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NCT ID: NCT05995418 Active, not recruiting - Alzheimer Disease Clinical Trials

Study on the Health Economic Burden of Alzheimer's Disease in China

Start date: July 1, 2023
Phase:
Study type: Observational

This study is a multi-center and cross-sectional study. Using standardized case report forms, we randomly selected suitable patients from the cognitive centers of provincial administrative units in Chinese mainland to conduct a questionnaire survey, so as to obtain relevant information about their economic burden.

NCT ID: NCT05995327 Recruiting - Spine Deformity Clinical Trials

Reasons and Risk Factors for Unplanned Spinal Re-operation

Start date: January 1, 2012
Phase:
Study type: Observational

Unplanned re-operation is one of the common negative indicators reflecting the quality and safety of surgery in the medical industry and has become one of the ten goals for the improvement of national medical quality and safety in China since 2022, while about 40% of unplanned re-operations in Peking University Third Hospital in recent years occur in spine patients of the orthopedics department. This project intends to establish a high-quality and sustainable ambispective disease cohort for spine surgery in Peking University Third Hospital based on the unplanned re-operations that occurred in the Orthopedics Department of Peking University Third Hospital from January 2012 to December 2025. The investigators further summarize and analyze clinical causes and risk factors of re-operations, aiming to explore scientific coping strategies and provide reference for continuous improvement of medical service quality.

NCT ID: NCT05995093 Recruiting - Clinical trials for Disseminated Intravascular Coagulation

The Proactive Diagnostic Value of Hemostatic Biomarkers in Disseminated Intravascular Coagulation

Start date: December 1, 2022
Phase:
Study type: Observational

The project was undertaking by Qilu Hospital of Shandong University, aiming to evaluate diagnostic performance of hemostatic biomarkers in disseminated intravascular coagulation.

NCT ID: NCT05995054 Recruiting - Clinical trials for Immune Thrombocytopenia

A Prospective, One-arm and Open Clinical Study of Obinutuzumab in the Treatment of Immune Thrombocytopenia

2023CD20ITP
Start date: August 28, 2023
Phase: Phase 2
Study type: Interventional

To evaluate the safety and efficacy of Obinutuzumab in the treatment of immune thrombocytopenia in patients who have not responded adequately or relapsed after first-line treatment.

NCT ID: NCT05995041 Recruiting - Clinical trials for Acute Myeloid Leukemia

Universal CAR-T Cells Targeting AML

Start date: October 31, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this clinical trial is to assess the feasibility, safety and efficacy of universal CAR T-cell products targeting CLL-1, CD33, CD38 and CD123 in patients with relapsed and refractory AML. The study also aims to learn more about the function of the universal CAR T cells and their persistency in AML patients.

NCT ID: NCT05995028 Recruiting - Clinical trials for Acute Myeloid Leukemia

Universal 4SCAR7U Targeting CD7-positive Malignancies

Start date: October 31, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this clinical trial is to assess the feasibility, safety and efficacy of universal CAR T cells based on 4SCAR7U design against CD7-positive hematological malignancies using CD7 specific universal CAR T cells. The study also aims to learn more about the function of CD7 targeting CAR T cells and their persistence in patients of hematological malignancies.

NCT ID: NCT05995015 Recruiting - B Cell Malignancies Clinical Trials

4SCAR19U T Cells Targeting B Cell Malignancies

Start date: October 31, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the feasibility, safety and efficacy of universal CAR T cell therapy against CD19-positive hematological malignancies using a novel CD19-specific CAR T cell product, 4SCAR19U T cells. The study also aims to learn more about the function of the 4SCAR19U T cells and their persistence in patients. This is a phase I trial enrolling patients from multiple clinical centers.

NCT ID: NCT05994898 Recruiting - Ultrasound Clinical Trials

Ultrahigh-frequency Ultrasonography (UHFUS) in Detection of Small Pulmonary Ground Glass Opacity (GGO)

UHFUSGGO
Start date: January 4, 2023
Phase:
Study type: Observational

The purpose of this study is to assess the feasibility of UHFUS on detection of GGOs in excised lung tissue and investigate UHFUS features of GGO in vitro. Each GGO was detected by palpation, UHFUS and open biopsy in sequence. The comparison of detection rate and time consumption were analyzed respectively. The Bland-Altman analysis was used to estimate the agreement of tumor size measured by CT, UHFUS and pathology.

NCT ID: NCT05994872 Not yet recruiting - Clinical trials for Anterior Cruciate Ligament Injuries

Reverse Drilling Technique in Improving Outcomes After Arthroscopic Anterior Cruciate Ligament Reconstruction

Start date: May 31, 2024
Phase: N/A
Study type: Interventional

Anterior cruciate ligament (ACL) injuries and bone tunnel enlargement (BTE) after ACL reconstruction (ACLR) remain frequent issues. Bone dust (BD) produced by tunnel preparation with osteogenic ability and reverse drilling (RD), an easy compaction technique, make it accessible to enhance tendon-bone healing in ACLR. We hyposize that RD and BD synergistically improve outcomes after arthroscopic ACLR by improving peritunnel bone and preventing BTE.

NCT ID: NCT05994859 Recruiting - Clinical trials for Hepatocellular Carcinoma

SIRT for Potentially Resectable HCC

Start date: August 10, 2023
Phase: N/A
Study type: Interventional

This study is conducted to evaluate the efficacy and safety of Y-90 selective internal radiation therapy (SIRT) in patients with potentially resectable hepatocellular carcinoma (HCC).