14, 2017
Phase:
Study type: Observational [Patient Registry]

In this multi-center prospective observational study within a cohort of symptomatic cerebral atherosclerotic stenosis (sCAS) patients, 850 subjects were planed to be enrolled to explore the relationship between cerebral autoregulation (CA) and stroke recurrence, determine the threshold values of CA parameter for predicting stroke recurrence associated with particular stenosis.

NCT ID: NCT05028504 Recruiting - Clinical trials for Gynecological Cancer

A Phase II Study of Anlotinib Combined With Penpulimab in Subjects With Gynecological Cancer

ALTER-GO-020
Start date: May 10, 2022
Phase: Phase 2
Study type: Interventional

This is a single-arm, open-label, phase II clinical trial to evaluate the efficacy and safety of penpulimab combined with anlotinib in subjects with gynecological cancer, including 23 ovarian cancer,37 endometrial cancer,26 cervical cancer.

NCT ID: NCT05028231 Recruiting - Clinical trials for Esophageal Squamous Cell Carcinoma

Neoadjuvant Immunotherapy (PD-1 / PD-L1) Combined With Chemotherapy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma: a Single Center, Prospective, Open, One Arm Exploratory Clinical Study

NICCE
Start date: June 5, 2021
Phase:
Study type: Observational

To purpose of this study is to access the safety and efficacy of neoadjuvant Immunotherapy (PD-1 / PD-L1) combined with chemotherapy for locally advanced thoracic esophageal squamous cellcarcinoma.

NCT ID: NCT05028218 Recruiting - Advanced Cancer Clinical Trials

A Clinical Study of TQB3824 in Subjects With Advanced Cancer

Start date: August 31, 2021
Phase: Phase 1
Study type: Interventional

TQB3824 blocks function of a specific protein called Cell Division Cycle 7 (CDC7) kinase in the human body, which plays important roles in the maintenance of DNA replication forks and DNA damage response pathways. This study will evaluate the safety, tolerability and pharmacokinetics of TQB3824.

NCT ID: NCT05028088 Recruiting - Liver Dysfunction Clinical Trials

Diaphragm Ultrasound to Evaluate the Antagonistic Effect of Sugammadex

Start date: July 1, 2021
Phase: Phase 4
Study type: Interventional

The use of muscle relaxants is an indispensable in the general anesthesia but is prone to accidents, which are often related to residual muscle relaxant. Therefore, how to timely and effectively eliminate the residual effect of muscle relaxants after surgery has become an urgent clinical problem. Rocuronium is a non-depolarizing muscle relaxant that is primarily metabolized by the liver. Patients with liver dysfunction can affect the metabolic process of rocuronium, thereby delaying the recovery of muscle relaxation. Sugammadex (SUG) is a novel specific antagonist of aminosteroid muscle relaxants, which can effectively antagonize muscle relaxants at different depths. However, whether liver dysfunction affects the antagonistic effect of SUG against rocuronium has not been reported yet. Therefore, the investigators hypothesize that with the increase of patients' liver Child-Pugh grade, the recovery time of rocuronium antagonized by the same dose of SUG after surgery will be prolonged, and the incidence of muscle relaxation residual will be increased in the short term.