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NCT ID: NCT05655897 Recruiting - Clinical trials for Mitral Regurgitation

Safety and Efficacy of the GeminiOne Transcatheter Valve Edge-to-Edge Repair System in Patients With Moderate-severe or Severe Degenerative Mitral Regurgitation

Start date: November 24, 2022
Phase: N/A
Study type: Interventional

To observe and evaluate the safety and efficacy of the GeminiOne Transcatheter Valve Edge-to-Edge Repair System in Patients With Moderate-severe or Severe Degenerative Mitral Regurgitation through a prospective, multicenter clinical trial using objective performance criteria.

NCT ID: NCT05655845 Recruiting - Constipation Clinical Trials

Risk Factors for Bowel Dysfunction at Preschool and Early Childhood Age in Children With Hirschsprung Disease

Start date: August 20, 2022
Phase:
Study type: Observational

Bowel dysfunction has been proven as the most common complication after pull-through(PT) of Hirschsprung disease(HD) ,which may persist to adulthood and lead to social problems.The reason of bowel dysfunction is complicated and the risk factors were not defined.

NCT ID: NCT05655676 Recruiting - Multiple Myeloma Clinical Trials

89Zr-labeled NY008 PET Imaging in Patients

Start date: May 25, 2022
Phase: Early Phase 1
Study type: Interventional

This is a single arm study to evaluate the safety and biodistribution of 89Zr-labeled NY008 PET Imaging in patients with multiple myeloma

NCT ID: NCT05655468 Recruiting - Atrial Fibrillation Clinical Trials

Effect of Prolonged Use of Dronedarone on Recurrence in Patients With Non-paroxysmal Atrial Fibrillation After Radiofrequency Ablation

DORIS
Start date: March 29, 2023
Phase: Phase 4
Study type: Interventional

Recurrence rate remains high after radiofrequency ablation in patients with non-paroxysmal atrial fibrillation(AF). Prolonged use of anti-arrhythmic drugs (AAD) beyond the post-ablation blanking has been adopted as a solution but without sufficient clinical evidence. Dronedarone is an AAD valid to maintain sinus rhythm and has fewer side effect than other AAD for long-term use.We sought to investigate the effect of prolonged use of dronedarone on recurrence of non-paroxysmal AF patients beyond the post-blanking period within the first year after ablation.

NCT ID: NCT05655429 Recruiting - Clinical trials for Knee Medial Meniscus Tears

Physical Therapy vs Arthroscopic Partial Meniscectomy

Start date: January 15, 2020
Phase: N/A
Study type: Interventional

The purpose was to assess knee function outcomes between physical therapy and arthroscopic partial menisectomy(APM) for Metabolic syndrome(MetS) patients with degenerative meniscus lesions(DMLs) during 12 month follow up.

NCT ID: NCT05654857 Recruiting - Clinical trials for Helicobacter Pylori Infection

The Prevalence of Family-unit Helicobacter Pylori Infection in Jiangsu

Start date: March 1, 2023
Phase:
Study type: Observational

To assess Family-unit Helicobacter Pylori Infection rates and antimicrobial resistance rates in Jiangsu,China

NCT ID: NCT05654623 Recruiting - Clinical trials for Advanced Breast Cancer

A Study to Learn About a New Medicine Called ARV-471 (PF-07850327) in People Who Have Advanced Metastatic Breast Cancer.

VERITAC-2
Start date: March 3, 2023
Phase: Phase 3
Study type: Interventional

A study to learn about a new medicine called ARV-471 (PF-07850327) in people who have advanced metastatic breast cancer.

NCT ID: NCT05654194 Recruiting - Clinical trials for Acute Myeloid Leukemia

Azacitidine Combined With Venetoclax and ATRA in Newly Diagnosed AML

Start date: October 31, 2022
Phase: Phase 3
Study type: Interventional

This is a single arm study to evaluate the safety and efficiency of azacitidine (AZA) combination with venetoclax and ATRA in Patients With Newly diagnosed acute myeloid leukemia. Azacitidine, venetoclax and ATRA, may stop the growth of cancer cells, either by demethylation, by promoting cells differentiation or by killing the cells.

NCT ID: NCT05654077 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

EBV CAR-T Cells for Nasopharyngeal Carcinoma

Start date: January 18, 2022
Phase: Early Phase 1
Study type: Interventional

The aim of this study is to investigate the safety and preliminary efficacy of EBV CAR-T cells in the treatment of relapsed/refractory NPC

NCT ID: NCT05654038 Recruiting - Clinical trials for B-Cell Lymphoblastic Leukemia/Lymphoma

A Study of Universal CD19-Targeted UCAR-NK Cells Combined With HSCT for B Cell Hematologic Malignancies

Start date: December 8, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

It is a single-center, open-labeled, single-arm, non-randomized investigator-initiated trial evaluating the efficacy and safety of anti-CD19 universal CAR-NK(UCAR-NK) cells therapy combined with HSCT for B cell hematologic malignancies.