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NCT ID: NCT06355258 Recruiting - Clinical trials for COVID 19 Associated Coagulopathy

A Study of the Efficacy of Troxerutin in Preventing Thrombotic Events in COVID-19 Patients

Start date: September 15, 2023
Phase: Phase 1
Study type: Interventional

The goal of this clinical trial is to learn if troxerutin works to prevent thrombotic events in mild or severe COVID-19 patients. It will also learn about the safety of troxerutin. The main questions it aims to answer are: - Does troxerutin lower the number of thrombotic events in participants? - What medical problems do participants have when taking troxerutin? Researchers will compare troxerutin to a placebo (a look-alike substance that contains no drug) to see if troxerutin works to prevent thrombotic events in COVID-19 patients. Participants will: - Take troxerutin or a placebo every day for 7 days. - Visit the clinic at the first, fourth, seventh and 28th days after enrollment for checkups and tests - Keep a diary of their symptoms and the number of times of thrombotic events, bleeding events and type II HIT-related thrombocytopenia

NCT ID: NCT06355206 Recruiting - Cohort Study Clinical Trials

Natural Course and Therapeutic Effect of Recurrent Acute Pancreatitis

NACRE
Start date: April 22, 2024
Phase:
Study type: Observational

The goal of this observational cohort study is to learn about the etiology, natural course, therapeutic effect and outcome of recurrent acute pancreatitis patients. The main question it aims to answer is: Does endoscopic intervention, surgery or conservative treatment reduce the recurrence of acute pancreatitis? What are the risk factors affecting the recurrence of acute pancreatitis? Patients will be closely followed and clinical information will be recorded.

NCT ID: NCT06355076 Recruiting - Prostate Cancer Clinical Trials

New Urethral Reconstruction in Robot-assisted Laparoscopic Radical Resection

Start date: February 5, 2023
Phase: N/A
Study type: Interventional

The purpose of this clinical trial is to compare new reconstruction and anastomosis in robot-assisted radical laparoscopic resection It will also understand the possibility of exploring new reconstruction in completely solving patients' postoperative urinary incontinence The main questions it aims to answer are: Is there a significant improvement in urinary control in patients with new reconstruction compared with patients with anastomosis? The researchers compared the new reconstruction with anastomosis in robot-assisted laparoscopic radical resection to see if the new reconstruction improved urinary incontinence after operation. Participants will: The intervention group adopted the new reconstruction proposed by our team; End-to-end anastomosis was performed in non-intervention group.

NCT ID: NCT06354595 Recruiting - Clinical trials for Colorectal Neoplasms

Feasibility Study of Multidimensional Rehabilitation in the Metaverse

Start date: March 1, 2024
Phase: N/A
Study type: Interventional

The investigators evaluated and optimized the Metaverse multi-dimensional rehabilitation platform based on the use of the Metaverse multi-dimensional rehabilitation platform by colorectal cancer survivors and their families, and finally launched the Metaverse multi-dimensional rehabilitation platform.

NCT ID: NCT06354569 Recruiting - Clinical trials for Perioperative Respiratory Adverse Events

Risk Factors and Risk Grading Prediction of Perioperative Respiratory Adverse Events in Children

Start date: December 31, 2024
Phase:
Study type: Observational

to explore the risk factors of perioperative respiratory adverse events in children, and to establish a risk prediction model of perioperative respiratory adverse events in children

NCT ID: NCT06354530 Recruiting - Clinical trials for Esophageal Squamous Cell Carcinoma

A Study of Neoadjuvant Therapy for the Treatment of Patients With Locally Advanced Esophageal Squamous Cell Carcinoma

Start date: March 8, 2024
Phase: Phase 2/Phase 3
Study type: Interventional

The goal of this interventional study is to compare the safety and efficacy of neoadjuvant immunotherapy plus chemotherapy and anlotinib versus immunotherapy combined with concurrent chemoradiotherapy in the treatment of locally advanced esophageal squamous cell carcinoma. The main question it aims to answer is: To evaluate the safety and efficacy of neoadjuvant immunotherapy plus chemotherapy and anlotinib versus immunotherapy combined with concurrent chemoradiotherapy in patients with locally advanced esophageal squamous cell carcinoma and to explore the optimal preoperative neoadjuvant treatment regimen for esophageal squamous cell carcinoma.

NCT ID: NCT06354244 Recruiting - Urinary Retention Clinical Trials

Electroacupuncture of Different Treatment Frequency in Chronic Urinary Retention Caused by Lower Motor Neuron Lesions

Start date: April 4, 2024
Phase:
Study type: Observational

The aim of this study is to compare the effects of electroacupuncture of different frequency in patients with chronic urinary retention caused by lower motor neuron lesions

NCT ID: NCT06354231 Recruiting - Renal Insufficiency Clinical Trials

DV Combined With Toripalimab for Renal Preservation in Solitary Kidney or Renal Insufficiency or Bilateral Multiple UTUC

Start date: July 20, 2023
Phase: Phase 2
Study type: Interventional

Approximately 20 participants will be enrolled in the study to evaluate the efficacy and safety of the combination of DV (DV, 2.0 mg/kg, intravenously administered every 2 weeks) and toripalimab (toripalimab, 3.0mg/kg, intravenously administered every 2 weeks). Subjects will receive 6 cycles of DV and toripalimab, followed by laser surgery to remove ureteral or renal pelvis tumors, followed by 12 cycles of DV and 1 year of toripalimab consolidation therapy. Efficacy and safety were evaluated by cystoscopy, ureteroscopy, laboratory tests, and imaging examinations after treatment.

NCT ID: NCT06354218 Recruiting - Clinical trials for Esophageal Carcinoma

Serplulimab Combined With Concurrent Chemoradiotherapy for Locally Advanced Treatment Esophageal Cancer in Old Age

Start date: December 1, 2023
Phase: Phase 2
Study type: Interventional

This study is a Single Arm, Prospective, Exploratory, Single Center Phase II Clinical Study to evaluate the effectiveness of the combination of Serplulimab and Concurrent Chemoradiotherapy in the treatment of elderly patients with locally advanced esophageal cancer who cannot be treated surgically.Subjects can be enrolled into this study only if they meet inclusion criteria and do not meet exclusion criteria.

NCT ID: NCT06354140 Recruiting - Clinical trials for Postoperative Assistance for Esophageal Squamous Cell Carcinoma With Negative Lymph Nodes

PPIO-008S-1 Combined With Tislelizumab in Patients With Primary Residual Node-negative Esophageal Squamous Cell Carcinoma (ESCC) After Radical Resection With Neoadjuvant Immunotherapy Combined With Chemotherapy, PHASE II STUDY

Start date: April 7, 2024
Phase: Phase 2
Study type: Interventional

To explore the safety and efficacy of Tegafur combined with tislelizumab in patients with esophageal squamous cell carcinoma with residual primary lesion and node-negative after radical resection following neoadjuvant immunotherapy combined with chemotherapy