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NCT ID: NCT05666830 Completed - Wounds and Injuries Clinical Trials

One-step Application of Artificial Dermis

Start date: January 28, 2021
Phase:
Study type: Observational

The goal of this observational study is to study the effectiveness of one-step application of Lando® artificial dermal regeneration matrix for burn and plastic wound repair. The main question it aims to answer is: the effectiveness of one-step application of Lando® artificial dermal regeneration matrix, including the take rate of skin graft and the appearance recovery of the wound. Participants will be treated with artificial dermis that perfomed with STSG simultaneously. According to the routine clinical practice, the take rate of split-thickness skin graft at about 2-3 weeks and the appearance recovery of the wound at 3 months and 6 months after the implantation were measured.

NCT ID: NCT05665647 Completed - Healthy Volunteers Clinical Trials

Drug-Drug Interaction Study of Itraconazole, Rifampicin and Midazolam With SIM0417/Ritonavir in Healthy Participants

Start date: December 29, 2022
Phase: Phase 1
Study type: Interventional

This is a phase 1, open-label, fixed-sequence, 2-period drug-drug interaction study to evaluate the pharmacokinetic interactions of itraconazole, rifampicin, midazolam, and SIM0417/ritonavir in healthy Chinese subjects.

NCT ID: NCT05664750 Completed - Tetanus Clinical Trials

Study to Compare the Efficacy and Safety of Passive Immunization With TNM002 Injection and Human Tetanus Immunoglobulin as Prophylaxis Against Tetanus

Start date: December 22, 2022
Phase: Phase 3
Study type: Interventional

TNM002 Injection is a recombinant fully human native monoclonal antibody (mAb) against tetanus toxin and is currently under development for indication of prophylaxis against tetanus.

NCT ID: NCT05663593 Completed - Healthy Volunteers Clinical Trials

Safety, Tolerability,PK/PD, Food Effect of Single and Multiple Ascending Doses of HSK31858 in Healthy Volunteers

Start date: February 23, 2022
Phase: Phase 1
Study type: Interventional

This is a phase I, randomised, double-blind placebo-controlled, 2-part study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and food effect of single and multiple oral doses of HSK31858 in healthy volunteers

NCT ID: NCT05663021 Completed - Breast Cancer Clinical Trials

Feasibility in Identification of Breast Cancer Candidates for Elimination of Axillary Surgery

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

Preoperative identification of patients with pathologic complete response or residual disease in axilla can aid in tailoring subsequent axillary surgery including omission of axillary surgery based on tumor biology and response to neoadjuvant chemotherapy.

NCT ID: NCT05661838 Completed - Spinal Fusion Clinical Trials

Effect of Intraoperative Allogeneic Blood Transfusion on Postoperative Pulmonary Complications

Start date: August 1, 2013
Phase:
Study type: Observational

Elective spine surgery is associated with a high incidence of perioperative complications, including peri- and postoperative pulmonary complications (PPCs), which occur in nearly 4% of patients. More than 40% of all deaths after elective spine surgery are attributed to PPCs. However, whether it influences risk of other PPCs is unclear.

NCT ID: NCT05661591 Completed - Malignant Tumor Clinical Trials

Effect of Fluconazole on Pharmacokinetics of SHR2554 in Healthy Subjects

Start date: February 28, 2023
Phase: Phase 1
Study type: Interventional

The study is being conduct to evaluate fluconazole effect of on SHR2554 in condition of single-canter, open-label, single-dose in healthy subjects. To explore the SHR2554 pharmacokinetics change under use of fluconazole and insure the safety with SHR2554 combined with fluconazole.

NCT ID: NCT05659654 Completed - COVID-19 Clinical Trials

The Application of Ursodeoxycholic Acid for the Prevention of SARS-CoV-2 Infection (COVID-19)

Start date: December 16, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

Evaluation of the efficacy and safety of ursodeoxycholic acid in blocking the transmission of infectious novel coronaviruses in a population of medical workers

NCT ID: NCT05659602 Completed - Clinical trials for Coronavirus Disease 2019(COVID-19)

A Clinical Study to Assess Preliminary Efficacy, Safety and Tolerability of HH-120 Nasal Spray in COVID-19 Patients

Start date: July 9, 2022
Phase: N/A
Study type: Interventional

To evaluate the preliminary efficacy and safety of HH-120 nasal spray in the treatment of asymptomatic or mild COVID-19.

NCT ID: NCT05659095 Completed - Clinical trials for Hair Transplantation

Autologous Hair Follicle Derived Mesenchymal Stem Cell Suspension to Treat AGA

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

Androgenic alopecia (AGA) is characterized by progressive hair follicle miniaturization, and novel treatments are needed to intervene in the miniaturization process. The investigators aimed to evaluate the efficacy, safety, effectiveness, and effective population of autologous hair follicle mesenchymal stem cell therapy for the treatment of advanced AGA in Chinese people. 50 participants ranging from 25 to 45 years old, with an average age of 32 ± 1.24 years were included. None of them had ever used minoxidil, finasteride, or other drugs to promote hair growth. Healthy hair follicles were extracted from the occipital area and treated to obtain hair follicle mesenchymal stem cells suspensions. The recipient sites were divided into two groups. Nine points were injected in a 1 cm2 area, and 100 μl of solution containing either 1 × 105 cells or normal saline was injected at each point. The follow-up duration was 9 months. Observers were blinded to patient groupings and measurements.