Clinical Trials Logo

Filter by:
NCT ID: NCT05894486 Not yet recruiting - Clinical trials for Neuroendocrine Tumors

Phase II Study to Evaluate the Efficacy and Safety of 177Lu-Dotatate in the First-line Treatment of Patients With Locally Advanced or Metastatic, Somatostatin Receptor-positive G2 or G3 Gastroenteropancreatic Neuroendocrine Tumors

Start date: June 5, 2023
Phase: Phase 2
Study type: Interventional

his was a single-center, single-arm phase II study evaluate the efficacy and safety of Lutetium[177Lu] Oxodotreotide Injection in the first-line treatment of unresectable or metastatic, progressive, G2 or G3, somatostatin receptor positive gastroenteropancreatic neuroendocrine tumours.

NCT ID: NCT05894460 Recruiting - Clinical trials for Peripheral Arterial Disease

Constrained Balloon Combined With Drug-coated Balloon Angioplasty for Femoropopliteal Lesion

Start date: June 27, 2023
Phase:
Study type: Observational

This study will assess the safety and efficacy of Chocolate balloons as a combination with drug-coated balloons in the treatment of popliteal artery lesions in lower limb atherosclerotic occlusive disease and will compare them with conventional balloons.

NCT ID: NCT05894421 Recruiting - Advanced Cancer Clinical Trials

TQB2223 Injection in Combination With Penpulimab in Patients With Advanced Cancers

Start date: June 6, 2023
Phase: Phase 1
Study type: Interventional

TQB2223 is a recombinant, fully humanized antibody that binds lymphocyte activation gene-3 (LAG-3) and blocks the LAG-3/ major histocompatibility complex class II (MHC-II) interaction, thus allowing for increased T-cell proliferation and cytokine production. This is a phase I study to evaluate the safety, tolerability, pharmacokinetics (PK) and effectiveness of TQB2223 injection in combination with Penpulimab in subjects with advanced cancers.

NCT ID: NCT05894408 Completed - Clinical trials for Postoperative Nausea and Vomiting

Portal Vein Occlusion is a Valuable Predictor for Postoperative Nausea and Vomiting

Start date: June 15, 2023
Phase:
Study type: Observational

Postoperative nausea and vomiting (PONV) is one of the most common and distressing postoperative complications. PONV risk assessment is recommanded to determine the number of medications or strategies for prophylaxis. Many well-known risk factors have been determined. However, no study has explored liver surgery-specific risk factors. This study aims to identify whether there was an association between portal vein occlusion and PONV among patients after liver surgery. Patients diagnosed with liver cancer and undergoing hepatectomy will be prospectively consecutively recruited. All enrolled patients receive PONV assessments within the first 24 postoperative hours. Logistic regression models will be used to investigate the effects of portal vein occlusion and the other variables on the occurrence of PONV in both univariate and multivariate analyses

NCT ID: NCT05894382 Recruiting - Myopia, Progressive Clinical Trials

Double Helix Design Defocus Lens Spectacle (RACE) for Myopia Control

Start date: June 3, 2023
Phase: N/A
Study type: Interventional

This study uses 1.585 double helix defocus lens PC lenses with a unique optical design that includes a globally coherent visible area and complementary left and right helices that can form clear images. In addition, the helical arrangement and reduced slit area can generate defocusing signals, inhibiting the development of myopia. Therefore, based on previous research, this study plans to evaluate the safety and effectiveness of 1.585 double helix defocus lens PC frame eyeglasses in controlling the progression of myopia in children and adolescents through a randomized controlled clinical trial.

NCT ID: NCT05894369 Recruiting - Esophageal Cancer Clinical Trials

Influence Mechanism of Tumor Microenvironment Changes on Neoadjuvant Therapy for Esophageal Squamous Cell Carcinoma

Start date: May 4, 2023
Phase:
Study type: Observational [Patient Registry]

To evaluate the predictive value and mechanism of inflammatory factors in peripheral blood on the prognosis of patients, and to explore the influencing factors of inflammation and tumor microenvironment on the efficacy of neoadjuvant chemotherapy combined with immunotherapy for esophageal cancer. To explore the predictors of neoadjuvant therapy in patients with esophageal squamous cell carcinoma.

NCT ID: NCT05894239 Recruiting - Clinical trials for Metastatic Breast Cancer

A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

Start date: July 28, 2023
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy and safety of inavolisib in combination with Phesgo (pertuzumab, trastuzumab, and rHuPH20 injection for subcutaneous use) compared with placebo in combination with Phesgo, as maintenance therapy, after induction therapy in participants with previously untreated HER2-positive advanced breast cancer (ABC).

NCT ID: NCT05894148 Recruiting - Clinical trials for Interstitial Lung Disease

Clinical Study of Multiple Dose Genakumab for Injection in Chinese Healthy Adults

Start date: March 6, 2023
Phase: Phase 1
Study type: Interventional

To evaluate the safety and tolerability of multiple-dose subcutaneous injections of Genakumab for Injection in Chinese healthy adult volunteers.

NCT ID: NCT05894135 Recruiting - Endometriosis Clinical Trials

Efficacy and Safety of BG2109 in Chinese Subjects With Endometriosis

Start date: July 14, 2023
Phase: Phase 3
Study type: Interventional

The objective of this study is to demonstrate the efficacy and safety of BG2109 administered orally once daily at a dose of 100 mg alone or of 200 mg in combination with add-back hormone replacement therapy (ABT: estradiol (E2) 1 mg / norethisterone acetate (NETA) 0.5 mg) versus placebo, while under randomized treatment, in the management of moderate to severe endometriosis-associated pain (EAP) in chinese women with surgically confirmed endometriosis

NCT ID: NCT05894018 Recruiting - Sarcoma,Soft Tissue Clinical Trials

Brachytherapy (Iodine-125 Seeds) and Fluzoparib Combination Therapy for Advanced Unresectable Soft Tissue Sarcoma

RAFAS-001
Start date: June 29, 2023
Phase: Phase 2
Study type: Interventional

To evaluate the effectiveness and safety of radioactive particles in combination with the PARP inhibitor fluzoparib in the treatment of advanced inoperable soft tissue sarcoma.