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NCT ID: NCT05976906 Recruiting - Clinical trials for Advanced Solid Tumors

Universal Dual-target NKG2D-NKp44 CAR-T Cells in Advanced Solid Tumors

Start date: May 23, 2023
Phase: Phase 1
Study type: Interventional

This is a single arm, open-label, multi-center, phase I study to evaluate the safety, tolerability, preliminary efficacy, pharmacodynamics and immunogenicity of universal chimeric natural killer receptor modified T-cells (CNK-UT) targeting NKG2D-Ligands and NCR2-Ligands with or without lymphodepletion in advanced solid tumors.

NCT ID: NCT05976620 Recruiting - Breast Tumors Clinical Trials

Clinical Study of 18F-FAPI-RGD in Breast Tumors

Start date: June 20, 2023
Phase:
Study type: Observational [Patient Registry]

The goal of this observational study is to learn about the value of 18F-FAPI-RGD PET/CT imaging in Breast Tumors. Participants will undergo clinical evaluation and 18F-FAPI-RGD PET/CT examination.

NCT ID: NCT05976607 Recruiting - Renal Tumor Clinical Trials

Clinical Study of 18F -FAPI-RGD in Renal Tumor

Start date: June 20, 2023
Phase:
Study type: Observational [Patient Registry]

The goal of this observational study is to learn about the value of 18F-FAPI-RGD PET/CT imaging in Renal Tumor. Participants will undergo clinical evaluation and 18F-FAPI-RGD PET/CT examination.

NCT ID: NCT05976594 Recruiting - Hepatitis E Clinical Trials

Long-term Effectiveness of a Recombinant Hepatitis E Vaccine

Start date: August 12, 2023
Phase:
Study type: Observational

This test-negative study is designed to evaluate the long-term effectiveness of hepatitis E vaccine (Hecolin®) and to explore the prevalence of rat hepatitis E in Dongtai City.

NCT ID: NCT05976529 Recruiting - Endometriosis Clinical Trials

A Multicenter, Observational Clinical Study of Dydrogesterone

Start date: January 1, 2023
Phase:
Study type: Observational

The objective of this study was to investigate the efficacy and safety of dydrogesterone in the long-term management of ovarian endometriosis cyst after surgery.

NCT ID: NCT05976516 Recruiting - Cytokine Clinical Trials

CXCL2/CXCL8 Promote Intervertebral Disc Degeneration

Start date: August 1, 2023
Phase:
Study type: Observational

Low back pain (LBP) is the largest cause of morbidity in the world, and about 80% of Chinese people are affected in their lifetime. Although the prevalence of IDD gradually increases with age, IDD is very common among subjects under 30 years old. In addition to age, there are other factors, such as excessive or uneven mechanical load, obesity, genetics, nutrition, trauma and gender. In addition, it is not clear whether the heavy physical load associated with occupation is an important risk factor for IDD. Some studies have found that IDD is more common among athletes than the general population. Due to the complexity and multifactorial nature of IDD, its pathogenesis and risk factors are still unclear, which seriously hinders the rational stratification of LBP patients and limits the development of personalized treatment.

NCT ID: NCT05976412 Recruiting - Breast Cancer Clinical Trials

Regional Lymph Node Irradiation for High-risk pN0 Breast Cancer

Start date: July 28, 2023
Phase: N/A
Study type: Interventional

This study is a non blind, randomized controlled study, whose hypothesis was that chest wall/whole breast combined regional lymph node radiotherapy can improve the 5-year disease-free survival rate of clinical high-risk pN0 breast cancer patients.

NCT ID: NCT05976308 Recruiting - Clinical trials for Polycystic Ovary Syndrome

Efficacy of Bushen Huatan Decoction in the Treatment of Polycystic Ovary Syndrome

Start date: September 1, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

Polycystic ovary syndrome (PCOS) is a common reproductive disease associated with endocrine and metabolic disorders. Some studies have shown that Chinese herbal medicine is beneficial for PCOS, but the efficacy of Chinese herbal medicine in the treatment of PCOS is not clear, because the quantity of pre-clinical data was limited and the quality of clinical evidence was variable. Therefore, this randomized double-blind placebo-controlled trial aim to evaluate the efficacy of Chinese herbal medicine (Bushen Huatan Decoction) in women with PCOS.

NCT ID: NCT05976295 Recruiting - Clinical trials for Polycystic Ovary Syndrome

Efficacy of Jianpi Qushi Huatan Decoction in the Treatment of Polycystic Ovary Syndrome

Start date: August 31, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

Polycystic ovary syndrome (PCOS) is a common reproductive disease associated with endocrine and metabolic disorders. Some studies have shown that Chinese herbal medicine is beneficial for PCOS, but the efficacy of Chinese herbal medicine in the treatment of PCOS is not clear, because the quantity of pre-clinical data was limited and the quality of clinical evidence was variable. Therefore, this randomized double-blind placebo-controlled trial aim to evaluate the efficacy of Chinese herbal medicine (Jianpi Qushi Huatan Decoction) in women with PCOS.

NCT ID: NCT05976243 Recruiting - Clinical trials for Chronic Inducible Urticaria

A Study to Investigate Efficacy, Safety, and Tolerability of Remibrutinib Compared With Placebo in Adults With CINDU Inadequately Controlled by H1-antihistamines

Start date: December 7, 2023
Phase: Phase 3
Study type: Interventional

This is a Phase 3, parallel group, placebo-controlled, double-blind, confirmatory study in patients with CINDU, with an optional Open-label Extension (OLE). The purpose of the core period (52 weeks of treatment) of this study is to evaluate the efficacy, safety, and tolerability of remibrutinib (LOU064) vs. placebo in adults suffering from CINDU inadequately controlled by H1-antihistamines (H1-AHs). The purpose of the OLE period is to collect long-term efficacy, safety, and tolerability data on remibrutinib in participants after having completed the Core period