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NCT ID: NCT05837052 Recruiting - Clinical trials for Unresectable Lung Non-Small Cell Carcinoma

A Phase II Trial to Evaluate the Efficiency and Safety of Serplulimab Plus Chemotherapy as Conversion Therapy in NSCLC

Start date: May 15, 2023
Phase: Phase 2
Study type: Interventional

This is a phase II, single-arm study to evaluate the efficacy and safety of Serplulimab plus chemotherapy as conversion treatment in patients with stage IIIB-IVA oligometastatic non-small cell lung cancer.

NCT ID: NCT05836948 Not yet recruiting - Clinical trials for Advanced Solid Tumor

The Clinical Study of SHR-9839 for Injection in Patients With Advanced Solid Tumors

Start date: May 1, 2023
Phase: Phase 1
Study type: Interventional

This study is an open-label, phase I clinical trial of SHR-9839 in patients with advanced solid tumors. The whole study is divided into three stages: dose escalation, dose expansion and efficacy expansion.

NCT ID: NCT05836909 Enrolling by invitation - Clinical trials for Hypercholesterolemia

Regulation of Lipid Metabolism in Guangzhou Individuals With Dyslipidemia by Red Yeast Rice, Phytosterol Esters and Lycopene

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

The objective of this study is to evaluate the effect of using red yeast rice, phytosterol esters and lycopene in combination for 12 weeks on improving the glycolipid metabolism of Guangzhou individuals with dyslipidemia. Our hypothesis is that when compared with placebo, red yeast rice, phytosterol esters and lycopene together as supplements would lead to greater improvements in lipid metabolism (including lipid profiles and parameters ) in participants after 12 weeks.

NCT ID: NCT05836805 Not yet recruiting - Healthy Volunteers Clinical Trials

A Study of the Absorption, Metabolism and Excretion of [14C]XZP-3621 in Human

Start date: May 2023
Phase: Phase 1
Study type: Interventional

This non-randomized, single group, open-label study will investigate the mass balance, routes of elimination, pharmacokinetics, metabolism, safety and tolerability of a single oral dose of [14C]XZP-3621 in healthy volunteers.

NCT ID: NCT05836766 Recruiting - Clinical trials for Acute Ischemic Stroke

Cilostazol Dexborneol Versus Placebo for Microcirculation Dysfunction After Reperfusion Therapy in Patients With Acute Ischemic Stroke With Large Vessel Occlusion

CRYSTAL
Start date: June 5, 2023
Phase: Phase 2
Study type: Interventional

This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and received reperfusion therapy. Moreover, we expect to evaluate the safety of using Y-6 sublingual tablet in such study population.

NCT ID: NCT05836753 Recruiting - Clinical trials for Ischemic Stroke, Acute

Efficacy and Safety of Sarecycline in Patients With Acute Ischemic Stroke After Reperfusion Therapy

ESPRIT
Start date: May 7, 2023
Phase: Phase 2
Study type: Interventional

The aim of this study was to evaluate the efficacy and safety of Sarecycline versus placebo in the treatment of microcirculation dysfunction after reperfusion therapy in patients with large vessel occlusion stroke.

NCT ID: NCT05836740 Recruiting - Clinical trials for Ischemic Stroke, Acute

Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke

EMPHASIS
Start date: May 19, 2023
Phase: Phase 3
Study type: Interventional

The aim of this study was to evaluate the efficacy and safety of Minocycline versus placebo in the treatment of patients with moderate to severe acute ischemic stroke.

NCT ID: NCT05836701 Recruiting - Clinical trials for Germ Cell Tumor of CNS

Retrospective Study of Germ Cell Tumors of the Central Nervous System

Start date: June 1, 2023
Phase:
Study type: Observational

Retrospectively analyzing the epidemiological and clinical characteristics, treatment, recurrence, prognosis and prognostic factors of the germ-cell tumors of central nervous system in a single center.

NCT ID: NCT05836441 Recruiting - Vitiligo Clinical Trials

Improved Phototherapy in Patients With Vitiligo

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

Vitiligo is a common acquired depigmentation skin and mucosal disease in dermatology, with or without white hair. Vitiligo with white hair is difficult to treat. Phototherapy and topical therapy are the first line treatment methods for vitiligo. The peripheral leukoplakia irradiation of phototherapy covers the central area of the leukoplakia and performs phototherapy on the edge of the leukoplakia and surrounding normal skin. This study aims to compare the efficacy and safety of peripheral leukoplakia ultraviolet family phototherapy and leukoplakia family combination in the treatment of vitiligo.

NCT ID: NCT05836194 Recruiting - Diabetes Mellitus Clinical Trials

Evaluation of Diabetic Retinopathy Using Ultra-Widefield Fundus Images Compared With Two-Field Fundus Images

Start date: February 1, 2023
Phase:
Study type: Observational

This study aims to compare the accuracy of evaluating diabetic retinopathy using ultra-widefield fundus images versus two-field fundus images. The hypothesis is that screening and grading diabetic retinopathy based on ultra-widefield fundus images may yield higher accuracy compared to the use of two-field fundus images.