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NCT ID: NCT05704166 Recruiting - Acute Lung Injury Clinical Trials

PirfenidoneVsPlacebo as Prophylaxis Against Acute Radiation-induced Lung Injury Following HFRT in Breast Cancer Patients

Start date: March 16, 2023
Phase: Phase 2
Study type: Interventional

The incidence of chest CT manifestations of lung injury after radiotherapy for breast cancer is more than 50%. Although the prognosis and quality of life of patients are rarely affected, it is still necessary to prevent the occurrence of minor radiation lung injury with the use of more novel drugs and subsequent salvage treatment may aggravate the radiation injury. This study intends to conduct a randomized, double-blind, single-center clinical study of pirfenidone versus placebo in the prevention of acute radiation induced lung injury after breast cancer surgery

NCT ID: NCT05704127 Recruiting - Low Back Pain Clinical Trials

Intelligent Moxibustion Robot in the Treatment of Low Back Pain

Start date: December 15, 2022
Phase: N/A
Study type: Interventional

The intelligent moxibustion robot is applied to the clinical treatment of low back pain to verify its effectiveness and safety

NCT ID: NCT05703841 Completed - Healthy Clinical Trials

A Study of JNJ-77242113 Following Oral Administration in Healthy Chinese Adult Participants

Start date: February 14, 2023
Phase: Phase 1
Study type: Interventional

The purpose of the study is to assess what drug does to body when healthy Chinese participants receive single oral dose of JNJ-77242113.

NCT ID: NCT05703750 Recruiting - Clinical trials for Hepatocellular Carcinoma

Impact of Clinical Evident Portal Hypertension on HCC With TACE (CHANCE-CHESS 2301)

Start date: May 4, 2023
Phase:
Study type: Observational

The purpose of this study is to discuss the prognostic value of CEPH among HCC patients underwent TACE treatment, its impact on overall survival, and try to stratify patient cohorts for a better treatment strategy.

NCT ID: NCT05703581 Recruiting - Pancreatic Cancer Clinical Trials

Application of "Heidelberg Triangle" Dissection in Pancreatoduodenectomy and Distal Pancreatectomy

Start date: March 1, 2023
Phase:
Study type: Observational

Aim of the study : To evaluate the effect and safety of "Heidelberg Triangle" dissection (TRIANGLE operation) combined with Pancreatoduodenectomy or Distal Pancreatectomy on the prognosis of pancreatic cancer and periampullary cancer . Methods : Patients who underwent pancreatoduodenectomy or Distal Pancreatectomy between 01 September 2016 and 30 December 2022 will be included in this retrospective analysis. 3D reconstruction is performed with preoperative enhanced CT, then the region of "Heidelberg Triangle" is categorized . The operation is completed by the same operation team. According to the operation mode, patients were divided into TRIANGLE group and non-TRIANGLE group and And followed up until recurrence, death or missed.

NCT ID: NCT05703477 Completed - Clinical trials for Clostridium Difficile Infection

The Dynamic Fluctuation of Donor Microbiota Affects the Prognosis of Fecal Microbiota Transplantation for C. Difficile Infection

Start date: January 1, 2020
Phase: N/A
Study type: Interventional

Fecal microbiota transplantation (FMT) achieves the purpose of treating intestinal and extra-intestinal diseases by transplanting the functional microbes in the feces of healthy people into the patient's intestine through the upper or lower alimentary tract routes to rebuild the patient's intestinal microbiota. Recently, FMT has been widely used in the treatment of various gastrointestinal diseases, including but not limit in CDI. In this study, we focused on the demonstration of FMT action mechanism in CDI treatment.

NCT ID: NCT05703204 Not yet recruiting - Clinical trials for Acute Myeloid Leukemia and Myelodysplastic Syndrome

A Study of QLF32101 in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome

Start date: February 1, 2023
Phase: Phase 1
Study type: Interventional

This study aimed to evaluate the safety,tolerability and preliminary efficacy of QLF32101 administered intravenously and subcutaneously in patients with R/R, AML.

NCT ID: NCT05703191 Recruiting - Clinical trials for Pulmonary Hypertension of Newborn

A Real-world Study of Nitric Oxide Generator and Delivery System

Start date: February 3, 2023
Phase:
Study type: Observational

The study is aimed to observe the efficacy and safety of Nitric Oxide Generator and Delivery System in Pulmonary Hypertension of Newborn in real clinical settings.

NCT ID: NCT05702905 Recruiting - Semaglutide Clinical Trials

Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome

Start date: May 9, 2023
Phase: Phase 4
Study type: Interventional

To investigate the efficacy of semaglutide in obese infertile women of childbearing age with polycystic ovary syndrome (PCOS), we design this prospective, randomized, open and controlled study. 75 obese infertile PCOS patients will be recruited and randomized into three groups: metformin, semaglutide and metformin+semaglutide, on the basis of calorie-restricted diet and physical exercise. All subjects will be treated for 12 weeks, and then stop taking the drug for at least 8 weeks to initiate ovulation induction or ovulation induction combined with artificial insemination. All subjects will be followed up for 24 weeks for pregnancy outcome. The primary endpoint of the study is the percentage of weight loss at 12 weeks of treatment. The secondary endpoints include HOMA-IR and androgen levels at 12 weeks of treatment, ovulation rate at 24 weeks of follow-up, clinical pregnancy rate and cumulative pregnancy rate, and depression, anxiety, diet and quality of life scores at 12 weeks of treatment.

NCT ID: NCT05702489 Recruiting - Influenza, Human Clinical Trials

A Study to Evaluate the Efficacy and Safety of ZX-7101A Tablets in Adults With Uncomplicated Influenza

Start date: September 17, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

The goal of this clinical trial is to compare ZX-7101A in Chinese Adults patients with uncomplicated influenza. The main questions it aims to answer are: - The efficacy of ZX-7101A in Chinese Adults patients with uncomplicated influenza. - The safety of ZX-7101A in Chinese Adults patients with uncomplicated influenza.