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NCT ID: NCT05822804 Not yet recruiting - Hemostasis Clinical Trials

Safety and Efficacy of the Vascular Closure Device (Tonbridge) in Hemostasis Treatment of Femoral Artery Puncture

Start date: April 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to verify the safety and efficacy of the Vascular Closure Device (Tonbridge) in hemostasis treatment for femoral artery puncture.

NCT ID: NCT05822739 Not yet recruiting - Parkinson's Disease Clinical Trials

Safety and Efficacy Study of Parkinson's Disease Gene Therapy Drug (BBM-P002)

Start date: April 28, 2023
Phase: Early Phase 1
Study type: Interventional

Safety and Efficacy Study of BBM-P002 in subjects with primary advanced Parkinson's disease

NCT ID: NCT05822726 Recruiting - Prostate Cancer Clinical Trials

The Combination of PSMA-PET/MR and p2PSA in Early Diagnosis of Prostate Cancer

Start date: October 1, 2022
Phase: N/A
Study type: Interventional

This is a single center prospective non-randomized controlled study. The goal of this clinical trial is to figure out whether the combination of PSMA-PET/MR and PHI could add values to each method alone. The main questions it aims to answer are: - Compare the diagnostic value of the combination with each alone and set up a diagnostic model. - Compare the diagnostic value of PSMA-PET/MR+PHI to mpMRI+PHI. - Evaluate the diagnostic value the combination of PHI and PSMA-PET/MR in suspected PCA patients. Patients will experience mpMRI or PSMA-PET/MR and their blood samples will be used to test PSA and p2PSA. Prostate biopsy will be the golden standard.

NCT ID: NCT05822635 Recruiting - Pancreatic Diseases Clinical Trials

SpyGlass Surgical Study

Start date: December 1, 2023
Phase:
Study type: Observational

- To document the clinical utility of diagnostic and/or therapeutic intraoperative endoscopy using a thin, single-use, flexible cholangiopancreatoscope - To identify specific surgical procedures in which intraoperative use of a thin, single use, flexible cholangiopancreatoscope suggests clinically meaningful benefit and generate a hypothesis for possible subsequent claims-supportive study

NCT ID: NCT05822453 Not yet recruiting - Clinical trials for Biliary Tract Carcinoma

Gemcitabine Plus S1 and Tislelizumab in the First Line Therapy of Advanced Biliary Tract Carcinoma

Start date: April 30, 2023
Phase: Phase 2
Study type: Interventional

This study will evaluate the efficacy and safety of 1st line therapy with gemcitabine plus S1 and tislelizumab in participants with advanced biliary tract carcinoma (BTC).

NCT ID: NCT05822284 Not yet recruiting - Clinical trials for Non-small Cell Lung Cancer

ctDNA-MRD in Stage IIIB-C NSCLC Patients Treated With Induction Chemoimmunotherapy

Start date: April 2023
Phase:
Study type: Observational

The goal of this observational study is to explore whether ctDNA-MRD dynamic monitoring can more effectively predict the therapeutic effect of induction chemoimmunotherapy followed by surgery or non-surgical treatment for stage IIIB-C driver-negative NSCLC in the MDT model, so as to accurately guide clinical diagnosis and treatment.

NCT ID: NCT05822050 Recruiting - Clinical trials for PTCL Patients Who Achieved Complete Response From Frontline Treatment

An Open, Single Center, Non-randomized, Single Arm Clinical Study of Evaluating the Efficacy of Selinexor in the Maintenance Treatment of PTCL

Start date: June 1, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

To evaluate the efficacy and safety of Selinexor maintenance therapy in PTCL patients who achieved complete response from frontline treatment, and to analyze the relationship between gene mutation in PTCL and disease prognosis and clinical features by using Next-generation sequencing (NGS) detection.

NCT ID: NCT05822037 Recruiting - Multiple Myeloma Clinical Trials

CT0594CP CAR-T Cells in Patients With Relapsed/Refractory Multiple Myeloma or Plasma Cell Leukemia

Start date: April 12, 2023
Phase: N/A
Study type: Interventional

This is an open-label, single arm study to evaluate the safety and tolerability of treatment with CT0594CP CAR-T Cells in patients with relapsed and/or refractory multiple myeloma or Plasma Cell Leukemia

NCT ID: NCT05821933 Recruiting - NSCLC Clinical Trials

RC108 Combine With Furmonertinib With/Without Toripalimab in Patients With EGFR-mutated NSCLC

Start date: September 7, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

an open, single-arm, multicenter phase Ib/II study

NCT ID: NCT05821855 Recruiting - Open-angle Glaucoma Clinical Trials

A Study to Evaluate Adverse Events and Change in Disease Activity With the XEN45 Glaucoma Treatment System Implantation In Adult Participants With Open-Angle Glaucoma in China

Start date: December 8, 2023
Phase: Phase 4
Study type: Interventional

Glaucoma is the second most common cause of blindness in the world, second only to cataracts. The purpose of this study is to assess adverse events (AEs) and changes in disease activity in participants with open-angle glaucoma (OAG) receiving the XEN45 Glaucoma Treatment System (XEN45). XEN45 is an approved device for the treatment of OAG in participants in China who have not achieved satisfactory effectiveness with or are not suitable for intraocular pressure (IOP)-lowering medication, laser surgery, or are not tolerant of traditional filtration surgery. Adult participants with a diagnosis of OAG will be randomized to receive either XEN 45 or trabeculectomy. Around 130 participants will be enrolled in the study at approximately 15 sites in China. Participants will receive XEN45 implanted using the ab interno approach or trabeculectomy on Day 1 and will be followed for 60 months An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation participant administered a pharmaceutical product which does not necessarily have a causal relationship with this treatment.